Interactions between genes and environmental factors in asthma and atopy: new developments
<p>Abstract</p> <p>Asthma and associated phenotypes are complex traits most probably caused by an interaction of multiple disease susceptibility genes and environmental factors. Major achievements have occurred in identifying chromosomal regions and polymorphisms in candidate genes...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2001-10-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1186/rr179 |
| _version_ | 1818211449386827776 |
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| author | Sengler Claudia Lau Susanne Wahn Ulrich Nickel Renate |
| author_facet | Sengler Claudia Lau Susanne Wahn Ulrich Nickel Renate |
| author_sort | Sengler Claudia |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Asthma and associated phenotypes are complex traits most probably caused by an interaction of multiple disease susceptibility genes and environmental factors. Major achievements have occurred in identifying chromosomal regions and polymorphisms in candidate genes linked to or associated with asthma, atopic dermatitis, IgE levels and response to asthma therapy. The aims of this review are to explain the methodology of genetic studies of multifactorial diseases, to summarize chromosomal regions and polymorphisms in candidate genes linked to or associated with asthma and associated traits, to list genetic alterations that may alter response to asthma therapy, and to outline genetic factors that may render individuals more susceptible to asthma and atopy due to environmental changes.</p> |
| first_indexed | 2024-12-12T05:32:41Z |
| format | Article |
| id | doaj.art-5b5819b0d7d64e7f94190dc61706e45d |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-12T05:32:41Z |
| publishDate | 2001-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-5b5819b0d7d64e7f94190dc61706e45d2022-12-22T00:36:16ZengBMCRespiratory Research1465-99212001-10-0131710.1186/rr179Interactions between genes and environmental factors in asthma and atopy: new developmentsSengler ClaudiaLau SusanneWahn UlrichNickel Renate<p>Abstract</p> <p>Asthma and associated phenotypes are complex traits most probably caused by an interaction of multiple disease susceptibility genes and environmental factors. Major achievements have occurred in identifying chromosomal regions and polymorphisms in candidate genes linked to or associated with asthma, atopic dermatitis, IgE levels and response to asthma therapy. The aims of this review are to explain the methodology of genetic studies of multifactorial diseases, to summarize chromosomal regions and polymorphisms in candidate genes linked to or associated with asthma and associated traits, to list genetic alterations that may alter response to asthma therapy, and to outline genetic factors that may render individuals more susceptible to asthma and atopy due to environmental changes.</p>http://dx.doi.org/10.1186/rr179asthmaatopyenvironmentgeneticsinfection |
| spellingShingle | Sengler Claudia Lau Susanne Wahn Ulrich Nickel Renate Interactions between genes and environmental factors in asthma and atopy: new developments Respiratory Research asthma atopy environment genetics infection |
| title | Interactions between genes and environmental factors in asthma and atopy: new developments |
| title_full | Interactions between genes and environmental factors in asthma and atopy: new developments |
| title_fullStr | Interactions between genes and environmental factors in asthma and atopy: new developments |
| title_full_unstemmed | Interactions between genes and environmental factors in asthma and atopy: new developments |
| title_short | Interactions between genes and environmental factors in asthma and atopy: new developments |
| title_sort | interactions between genes and environmental factors in asthma and atopy new developments |
| topic | asthma atopy environment genetics infection |
| url | http://dx.doi.org/10.1186/rr179 |
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