Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men

The aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the im...

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Main Authors:	Marie-Thérèse Berthier, Alain Houde, Mélanie Côté, Ann-Marie Paradis, Pascale Mauriège, Jean Bergeron, Daniel Gaudet, Jean-Pierre Després, Marie-Claude Vohl
Format:	Article
Language:	English
Published:	Elsevier 2005-02-01
Series:	Journal of Lipid Research
Subjects:	Apm1 dyslipidemia insulin resistance
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520340566

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author	Marie-Thérèse Berthier Alain Houde Mélanie Côté Ann-Marie Paradis Pascale Mauriège Jean Bergeron Daniel Gaudet Jean-Pierre Després Marie-Claude Vohl
author_facet	Marie-Thérèse Berthier Alain Houde Mélanie Côté Ann-Marie Paradis Pascale Mauriège Jean Bergeron Daniel Gaudet Jean-Pierre Després Marie-Claude Vohl
author_sort	Marie-Thérèse Berthier
collection	DOAJ
description	The aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the impact of these polymorphisms on metabolic risk variables. Molecular screening of the Apm1 gene was achieved, and a sample of 270 unrelated men recruited from the greater Quebec City area and selected to cover a wide range of body fatness values was genotyped. Sequencing of the Apm1 gene revealed two previously reported polymorphisms (c.45T>G and c.276G>T) as well as two newly identified genetic variations (−13752delT and −13702G>C). Carriers of the c.276T allele had higher LDL-cholesterol and lower HDL-triglyceride concentrations than did 276G/G homozygotes (P = 0.02 and P = 0.01, respectively). Carriers of the c.45G allele exhibited higher plasma adiponectin concentrations than did 45T/T homozygotes (P = 0.04). After dividing each genotype group into subgroups for visceral AT, homozygotes for the normal allele at position −13752delT, carriers of the c.45G allele, and carriers of the c.276T allele had similar total apolipoprotein B (apoB) concentrations, whether they were viscerally obese or not.These results suggest that some Apm1 gene polymorphisms influence plasma adiponectin concentrations and lipoprotein/lipid levels. In addition, the impact of these polymorphisms is modulated by the presence of visceral obesity.
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format	Article
id	doaj.art-5b4eeecb8c8e4d8ba00fad34fdc3cfee
institution	Directory Open Access Journal
issn	0022-2275
language	English
last_indexed	2024-12-17T08:37:48Z
publishDate	2005-02-01
publisher	Elsevier
record_format	Article
series	Journal of Lipid Research
spelling	doaj.art-5b4eeecb8c8e4d8ba00fad34fdc3cfee2022-12-21T21:56:26ZengElsevierJournal of Lipid Research0022-22752005-02-01462237244Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese menMarie-Thérèse Berthier0Alain Houde1Mélanie Côté2Ann-Marie Paradis3Pascale Mauriège4Jean Bergeron5Daniel Gaudet6Jean-Pierre Després7Marie-Claude Vohl8Lipid Research Center, CHUL Research Center, Sainte-Foy, Québec, Canada; Food Science and Nutrition Department, Laval University, Québec, Canada; Québec Heart Institute, Sainte-Foy, Québec, Canada; Department of Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada; Dyslipidemia, Diabetes, and Atherosclerosis Group, Complexe Hospitalier de la Sagamie, Saguenay, Quebec, CanadaLipid Research Center, CHUL Research Center, Sainte-Foy, Québec, Canada; Food Science and Nutrition Department, Laval University, Québec, Canada; Québec Heart Institute, Sainte-Foy, Québec, Canada; Department of Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada; Dyslipidemia, Diabetes, and Atherosclerosis Group, Complexe Hospitalier de la Sagamie, Saguenay, Quebec, CanadaLipid Research Center, CHUL Research Center, Sainte-Foy, Québec, Canada; Food Science and Nutrition Department, Laval University, Québec, Canada; Québec Heart Institute, Sainte-Foy, Québec, Canada; Department of Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada; Dyslipidemia, Diabetes, and Atherosclerosis Group, Complexe Hospitalier de la Sagamie, Saguenay, Quebec, CanadaLipid Research Center, CHUL Research Center, Sainte-Foy, Québec, Canada; Food Science and Nutrition Department, Laval University, Québec, Canada; Québec Heart Institute, Sainte-Foy, Québec, Canada; Department of Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada; Dyslipidemia, Diabetes, and