Allosensibilisation to erythrocyte antigens (literature review)
In this article literature review of the causes of allosensibilisation to erythrocyte antigens are presented. It is shown that the ability to produce antierythrocyte antibodies is affected by many factors, principal of whom it is difficult to identify. For the allosensibilisation development require...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2015-12-01
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| Series: | Онкогематология |
| Subjects: | |
| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/169 |
| _version_ | 1797855540142931968 |
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| author | N. V. Mineeva I. A. Pashkova I. I. Krobinets E. A. Sysoeva |
| author_facet | N. V. Mineeva I. A. Pashkova I. I. Krobinets E. A. Sysoeva |
| author_sort | N. V. Mineeva |
| collection | DOAJ |
| description | In this article literature review of the causes of allosensibilisation to erythrocyte antigens are presented. It is shown that the ability to produce antierythrocyte antibodies is affected by many factors, principal of whom it is difficult to identify. For the allosensibilisation development requires genetically determined differences in erythrocyte antigens phenotypes of donor and recipient, mother and fetus, which can lead to immune response and antibodies production. The biochemical nature of erythrocyte antigens, antigen dose (the amount of transfused doses, the number of antigens determinants on donor and fetus erythrocytes, the number of pregnancies) are important. Individual patient characteristics: age, gender, diseases, the use of immunosuppressive therapy and the presence of inflammatory processes, are also relevant. Note that antibody to one erythrocyte antigens have clinical value, and to the other – have no. The actual data about frequency of clinically significant antibodies contribute to the development of post-transfusion hemolytic complications prophylaxis as well as the improvement of laboratory diagnosis of hemolytic disease of the newborn in the presence of maternal antierythrocyte antibodies. |
| first_indexed | 2024-04-09T20:25:24Z |
| format | Article |
| id | doaj.art-5b59482f3a50489a9996993fe8411b7f |
| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:25:24Z |
| publishDate | 2015-12-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-5b59482f3a50489a9996993fe8411b7f2023-03-30T20:15:11ZrusABV-pressОнкогематология1818-83462413-40232015-12-01104606510.17650/1818-8346-2015-10-4-60-65181Allosensibilisation to erythrocyte antigens (literature review)N. V. Mineeva0I. A. Pashkova1I. I. Krobinets2E. A. Sysoeva3Russian Research Institute of Hematology and Transfusiology, Federal Medical and Biological AgencyResearch Institute – prof. S.V. Ochapovskiy Regional Clinical Hospital No 1Russian Research Institute of Hematology and Transfusiology, Federal Medical and Biological AgencyRussian Research Institute of Hematology and Transfusiology, Federal Medical and Biological AgencyIn this article literature review of the causes of allosensibilisation to erythrocyte antigens are presented. It is shown that the ability to produce antierythrocyte antibodies is affected by many factors, principal of whom it is difficult to identify. For the allosensibilisation development requires genetically determined differences in erythrocyte antigens phenotypes of donor and recipient, mother and fetus, which can lead to immune response and antibodies production. The biochemical nature of erythrocyte antigens, antigen dose (the amount of transfused doses, the number of antigens determinants on donor and fetus erythrocytes, the number of pregnancies) are important. Individual patient characteristics: age, gender, diseases, the use of immunosuppressive therapy and the presence of inflammatory processes, are also relevant. Note that antibody to one erythrocyte antigens have clinical value, and to the other – have no. The actual data about frequency of clinically significant antibodies contribute to the development of post-transfusion hemolytic complications prophylaxis as well as the improvement of laboratory diagnosis of hemolytic disease of the newborn in the presence of maternal antierythrocyte antibodies.https://oncohematology.abvpress.ru/ongm/article/view/169erythrocytesantigensclinical relevant antibodiesalloimmunisationtransfusionsdonortransfusion-dependent recipient |
| spellingShingle | N. V. Mineeva I. A. Pashkova I. I. Krobinets E. A. Sysoeva Allosensibilisation to erythrocyte antigens (literature review) Онкогематология erythrocytes antigens clinical relevant antibodies alloimmunisation transfusions donor transfusion-dependent recipient |
| title | Allosensibilisation to erythrocyte antigens (literature review) |
| title_full | Allosensibilisation to erythrocyte antigens (literature review) |
| title_fullStr | Allosensibilisation to erythrocyte antigens (literature review) |
| title_full_unstemmed | Allosensibilisation to erythrocyte antigens (literature review) |
| title_short | Allosensibilisation to erythrocyte antigens (literature review) |
| title_sort | allosensibilisation to erythrocyte antigens literature review |
| topic | erythrocytes antigens clinical relevant antibodies alloimmunisation transfusions donor transfusion-dependent recipient |
| url | https://oncohematology.abvpress.ru/ongm/article/view/169 |
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