The associations between central serous chorioretinopathy and muscle relaxants: A case–control study
PURPOSE: To evaluate the role of muscle-relaxants as risk factors for the development of central serous chorioretinopathy (CSC) - the second most common retinopathy in our settings; despite multiple risk factors seen in our patients, 21% were initially labelled as idiopathic. MATERIALS AND METHODS:...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Taiwan Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.e-tjo.org/article.asp?issn=2211-5056;year=2022;volume=12;issue=4;spage=415;epage=422;aulast=Jain |
| _version_ | 1811200239750610944 |
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| author | Manish Jain Sunir J Garg Mohammad Khan Varun Chaudhary Dena Zeraatkar Dhanya Kurian Sarath Lal |
| author_facet | Manish Jain Sunir J Garg Mohammad Khan Varun Chaudhary Dena Zeraatkar Dhanya Kurian Sarath Lal |
| author_sort | Manish Jain |
| collection | DOAJ |
| description | PURPOSE: To evaluate the role of muscle-relaxants as risk factors for the development of central serous chorioretinopathy (CSC) - the second most common retinopathy in our settings; despite multiple risk factors seen in our patients, 21% were initially labelled as idiopathic.
MATERIALS AND METHODS: Retrospective case-control study at a tertiary hospital in the United Arab Emirates, where we reviewed the medical records of 273 patients with CSC examined between 2010 and 2019 for use of muscle-relaxants including tolperisone/eperisone, carisoprodol and gabapentin/pregabalin within a year of onset/recurrence of the disease. Intake of drugs with known association with CSC (including corticosteroids/sympathomimetics) was also recorded. Two hundred eighty-six subjects with adverse events seen at the same institute during the same study period served as controls. Odds ratios, Chi-Square tests and multivariate logistic regression were carried out to determine any associations with the muscle-relaxants and other pharmacological confounders - corticosteroids/sympathomimetics.
RESULTS: Muscle relaxants may increase the risk of CSC as evident on multivariate regression analysis (OR: 2.55; confidence interval [CI]: 1.208-5.413); the significance was retained on removing the 6 subjects who had corticosteroids/sympathomimetics (OR: 2.30; CI: 1.073–4.939). Univariate analysis yielded an OR of 2.52 for muscle relaxants (CI: 1.2149–5.2276), 2.96 for eperisone/tolperisone (CI: 1.3531–6.5038), and 6.26 for eperisone as an individual agent (CI: 1.8146–21.6252).
CONCLUSION: We found muscle relaxants to be associated factors of CSC regardless of inclusion of corticosteroids/sympathomimetics (P < 0.05). Among individual classes of muscle relaxants in this study, only eperisone/tolperisone posed a significant risk (P < 0.05). The vascular smooth muscle relaxation could be the possible mechanism that affects the choroidal blood flow and indirectly predisposes to CSC. |
| first_indexed | 2024-04-12T02:01:13Z |
| format | Article |
| id | doaj.art-5b5b43a9a4bd46169a0cba73cfed681c |
| institution | Directory Open Access Journal |
| issn | 2211-5056 2211-5072 |
| language | English |
| last_indexed | 2024-04-12T02:01:13Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Taiwan Journal of Ophthalmology |
| spelling | doaj.art-5b5b43a9a4bd46169a0cba73cfed681c2022-12-22T03:52:40ZengWolters Kluwer Medknow PublicationsTaiwan Journal of Ophthalmology2211-50562211-50722022-01-0112441542210.4103/2211-5056.361975The associations between central serous chorioretinopathy and muscle relaxants: A case–control studyManish JainSunir J GargMohammad KhanVarun ChaudharyDena ZeraatkarDhanya KurianSarath LalPURPOSE: To evaluate the role of muscle-relaxants as risk factors for the development of central serous chorioretinopathy (CSC) - the second most common retinopathy in our settings; despite multiple risk factors seen in our patients, 21% were initially labelled as idiopathic. MATERIALS AND METHODS: Retrospective case-control study at a tertiary hospital in the United Arab Emirates, where we reviewed the medical records of 273 patients with CSC examined between 2010 and 2019 for use of muscle-relaxants including tolperisone/eperisone, carisoprodol and gabapentin/pregabalin within a year of onset/recurrence of the disease. Intake of drugs with known association with CSC (including corticosteroids/sympathomimetics) was also recorded. Two hundred eighty-six subjects with adverse events seen at the same institute during the same study period served as controls. Odds ratios, Chi-Square tests and multivariate logistic regression were carried out to determine any associations with the muscle-relaxants and other pharmacological confounders - corticosteroids/sympathomimetics. RESULTS: Muscle relaxants may increase the risk of CSC as evident on multivariate regression analysis (OR: 2.55; confidence interval [CI]: 1.208-5.413); the significance was retained on removing the 6 subjects who had corticosteroids/sympathomimetics (OR: 2.30; CI: 1.073–4.939). Univariate analysis yielded an OR of 2.52 for muscle relaxants (CI: 1.2149–5.2276), 2.96 for eperisone/tolperisone (CI: 1.3531–6.5038), and 6.26 for eperisone as an individual agent (CI: 1.8146–21.6252). CONCLUSION: We found muscle relaxants to be associated factors of CSC regardless of inclusion of corticosteroids/sympathomimetics (P < 0.05). Among individual classes of muscle relaxants in this study, only eperisone/tolperisone posed a significant risk (P < 0.05). The vascular smooth muscle relaxation could be the possible mechanism that affects the choroidal blood flow and indirectly predisposes to CSC.http://www.e-tjo.org/article.asp?issn=2211-5056;year=2022;volume=12;issue=4;spage=415;epage=422;aulast=Jaincarisoprodolcentral serous chorioretinopathyeperisonegabapentinmuscle relaxantspregabalintolperisone |
| spellingShingle | Manish Jain Sunir J Garg Mohammad Khan Varun Chaudhary Dena Zeraatkar Dhanya Kurian Sarath Lal The associations between central serous chorioretinopathy and muscle relaxants: A case–control study Taiwan Journal of Ophthalmology carisoprodol central serous chorioretinopathy eperisone gabapentin muscle relaxants pregabalin tolperisone |
| title | The associations between central serous chorioretinopathy and muscle relaxants: A case–control study |
| title_full | The associations between central serous chorioretinopathy and muscle relaxants: A case–control study |
| title_fullStr | The associations between central serous chorioretinopathy and muscle relaxants: A case–control study |
| title_full_unstemmed | The associations between central serous chorioretinopathy and muscle relaxants: A case–control study |
| title_short | The associations between central serous chorioretinopathy and muscle relaxants: A case–control study |
| title_sort | associations between central serous chorioretinopathy and muscle relaxants a case control study |
| topic | carisoprodol central serous chorioretinopathy eperisone gabapentin muscle relaxants pregabalin tolperisone |
| url | http://www.e-tjo.org/article.asp?issn=2211-5056;year=2022;volume=12;issue=4;spage=415;epage=422;aulast=Jain |
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