Atherosclerosis Group, Complexe Hospitalier de la Sagamie, Saguenay, Quebec, CanadaLipid Research Center, CHUL Research Center, Sainte-Foy, Québec, Canada; Food Science and Nutrition Department, Laval University, Québec, Canada; Québec Heart Institute, Sainte-Foy, Québec, Canada; Department of Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada; Dyslipidemia, Diabetes, and Atherosclerosis Group, Complexe Hospitalier de la Sagamie, Saguenay, Quebec, CanadaLipid Research Center, CHUL Research Center, Sainte-Foy, Québec, Canada; Food Science and Nutrition Department, Laval University, Québec, Canada; Québec Heart Institute, Sainte-Foy, Québec, Canada; Department of Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada; Dyslipidemia, Diabetes, and Atherosclerosis Group, Complexe Hospitalier de la Sagamie, Saguenay, Quebec, CanadaLipid Research Center, CHUL Research Center, Sainte-Foy, Québec, Canada; Food Science and Nutrition Department, Laval University, Québec, Canada; Québec Heart Institute, Sainte-Foy, Québec, Canada; Department of Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada; Dyslipidemia, Diabetes, and Atherosclerosis Group, Complexe Hospitalier de la Sagamie, Saguenay, Quebec, CanadaLipid Research Center, CHUL Research Center, Sainte-Foy, Québec, Canada; Food Science and Nutrition Department, Laval University, Québec, Canada; Québec Heart Institute, Sainte-Foy, Québec, Canada; Department of Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada; Dyslipidemia, Diabetes, and Atherosclerosis Group, Complexe Hospitalier de la Sagamie, Saguenay, Quebec, CanadaLipid Research Center, CHUL Research Center, Sainte-Foy, Québec, Canada; Food Science and Nutrition Department, Laval University, Québec, Canada; Québec Heart Institute, Sainte-Foy, Québec, Canada; Department of Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada; Dyslipidemia, Diabetes, and Atherosclerosis Group, Complexe Hospitalier de la Sagamie, Saguenay, Quebec, CanadaThe aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the impact of these polymorphisms on metabolic risk variables. Molecular screening of the Apm1 gene was achieved, and a sample of 270 unrelated men recruited from the greater Quebec City area and selected to cover a wide range of body fatness values was genotyped. Sequencing of the Apm1 gene revealed two previously reported polymorphisms (c.45T>G and c.276G>T) as well as two newly identified genetic variations (−13752delT and −13702G>C). Carriers of the c.276T allele had higher LDL-cholesterol and lower HDL-triglyceride concentrations than did 276G/G homozygotes (P = 0.02 and P = 0.01, respectively). Carriers of the c.45G allele exhibited higher plasma adiponectin concentrations than did 45T/T homozygotes (P = 0.04). After dividing each genotype group into subgroups for visceral AT, homozygotes for the normal allele at position −13752delT, carriers of the c.45G allele, and carriers of the c.276T allele had similar total apolipoprotein B (apoB) concentrations, whether they were viscerally obese or not.These results suggest that some Apm1 gene polymorphisms influence plasma adiponectin concentrations and lipoprotein/lipid levels. In addition, the impact of these polymorphisms is modulated by the presence of visceral obesity.http://www.sciencedirect.com/science/article/pii/S0022227520340566Apm1dyslipidemiainsulin resistance
spellingShingle	Marie-Thérèse Berthier Alain Houde Mélanie Côté Ann-Marie Paradis Pascale Mauriège Jean Bergeron Daniel Gaudet Jean-Pierre Després Marie-Claude Vohl Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men Journal of Lipid Research Apm1 dyslipidemia insulin resistance
title	Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
title_full	Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
title_fullStr	Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
title_full_unstemmed	Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
title_short	Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
title_sort	impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
topic	Apm1 dyslipidemia insulin resistance
url	http://www.sciencedirect.com/science/article/pii/S0022227520340566
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Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men

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