Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling.
In order to model squamous cell carcinoma development in vivo, researchers have long preferred hairless mouse models such as SKH-1 mice that have traditionally been classified as 'wild-type' mice irrespective of the genetic factors underlying their hairless phenotype. The work presented he...
Main Authors: | Hyunmi Kim, Alexandre Casta, Xiuwei Tang, Courtney T Luke, Arianna L Kim, David R Bickers, Mohammad Athar, Angela M Christiano |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3382590?pdf=render |
Similar Items
-
NF-kappaB in Lung Tumorigenesis
by: William N. Rom, et al.
Published: (2011-12-01) -
NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
by: Smith, C, et al.
Published: (2001) -
Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
by: Andreakos, E, et al.
Published: (2006) -
Visualization of lymphatic vessels through NF-kappaB activity.
by: Saban, MR, et al.
Published: (2004) -
NF-kappaB Signaling in Chronic Inflammatory Airway Disease
by: Michael Schuliga
Published: (2015-06-01)