Food Inhibits the Oral Bioavailability of the Major Green Tea Antioxidant Epigallocatechin Gallate in Humans
The bioavailability of the most abundant and most active green tea antioxidant, epigallocatechin gallate (EGCG) remains uncertain. Therefore, the systemic absorption of EGCG was tested in healthy fasted humans. It was administered as capsules with water or with a light breakfast, or when incorporat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-05-01
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| Series: | Antioxidants |
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| Online Access: | http://www.mdpi.com/2076-3921/4/2/373 |
| _version_ | 1797712535876534272 |
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| author | Nenad Naumovski Barbara L. Blades Paul D. Roach |
| author_facet | Nenad Naumovski Barbara L. Blades Paul D. Roach |
| author_sort | Nenad Naumovski |
| collection | DOAJ |
| description | The bioavailability of the most abundant and most active green tea antioxidant, epigallocatechin gallate (EGCG) remains uncertain. Therefore, the systemic absorption of EGCG was tested in healthy fasted humans. It was administered as capsules with water or with a light breakfast, or when incorporated within a strawberry sorbet. The results for plasma EGCG clearly revealed that taking EGCG capsules without food was better; the AUC was 2.7 and 3.9 times higher than when EGCG capsules were taken with a light breakfast (p = 0.044) or with EGCG imbedded in the strawberry sorbet (p = 0.019), respectively. This pattern was also observed for Cmax and Cav. Therefore, ingesting food at the same time as EGCG, whether it was imbedded or not in food, substantially inhibited the absorption of the catechin. As with some types of medications that are affected by food, it appears that EGCG should be taken without food in order to maximise its systemic absorption. Therefore, based on these findings, ingesting EGCG with water on an empty stomach is the most appropriate method for the oral delivery of EGCG in clinical trials where EGCG is to be investigated as a potential bioactive nutraceutical in humans. |
| first_indexed | 2024-03-12T07:23:11Z |
| format | Article |
| id | doaj.art-5b55d9d501154768a4720687d92b406e |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T07:23:11Z |
| publishDate | 2015-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-5b55d9d501154768a4720687d92b406e2023-09-02T22:15:50ZengMDPI AGAntioxidants2076-39212015-05-014237339310.3390/antiox4020373antiox4020373Food Inhibits the Oral Bioavailability of the Major Green Tea Antioxidant Epigallocatechin Gallate in HumansNenad Naumovski0Barbara L. Blades1Paul D. Roach2School of Public Health and Nutrition, University of Canberra, Canberra 2601, ACT, AustraliaSchool of Environmental & Life Sciences, University of Newcastle, Ourimbah 2258, NSW, AustraliaSchool of Environmental & Life Sciences, University of Newcastle, Ourimbah 2258, NSW, AustraliaThe bioavailability of the most abundant and most active green tea antioxidant, epigallocatechin gallate (EGCG) remains uncertain. Therefore, the systemic absorption of EGCG was tested in healthy fasted humans. It was administered as capsules with water or with a light breakfast, or when incorporated within a strawberry sorbet. The results for plasma EGCG clearly revealed that taking EGCG capsules without food was better; the AUC was 2.7 and 3.9 times higher than when EGCG capsules were taken with a light breakfast (p = 0.044) or with EGCG imbedded in the strawberry sorbet (p = 0.019), respectively. This pattern was also observed for Cmax and Cav. Therefore, ingesting food at the same time as EGCG, whether it was imbedded or not in food, substantially inhibited the absorption of the catechin. As with some types of medications that are affected by food, it appears that EGCG should be taken without food in order to maximise its systemic absorption. Therefore, based on these findings, ingesting EGCG with water on an empty stomach is the most appropriate method for the oral delivery of EGCG in clinical trials where EGCG is to be investigated as a potential bioactive nutraceutical in humans.http://www.mdpi.com/2076-3921/4/2/373EGCGsystemic absorptiongreen tea catechinsfunctional foods |
| spellingShingle | Nenad Naumovski Barbara L. Blades Paul D. Roach Food Inhibits the Oral Bioavailability of the Major Green Tea Antioxidant Epigallocatechin Gallate in Humans Antioxidants EGCG systemic absorption green tea catechins functional foods |
| title | Food Inhibits the Oral Bioavailability of the Major Green Tea Antioxidant Epigallocatechin Gallate in Humans |
| title_full | Food Inhibits the Oral Bioavailability of the Major Green Tea Antioxidant Epigallocatechin Gallate in Humans |
| title_fullStr | Food Inhibits the Oral Bioavailability of the Major Green Tea Antioxidant Epigallocatechin Gallate in Humans |
| title_full_unstemmed | Food Inhibits the Oral Bioavailability of the Major Green Tea Antioxidant Epigallocatechin Gallate in Humans |
| title_short | Food Inhibits the Oral Bioavailability of the Major Green Tea Antioxidant Epigallocatechin Gallate in Humans |
| title_sort | food inhibits the oral bioavailability of the major green tea antioxidant epigallocatechin gallate in humans |
| topic | EGCG systemic absorption green tea catechins functional foods |
| url | http://www.mdpi.com/2076-3921/4/2/373 |
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