Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities
The Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations and its resistance to currently available therapie...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836319/?tool=EBI |
| _version_ | 1828063266471936000 |
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| author | Rahul Kumar Öznur Aktay-Cetin Vaughn Craddock Daniel Morales-Cano Djuro Kosanovic Angel Cogolludo Francisco Perez-Vizcaino Sergey Avdeev Ashok Kumar Anil Kumar Ram Stuti Agarwal Ananya Chakraborty Rajkumar Savai Vinicio de Jesus Perez Brian B. Graham Ghazwan Butrous Navneet K. Dhillon |
| author_facet | Rahul Kumar Öznur Aktay-Cetin Vaughn Craddock Daniel Morales-Cano Djuro Kosanovic Angel Cogolludo Francisco Perez-Vizcaino Sergey Avdeev Ashok Kumar Anil Kumar Ram Stuti Agarwal Ananya Chakraborty Rajkumar Savai Vinicio de Jesus Perez Brian B. Graham Ghazwan Butrous Navneet K. Dhillon |
| author_sort | Rahul Kumar |
| collection | DOAJ |
| description | The Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations and its resistance to currently available therapies. COVID-19, although targeting primarily the respiratory system, is also now well established that later affects every organ in the body. Most importantly, despite the available therapy and vaccine-elicited protection, the long-term consequences of viral infection in breakthrough and asymptomatic individuals are areas of concern. In the past two years, investigators accumulated evidence on how the virus triggers our immune system and the molecular signals involved in the cross-talk between immune cells and structural cells in the pulmonary vasculature to drive pathological lung complications such as endothelial dysfunction and thrombosis. In the review, we emphasize recent updates on the pathophysiological inflammatory and immune responses associated with SARS-CoV-2 infection and their potential long-term consequences that may consequently lead to the development of pulmonary vascular diseases. |
| first_indexed | 2024-04-10T22:40:29Z |
| format | Article |
| id | doaj.art-5b4f2adb011247f9a651b4d2891c55bf |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-04-10T22:40:29Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-5b4f2adb011247f9a651b4d2891c55bf2023-01-16T05:31:07ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742023-01-01191Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbiditiesRahul KumarÖznur Aktay-CetinVaughn CraddockDaniel Morales-CanoDjuro KosanovicAngel CogolludoFrancisco Perez-VizcainoSergey AvdeevAshok KumarAnil Kumar RamStuti AgarwalAnanya ChakrabortyRajkumar SavaiVinicio de Jesus PerezBrian B. GrahamGhazwan ButrousNavneet K. DhillonThe Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations and its resistance to currently available therapies. COVID-19, although targeting primarily the respiratory system, is also now well established that later affects every organ in the body. Most importantly, despite the available therapy and vaccine-elicited protection, the long-term consequences of viral infection in breakthrough and asymptomatic individuals are areas of concern. In the past two years, investigators accumulated evidence on how the virus triggers our immune system and the molecular signals involved in the cross-talk between immune cells and structural cells in the pulmonary vasculature to drive pathological lung complications such as endothelial dysfunction and thrombosis. In the review, we emphasize recent updates on the pathophysiological inflammatory and immune responses associated with SARS-CoV-2 infection and their potential long-term consequences that may consequently lead to the development of pulmonary vascular diseases.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836319/?tool=EBI |
| spellingShingle | Rahul Kumar Öznur Aktay-Cetin Vaughn Craddock Daniel Morales-Cano Djuro Kosanovic Angel Cogolludo Francisco Perez-Vizcaino Sergey Avdeev Ashok Kumar Anil Kumar Ram Stuti Agarwal Ananya Chakraborty Rajkumar Savai Vinicio de Jesus Perez Brian B. Graham Ghazwan Butrous Navneet K. Dhillon Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities PLoS Pathogens |
| title | Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities |
| title_full | Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities |
| title_fullStr | Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities |
| title_full_unstemmed | Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities |
| title_short | Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities |
| title_sort | potential long term effects of sars cov 2 infection on the pulmonary vasculature multilayered cross talks in the setting of coinfections and comorbidities |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836319/?tool=EBI |
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