Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma
Ferroptosis is a newly characterized form of iron-dependent non-apoptotic cell death, which is closely associated with cancer progression. However, the functions and mechanisms in regulation of escaping from ferroptosis during hepatocellular carcinoma (HCC) progression remain unknown. In this study,...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592294.2023.2192438 |
| _version_ | 1797678816831733760 |
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| author | Hang Zhai Sisi Zhong Runxin Wu Zhaohong Mo Shiyang Zheng Jinhua Xue Hongyu Meng Maosheng Liu Xianyu Chen Guangquan Zhang Xiyan Zheng Fei Du Ruixi Li Boxuan Zhou |
| author_facet | Hang Zhai Sisi Zhong Runxin Wu Zhaohong Mo Shiyang Zheng Jinhua Xue Hongyu Meng Maosheng Liu Xianyu Chen Guangquan Zhang Xiyan Zheng Fei Du Ruixi Li Boxuan Zhou |
| author_sort | Hang Zhai |
| collection | DOAJ |
| description | Ferroptosis is a newly characterized form of iron-dependent non-apoptotic cell death, which is closely associated with cancer progression. However, the functions and mechanisms in regulation of escaping from ferroptosis during hepatocellular carcinoma (HCC) progression remain unknown. In this study, we reported that the RNA binding motif single stranded interacting protein 1 (RBMS1) participated in HCC development，and functioned as a regulator of ferroptosis. Clinically, the downregulation of RBMS1 occurred in HCC tissues, and low RBMS1 expression was associated with worse HCC patients survival. Mechanistically, RBMS1 overexpression inhibited HCC cell growth by attenuating the expression of glutathione peroxidase 4 (GPX4)and further facilitated ferroptosis in vitro and in vivo. More importantly, a novel circIDE (hsa_circ_0000251) was identified to elevate RBMS1 expression via sponging miR-19b-3p in HCC cells. Collectively, our findings established circIDE/miR-19b-3p/RBMS1 axis as a regulator of ferroptosis, which could be a promising therapeutic target and prognostic factor. |
| first_indexed | 2024-03-11T23:05:26Z |
| format | Article |
| id | doaj.art-5b4b6bcfd6724c0abf96217f2db53342 |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T23:05:26Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-5b4b6bcfd6724c0abf96217f2db533422023-09-21T13:23:13ZengTaylor & Francis GroupEpigenetics1559-22941559-23082023-12-0118110.1080/15592294.2023.21924382192438Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinomaHang Zhai0Sisi Zhong1Runxin Wu2Zhaohong Mo3Shiyang Zheng4Jinhua Xue5Hongyu Meng6Maosheng Liu7Xianyu Chen8Guangquan Zhang9Xiyan Zheng10Fei Du11Ruixi Li12Boxuan Zhou13The First Affiliated Hospital of Gannan Medical UniversityThe First Affiliated Hospital of Gannan Medical UniversitySun Yat-sen UniversitySun Yat-sen UniversityCancer Center of Guangzhou Medical Universitythe School of Basic Medical Sciences of Gannan Medical UniversitySun Yat-sen Universitythe First Affiliated Hospital of Gannan Medical UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversitySun Yat-sen UniversityFerroptosis is a newly characterized form of iron-dependent non-apoptotic cell death, which is closely associated with cancer progression. However, the functions and mechanisms in regulation of escaping from ferroptosis during hepatocellular carcinoma (HCC) progression remain unknown. In this study, we reported that the RNA binding motif single stranded interacting protein 1 (RBMS1) participated in HCC development，and functioned as a regulator of ferroptosis. Clinically, the downregulation of RBMS1 occurred in HCC tissues, and low RBMS1 expression was associated with worse HCC patients survival. Mechanistically, RBMS1 overexpression inhibited HCC cell growth by attenuating the expression of glutathione peroxidase 4 (GPX4)and further facilitated ferroptosis in vitro and in vivo. More importantly, a novel circIDE (hsa_circ_0000251) was identified to elevate RBMS1 expression via sponging miR-19b-3p in HCC cells. Collectively, our findings established circIDE/miR-19b-3p/RBMS1 axis as a regulator of ferroptosis, which could be a promising therapeutic target and prognostic factor.http://dx.doi.org/10.1080/15592294.2023.2192438circrnaferroptosisrna binding protein |
| spellingShingle | Hang Zhai Sisi Zhong Runxin Wu Zhaohong Mo Shiyang Zheng Jinhua Xue Hongyu Meng Maosheng Liu Xianyu Chen Guangquan Zhang Xiyan Zheng Fei Du Ruixi Li Boxuan Zhou Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma Epigenetics circrna ferroptosis rna binding protein |
| title | Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma |
| title_full | Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma |
| title_fullStr | Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma |
| title_full_unstemmed | Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma |
| title_short | Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma |
| title_sort | suppressing circide mir 19b 3p rbms1 axis exhibits promoting tumour activity through upregulating gpx4 to diminish ferroptosis in hepatocellular carcinoma |
| topic | circrna ferroptosis rna binding protein |
| url | http://dx.doi.org/10.1080/15592294.2023.2192438 |
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