Advances in synthetic approach to and antifungal activity of triazoles
Several five membered ring systems, e.g., triazole, oxadiazole dithiazole and thiadiazole with three heteroatoms at symmetrical or asymmetrical positions have been studied because of their interesting pharmacological properties. In this article our emphasis is on synthetic development and pharmacolo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Beilstein-Institut
2011-05-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.7.79 |
| _version_ | 1819275935537430528 |
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| author | Kumari Shalini Nitin Kumar Sushma Drabu Pramod Kumar Sharma |
| author_facet | Kumari Shalini Nitin Kumar Sushma Drabu Pramod Kumar Sharma |
| author_sort | Kumari Shalini |
| collection | DOAJ |
| description | Several five membered ring systems, e.g., triazole, oxadiazole dithiazole and thiadiazole with three heteroatoms at symmetrical or asymmetrical positions have been studied because of their interesting pharmacological properties. In this article our emphasis is on synthetic development and pharmacological activity of the triazole moiety which exhibit a broad spectrum of pharmacological activity such as antifungal, antibacterial, anti-inflammatory and anticancer etc. Triazoles have increased our ability to treat many fungal infections, for example, candidiasis, cryptococcal meningitis, aspergillosis etc. However, mortality due to these infections even with antifungal therapy is still unacceptably high. Therefore, the development of new antifungal agents targeting specific fungal structures or functions is being actively pursued. Rapid developments in molecular mycology have led to a concentrated search for more target antifungals. Although we are entering a new era of antifungal therapy in which we will continue to be challenged by systemic fungal diseases, the options for treatment will have greatly expanded. |
| first_indexed | 2024-12-23T23:32:14Z |
| format | Article |
| id | doaj.art-5b597f29ba1a4818b82bb627234e730d |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-23T23:32:14Z |
| publishDate | 2011-05-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-5b597f29ba1a4818b82bb627234e730d2022-12-21T17:26:00ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972011-05-017166867710.3762/bjoc.7.791860-5397-7-79Advances in synthetic approach to and antifungal activity of triazolesKumari Shalini0Nitin Kumar1Sushma Drabu2Pramod Kumar Sharma3Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Meerut, U. P., India, Pin-250005Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Meerut, U. P., India, Pin-250005Director, M.S.I.P., Janakpuri, New Delhi, IndiaDepartment of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Meerut, U. P., India, Pin-250005Several five membered ring systems, e.g., triazole, oxadiazole dithiazole and thiadiazole with three heteroatoms at symmetrical or asymmetrical positions have been studied because of their interesting pharmacological properties. In this article our emphasis is on synthetic development and pharmacological activity of the triazole moiety which exhibit a broad spectrum of pharmacological activity such as antifungal, antibacterial, anti-inflammatory and anticancer etc. Triazoles have increased our ability to treat many fungal infections, for example, candidiasis, cryptococcal meningitis, aspergillosis etc. However, mortality due to these infections even with antifungal therapy is still unacceptably high. Therefore, the development of new antifungal agents targeting specific fungal structures or functions is being actively pursued. Rapid developments in molecular mycology have led to a concentrated search for more target antifungals. Although we are entering a new era of antifungal therapy in which we will continue to be challenged by systemic fungal diseases, the options for treatment will have greatly expanded.https://doi.org/10.3762/bjoc.7.79antifungalaspergillosiscandidiasiscryptococcal meningitistriazole |
| spellingShingle | Kumari Shalini Nitin Kumar Sushma Drabu Pramod Kumar Sharma Advances in synthetic approach to and antifungal activity of triazoles Beilstein Journal of Organic Chemistry antifungal aspergillosis candidiasis cryptococcal meningitis triazole |
| title | Advances in synthetic approach to and antifungal activity of triazoles |
| title_full | Advances in synthetic approach to and antifungal activity of triazoles |
| title_fullStr | Advances in synthetic approach to and antifungal activity of triazoles |
| title_full_unstemmed | Advances in synthetic approach to and antifungal activity of triazoles |
| title_short | Advances in synthetic approach to and antifungal activity of triazoles |
| title_sort | advances in synthetic approach to and antifungal activity of triazoles |
| topic | antifungal aspergillosis candidiasis cryptococcal meningitis triazole |
| url | https://doi.org/10.3762/bjoc.7.79 |
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