Wnt Signaling Inhibits High-Density Cell Sheet Culture Induced Mesenchymal Stromal Cell Aging by Targeting Cell Cycle Inhibitor p27

Wnt Signaling Inhibits High-Density Cell Sheet Culture Induced Mesenchymal Stromal Cell Aging by Targeting Cell Cycle Inhibitor p27

Mesenchymal stromal cell senescence and apoptosis have been identified as critical molecular hallmarks in aging. In this study, we used stromal cell sheet culture as an in vitro model to study the progressive changes of cellular senescence, apoptosis and underlying mechanism in Wnt3a treated cells....

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Bibliographic Details
Main Authors: Ying Xu, Ye Tian, Dongyi Tong, Hao Zhang, Zhengliang Luo, Xifu Shang, Yufeng Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
aging
cell sheet culture
senescence
apoptosis
stromal cell
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00946/full

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