Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders
Most neurodegenerative disorders have complex and still unresolved pathology characterized by progressive neuronal damage and death. Astrocytes, the most-abundant non-neuronal cell population in the central nervous system, play a vital role in these processes. They are involved in various functions...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/3/344 |
| _version_ | 1797472685730562048 |
|---|---|
| author | Mandeep Kumar Nhung Thi Phuong Nguyen Marco Milanese Giambattista Bonanno |
| author_facet | Mandeep Kumar Nhung Thi Phuong Nguyen Marco Milanese Giambattista Bonanno |
| author_sort | Mandeep Kumar |
| collection | DOAJ |
| description | Most neurodegenerative disorders have complex and still unresolved pathology characterized by progressive neuronal damage and death. Astrocytes, the most-abundant non-neuronal cell population in the central nervous system, play a vital role in these processes. They are involved in various functions in the brain, such as the regulation of synapse formation, neuroinflammation, and lactate and glutamate levels. The development of human-induced pluripotent stem cells (iPSCs) reformed the research in neurodegenerative disorders allowing for the generation of disease-relevant neuronal and non-neuronal cell types that can help in disease modeling, drug screening, and, possibly, cell transplantation strategies. In the last 14 years, the differentiation of human iPSCs into astrocytes allowed for the opportunity to explore the contribution of astrocytes to neurodegenerative diseases. This review discusses the development protocols and applications of human iPSC-derived astrocytes in the most common neurodegenerative conditions. |
| first_indexed | 2024-03-09T20:04:44Z |
| format | Article |
| id | doaj.art-5b50a7f789904c5da2509093996d4c88 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:04:44Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-5b50a7f789904c5da2509093996d4c882023-11-24T00:34:39ZengMDPI AGBiomolecules2218-273X2022-02-0112334410.3390/biom12030344Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative DisordersMandeep Kumar0Nhung Thi Phuong Nguyen1Marco Milanese2Giambattista Bonanno3Department of Pharmacy, Unit of Pharmacology and Toxicology, University of Genoa, 16148 Genoa, ItalyDepartment of Pharmacy, Unit of Pharmacology and Toxicology, University of Genoa, 16148 Genoa, ItalyDepartment of Pharmacy, Unit of Pharmacology and Toxicology, University of Genoa, 16148 Genoa, ItalyDepartment of Pharmacy, Unit of Pharmacology and Toxicology, University of Genoa, 16148 Genoa, ItalyMost neurodegenerative disorders have complex and still unresolved pathology characterized by progressive neuronal damage and death. Astrocytes, the most-abundant non-neuronal cell population in the central nervous system, play a vital role in these processes. They are involved in various functions in the brain, such as the regulation of synapse formation, neuroinflammation, and lactate and glutamate levels. The development of human-induced pluripotent stem cells (iPSCs) reformed the research in neurodegenerative disorders allowing for the generation of disease-relevant neuronal and non-neuronal cell types that can help in disease modeling, drug screening, and, possibly, cell transplantation strategies. In the last 14 years, the differentiation of human iPSCs into astrocytes allowed for the opportunity to explore the contribution of astrocytes to neurodegenerative diseases. This review discusses the development protocols and applications of human iPSC-derived astrocytes in the most common neurodegenerative conditions.https://www.mdpi.com/2218-273X/12/3/344human-induced pluripotent stem cellsneurodegenerative diseaseiPSC-derived astrocytesdisease modeling |
| spellingShingle | Mandeep Kumar Nhung Thi Phuong Nguyen Marco Milanese Giambattista Bonanno Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders Biomolecules human-induced pluripotent stem cells neurodegenerative disease iPSC-derived astrocytes disease modeling |
| title | Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders |
| title_full | Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders |
| title_fullStr | Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders |
| title_full_unstemmed | Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders |
| title_short | Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders |
| title_sort | insights into human induced pluripotent stem cell derived astrocytes in neurodegenerative disorders |
| topic | human-induced pluripotent stem cells neurodegenerative disease iPSC-derived astrocytes disease modeling |
| url | https://www.mdpi.com/2218-273X/12/3/344 |
| work_keys_str_mv | AT mandeepkumar insightsintohumaninducedpluripotentstemcellderivedastrocytesinneurodegenerativedisorders AT nhungthiphuongnguyen insightsintohumaninducedpluripotentstemcellderivedastrocytesinneurodegenerativedisorders AT marcomilanese insightsintohumaninducedpluripotentstemcellderivedastrocytesinneurodegenerativedisorders AT giambattistabonanno insightsintohumaninducedpluripotentstemcellderivedastrocytesinneurodegenerativedisorders |