Phenethylisothiocyanate Potentiates Platinum Therapy by Reversing Cisplatin Resistance in Cervical Cancer

Phenethylisothiocyanate Potentiates Platinum Therapy by Reversing Cisplatin Resistance in Cervical Cancer

Acquired cisplatin resistance in cervical cancer therapy is principally caused by reduction in intracellular drug accumulation, which is exerted by hyperactivation of the oncogenic PI3K/Akt signaling axis and overexpression of cisplatin-exporter MRP2 along with prosurvival effectors NF-κB and IAPs i...

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Bibliographic Details
Main Authors: Elizabeth Mahapatra, Debomita Sengupta, Ravindra Kumar, Budheswar Dehury, Salini Das, Madhumita Roy, Sutapa Mukherjee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
PEITC
chemosensitization
cisplatin resistance
MRP2
PI3K/AKT
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.803114/full

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