Ultrasound single-phase CBE imaging for monitoring radiofrequency ablation of the liver tumor: A preliminary clinical validation
Radiofrequency ablation (RFA) is an alternative treatment for early-stage hepatocellular carcinoma (HCC). The production of gas bubbles by RFA indicates threshold temperature of tissue necrosis and results in changes in backscattered energy (CBE) when ultrasound monitors RFA. In this study, ultrasou...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.894246/full |
| _version_ | 1818511820626853888 |
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| author | Chiao-Yin Wang Zhuhuang Zhou Yu-Hsuan Chang Ming-Chih Ho Ming-Chih Ho Ming-Chih Ho Chiu-Min Lu Chih-Horng Wu Chih-Horng Wu Po-Hsiang Tsui Po-Hsiang Tsui Po-Hsiang Tsui |
| author_facet | Chiao-Yin Wang Zhuhuang Zhou Yu-Hsuan Chang Ming-Chih Ho Ming-Chih Ho Ming-Chih Ho Chiu-Min Lu Chih-Horng Wu Chih-Horng Wu Po-Hsiang Tsui Po-Hsiang Tsui Po-Hsiang Tsui |
| author_sort | Chiao-Yin Wang |
| collection | DOAJ |
| description | Radiofrequency ablation (RFA) is an alternative treatment for early-stage hepatocellular carcinoma (HCC). The production of gas bubbles by RFA indicates threshold temperature of tissue necrosis and results in changes in backscattered energy (CBE) when ultrasound monitors RFA. In this study, ultrasound single-phase CBE imaging was used as a means of monitoring RFA of the liver tumor by analyzing the backscattering of ultrasound from gas bubbles in the liver. A total of 19 HCC patients were enrolled in the study. An ultrasound system was used during RFA to monitor the ablation process and acquire raw image data consisting of backscattered signals for single-phase CBE imaging. On the basis of single-phase CBE imaging, the area corresponding to the range of gas bubbles was compared with the tumor sizes and ablation zones estimated from computed tomography. During RFA, ultrasound single-phase CBE imaging enabled improved visualization of gas bubbles. Measured gas bubble areas by CBE were related to tumor size (the Spearman correlation coefficient rs = 0.86; p < 0.05); less dependent on the ablation zone. Approximately 95% of the data fell within the limits of agreement in Bland-Altman plots, and 58% of the data fell within the 95% CI. This study suggests that single-phase CBE imaging provides information about liver tumor size because of the abundant vessels in liver tumors that promote the generation of gas bubbles, which serve as natural contrast agents in RFAs to enhance ultrasound backscattering. Ultrasound single-phase CBE imaging may allow clinicians to determine if the required minimum RFA efficacy level is reached by assessing gas bubbles in the liver tumors. |
| first_indexed | 2024-12-10T23:38:14Z |
| format | Article |
| id | doaj.art-5b55b5531d2647eb802f47a202ac7879 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T23:38:14Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5b55b5531d2647eb802f47a202ac78792022-12-22T01:29:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.894246894246Ultrasound single-phase CBE imaging for monitoring radiofrequency ablation of the liver tumor: A preliminary clinical validationChiao-Yin Wang0Zhuhuang Zhou1Yu-Hsuan Chang2Ming-Chih Ho3Ming-Chih Ho4Ming-Chih Ho5Chiu-Min Lu6Chih-Horng Wu7Chih-Horng Wu8Po-Hsiang Tsui9Po-Hsiang Tsui10Po-Hsiang Tsui11Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing, ChinaDepartment of Medical Imaging, National Taiwan University Hospital, Taipei, TaiwanDepartments of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, TaiwanCenter for Functional Image and Interventional Image, National Taiwan University, Taipei, TaiwanDepartment of Surgery, National Taiwan University Hospital Hsin-Chu Biomedical Park Branch, Hsin-Chu, TaiwanDepartment of Medical Imaging, National Taiwan University Hospital, Taipei, TaiwanDepartment of Medical Imaging, National Taiwan University Hospital, Taipei, TaiwanDepartment of Radiology, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Pediatric Gastroenterology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, TaiwanDepartment of Biomedical Engineering, Chang Gung University, Taoyuan, TaiwanRadiofrequency ablation (RFA) is an alternative treatment for early-stage hepatocellular carcinoma (HCC). The production of gas bubbles by RFA indicates threshold temperature of tissue necrosis and results in changes in backscattered energy (CBE) when ultrasound monitors RFA. In this study, ultrasound single-phase CBE imaging was used as a means of monitoring RFA of the liver tumor by analyzing the backscattering of ultrasound from gas bubbles in the liver. A total of 19 HCC patients were enrolled in the study. An ultrasound system was used during RFA to monitor the ablation process and acquire raw image data consisting of backscattered signals for single-phase CBE imaging. On the basis of single-phase CBE imaging, the area corresponding to the range of gas bubbles was compared with the tumor sizes and ablation zones estimated from computed tomography. During RFA, ultrasound single-phase CBE imaging enabled improved visualization of gas bubbles. Measured gas bubble areas by CBE were related to tumor size (the Spearman correlation coefficient rs = 0.86; p < 0.05); less dependent on the ablation zone. Approximately 95% of the data fell within the limits of agreement in Bland-Altman plots, and 58% of the data fell within the 95% CI. This study suggests that single-phase CBE imaging provides information about liver tumor size because of the abundant vessels in liver tumors that promote the generation of gas bubbles, which serve as natural contrast agents in RFAs to enhance ultrasound backscattering. Ultrasound single-phase CBE imaging may allow clinicians to determine if the required minimum RFA efficacy level is reached by assessing gas bubbles in the liver tumors.https://www.frontiersin.org/articles/10.3389/fonc.2022.894246/fullultrasoundradiofrequency ablationCBE imagingliver tumorHCC (hepatic cellular carcinoma) |
| spellingShingle | Chiao-Yin Wang Zhuhuang Zhou Yu-Hsuan Chang Ming-Chih Ho Ming-Chih Ho Ming-Chih Ho Chiu-Min Lu Chih-Horng Wu Chih-Horng Wu Po-Hsiang Tsui Po-Hsiang Tsui Po-Hsiang Tsui Ultrasound single-phase CBE imaging for monitoring radiofrequency ablation of the liver tumor: A preliminary clinical validation Frontiers in Oncology ultrasound radiofrequency ablation CBE imaging liver tumor HCC (hepatic cellular carcinoma) |
| title | Ultrasound single-phase CBE imaging for monitoring radiofrequency ablation of the liver tumor: A preliminary clinical validation |
| title_full | Ultrasound single-phase CBE imaging for monitoring radiofrequency ablation of the liver tumor: A preliminary clinical validation |
| title_fullStr | Ultrasound single-phase CBE imaging for monitoring radiofrequency ablation of the liver tumor: A preliminary clinical validation |
| title_full_unstemmed | Ultrasound single-phase CBE imaging for monitoring radiofrequency ablation of the liver tumor: A preliminary clinical validation |
| title_short | Ultrasound single-phase CBE imaging for monitoring radiofrequency ablation of the liver tumor: A preliminary clinical validation |
| title_sort | ultrasound single phase cbe imaging for monitoring radiofrequency ablation of the liver tumor a preliminary clinical validation |
| topic | ultrasound radiofrequency ablation CBE imaging liver tumor HCC (hepatic cellular carcinoma) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.894246/full |
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