High Definition tDCS Effect on Postural Control in Healthy Individuals: Entropy Analysis of a Crossover Clinical Trial
Objective: Converging evidence supporting an effect of transcranial direct current stimulation (tDCS) on postural control and human verticality perception highlights this strategy as promising for post-stroke rehabilitation. We have previously demonstrated polarity-dependent effects of high-definiti...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/5/2703 |
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| author | Diandra B. Favoretto Eduardo Bergonzoni Diego Carvalho Nascimento Francisco Louzada Tenysson W. Lemos Rosangela A. Batistela Renato Moraes João P. Leite Brunna P. Rimoli Dylan J. Edwards Taiza G. S. Edwards |
| author_facet | Diandra B. Favoretto Eduardo Bergonzoni Diego Carvalho Nascimento Francisco Louzada Tenysson W. Lemos Rosangela A. Batistela Renato Moraes João P. Leite Brunna P. Rimoli Dylan J. Edwards Taiza G. S. Edwards |
| author_sort | Diandra B. Favoretto |
| collection | DOAJ |
| description | Objective: Converging evidence supporting an effect of transcranial direct current stimulation (tDCS) on postural control and human verticality perception highlights this strategy as promising for post-stroke rehabilitation. We have previously demonstrated polarity-dependent effects of high-definition tDCS (HD-tDCS) on weight-bearing asymmetry. However, there is no investigation regarding the time-course of effects on postural control induced by HD-tDCS protocols. Thus, we performed a nonlinear time series analysis focusing on the entropy of the ground reaction force as a secondary investigation of our randomized, double-blind, placebo-controlled, crossover clinical trial. Materials and Methods: Twenty healthy right-handed young adults received the following conditions (random order, separate days); anode center HD-tDCS, cathode center HD-tDCS or sham HD-tDCS at 1, 2, and 3 mA over the right temporo-parietal junction (TPJ). Using summarized time series of transfer entropy, we evaluated the exchanging information (causal direction) between both force plates and compared the dose-response across the healthy subjects with a Generalized Linear Hierarchical/Mixed Model (GLMM). Results: We found significant variation during the dynamic information flow (<i>p</i> < 0.001) among the dominant bodyside (and across time). A greater force transfer entropy was observed from the right to the left side during the cathode-center HD-tDCS up to 2 mA, with a causal relationship in the information flow (equilibrium force transfer) from right to left that decreased over time. Conclusions: HD-tDCS intervention induced a dynamic influence over time on postural control entropy. Right hemisphere TPJ stimulation using cathode-center HD-tDCS can induce an asymmetry of body weight distribution towards the ipsilateral side of stimulation. These results support the clinical potential of HD-tDCS for post-stroke rehabilitation. |
| first_indexed | 2024-03-09T20:46:37Z |
| format | Article |
| id | doaj.art-5b4c1beba2fd49ac98a9b3d7c0690f27 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T20:46:37Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-5b4c1beba2fd49ac98a9b3d7c0690f272023-11-23T22:45:01ZengMDPI AGApplied Sciences2076-34172022-03-01125270310.3390/app12052703High Definition tDCS Effect on Postural Control in Healthy Individuals: Entropy Analysis of a Crossover Clinical TrialDiandra B. Favoretto0Eduardo Bergonzoni1Diego Carvalho Nascimento2Francisco Louzada3Tenysson W. Lemos4Rosangela A. Batistela5Renato Moraes6João P. Leite7Brunna P. Rimoli8Dylan J. Edwards9Taiza G. S. Edwards10Department of Neuroscience and Behavior Sciences, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14015-010, BrazilDepartment of Neuroscience and Behavior Sciences, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14015-010, BrazilDepartamento de Matemática, Facultad de Ingeniería, Universidad de Atacama, Copiapó 1530000, ChileInstitute of Mathematical Science and Computing, University of Sao Paulo, Sao Carlos 13566-590, BrazilSchool of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040-907, BrazilSchool of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040-907, BrazilSchool of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040-907, BrazilDepartment of Neuroscience and Behavior Sciences, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14015-010, BrazilDepartment of Neuroscience and Behavior Sciences, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14015-010, BrazilMoss Rehabilitation Research Institute, Elkins Park, PA 19027, USADepartment of Neuroscience and Behavior Sciences, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14015-010, BrazilObjective: Converging evidence supporting an effect of transcranial direct current stimulation (tDCS) on postural control and human verticality perception highlights this strategy as promising for post-stroke rehabilitation. We have previously demonstrated polarity-dependent effects of high-definition tDCS (HD-tDCS) on weight-bearing asymmetry. However, there is no investigation regarding the time-course of effects on postural control induced by HD-tDCS protocols. Thus, we performed a nonlinear time series analysis focusing on the entropy of the ground reaction force as a secondary investigation of our randomized, double-blind, placebo-controlled, crossover clinical trial. Materials and Methods: Twenty healthy right-handed young adults received the following conditions (random order, separate days); anode center HD-tDCS, cathode center HD-tDCS or sham HD-tDCS at 1, 2, and 3 mA over the right temporo-parietal junction (TPJ). Using summarized time series of transfer entropy, we evaluated the exchanging information (causal direction) between both force plates and compared the dose-response across the healthy subjects with a Generalized Linear Hierarchical/Mixed Model (GLMM). Results: We found significant variation during the dynamic information flow (<i>p</i> < 0.001) among the dominant bodyside (and across time). A greater force transfer entropy was observed from the right to the left side during the cathode-center HD-tDCS up to 2 mA, with a causal relationship in the information flow (equilibrium force transfer) from right to left that decreased over time. Conclusions: HD-tDCS intervention induced a dynamic influence over time on postural control entropy. Right hemisphere TPJ stimulation using cathode-center HD-tDCS can induce an asymmetry of body weight distribution towards the ipsilateral side of stimulation. These results support the clinical potential of HD-tDCS for post-stroke rehabilitation.https://www.mdpi.com/2076-3417/12/5/2703high-definition transcranial direct current stimulationpostural controlentropynonlinear time series |
| spellingShingle | Diandra B. Favoretto Eduardo Bergonzoni Diego Carvalho Nascimento Francisco Louzada Tenysson W. Lemos Rosangela A. Batistela Renato Moraes João P. Leite Brunna P. Rimoli Dylan J. Edwards Taiza G. S. Edwards High Definition tDCS Effect on Postural Control in Healthy Individuals: Entropy Analysis of a Crossover Clinical Trial Applied Sciences high-definition transcranial direct current stimulation postural control entropy nonlinear time series |
| title | High Definition tDCS Effect on Postural Control in Healthy Individuals: Entropy Analysis of a Crossover Clinical Trial |
| title_full | High Definition tDCS Effect on Postural Control in Healthy Individuals: Entropy Analysis of a Crossover Clinical Trial |
| title_fullStr | High Definition tDCS Effect on Postural Control in Healthy Individuals: Entropy Analysis of a Crossover Clinical Trial |
| title_full_unstemmed | High Definition tDCS Effect on Postural Control in Healthy Individuals: Entropy Analysis of a Crossover Clinical Trial |
| title_short | High Definition tDCS Effect on Postural Control in Healthy Individuals: Entropy Analysis of a Crossover Clinical Trial |
| title_sort | high definition tdcs effect on postural control in healthy individuals entropy analysis of a crossover clinical trial |
| topic | high-definition transcranial direct current stimulation postural control entropy nonlinear time series |
| url | https://www.mdpi.com/2076-3417/12/5/2703 |
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