Etiological relationship between lipid metabolism and endometrial carcinoma
Abstract Endometrial carcinoma (EC) has become one of the most common gynecological malignant neoplasms in developed countries worldwide. Studies have shown that this may be closely related to the abnormal metabolism of blood lipids, which was the most significant metabolic change in the human body...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
|
| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-023-01868-2 |
| _version_ | 1797451684461412352 |
|---|---|
| author | Wenzhe Li Yi Xu Xinling Zeng Jie Tan Ya Wang Hongyan Wu Maokun Li Cunjian Yi |
| author_facet | Wenzhe Li Yi Xu Xinling Zeng Jie Tan Ya Wang Hongyan Wu Maokun Li Cunjian Yi |
| author_sort | Wenzhe Li |
| collection | DOAJ |
| description | Abstract Endometrial carcinoma (EC) has become one of the most common gynecological malignant neoplasms in developed countries worldwide. Studies have shown that this may be closely related to the abnormal metabolism of blood lipids, which was the most significant metabolic change in the human body in this cancer. In this review, we focus on the correlation between lipid metabolism and EC and discuss the evidence that abnormal lipid metabolism promotes an increase in EC growth and metabolism, as well as the regulatory mechanism and related signaling pathways involved in this relationship. In addition, we also discussed the research progress of targeted therapies and drug treatments for EC that act on lipid metabolism, and statins are expected to become adjuvant drugs for EC in the future. This review will provide a systematic view for a better understanding of the etiological relationship between lipid metabolism and EC and further open up new therapeutic possibilities and effective treatments for EC by targeting lipid metabolism. |
| first_indexed | 2024-03-09T14:57:04Z |
| format | Article |
| id | doaj.art-5b4daea2a2254aea9513e9c4869e4a5f |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-03-09T14:57:04Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-5b4daea2a2254aea9513e9c4869e4a5f2023-11-26T14:05:45ZengBMCLipids in Health and Disease1476-511X2023-08-0122111110.1186/s12944-023-01868-2Etiological relationship between lipid metabolism and endometrial carcinomaWenzhe Li0Yi Xu1Xinling Zeng2Jie Tan3Ya Wang4Hongyan Wu5Maokun Li6Cunjian Yi7Department of Endocrinology, The First Affiliated Hospital of Yangtze UniversityDepartment of Endocrinology, The First Affiliated Hospital of Yangtze UniversityDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Yangtze UniversityDepartment of Hematology, The First Affiliated Hospital of Yangtze UniversityDepartment of Endocrinology, The First Affiliated Hospital of Yangtze UniversityDepartment of Endocrinology, The First Affiliated Hospital of Yangtze UniversityDepartment of Hubei Provincial Clinical Research Center for Personalized Diagnosis and Treatment of Cancer, The First Affiliated Hospital of Yangtze UniversityDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Yangtze UniversityAbstract Endometrial carcinoma (EC) has become one of the most common gynecological malignant neoplasms in developed countries worldwide. Studies have shown that this may be closely related to the abnormal metabolism of blood lipids, which was the most significant metabolic change in the human body in this cancer. In this review, we focus on the correlation between lipid metabolism and EC and discuss the evidence that abnormal lipid metabolism promotes an increase in EC growth and metabolism, as well as the regulatory mechanism and related signaling pathways involved in this relationship. In addition, we also discussed the research progress of targeted therapies and drug treatments for EC that act on lipid metabolism, and statins are expected to become adjuvant drugs for EC in the future. This review will provide a systematic view for a better understanding of the etiological relationship between lipid metabolism and EC and further open up new therapeutic possibilities and effective treatments for EC by targeting lipid metabolism.https://doi.org/10.1186/s12944-023-01868-2Lipid metabolismEndometrial carcinomaEtiological relationshipStatinsBiological mechanisms |
| spellingShingle | Wenzhe Li Yi Xu Xinling Zeng Jie Tan Ya Wang Hongyan Wu Maokun Li Cunjian Yi Etiological relationship between lipid metabolism and endometrial carcinoma Lipids in Health and Disease Lipid metabolism Endometrial carcinoma Etiological relationship Statins Biological mechanisms |
| title | Etiological relationship between lipid metabolism and endometrial carcinoma |
| title_full | Etiological relationship between lipid metabolism and endometrial carcinoma |
| title_fullStr | Etiological relationship between lipid metabolism and endometrial carcinoma |
| title_full_unstemmed | Etiological relationship between lipid metabolism and endometrial carcinoma |
| title_short | Etiological relationship between lipid metabolism and endometrial carcinoma |
| title_sort | etiological relationship between lipid metabolism and endometrial carcinoma |
| topic | Lipid metabolism Endometrial carcinoma Etiological relationship Statins Biological mechanisms |
| url | https://doi.org/10.1186/s12944-023-01868-2 |
| work_keys_str_mv | AT wenzheli etiologicalrelationshipbetweenlipidmetabolismandendometrialcarcinoma AT yixu etiologicalrelationshipbetweenlipidmetabolismandendometrialcarcinoma AT xinlingzeng etiologicalrelationshipbetweenlipidmetabolismandendometrialcarcinoma AT jietan etiologicalrelationshipbetweenlipidmetabolismandendometrialcarcinoma AT yawang etiologicalrelationshipbetweenlipidmetabolismandendometrialcarcinoma AT hongyanwu etiologicalrelationshipbetweenlipidmetabolismandendometrialcarcinoma AT maokunli etiologicalrelationshipbetweenlipidmetabolismandendometrialcarcinoma AT cunjianyi etiologicalrelationshipbetweenlipidmetabolismandendometrialcarcinoma |