Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts Alleviate Abnormal Hepatic Lipid Metabolism without Suppression of Glucose Intolerance in a Streptozotocin/Nicotinamide-Induced Diabetic Rat Model
This study was designed to investigate the effects of polysaccharide-rich red algae (<i>Gelidium amansii</i>) hot-water extracts (GHE) on lipid and glucose metabolism in rats with streptozotocin (STZ)/nicotinamide (NA)-induced diabetes. Rats were divided into three groups: NC—normal cont...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/4/1447 |
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| author | Shing-Hwa Liu Chia-Yu Ku Meng-Tsan Chiang |
| author_facet | Shing-Hwa Liu Chia-Yu Ku Meng-Tsan Chiang |
| author_sort | Shing-Hwa Liu |
| collection | DOAJ |
| description | This study was designed to investigate the effects of polysaccharide-rich red algae (<i>Gelidium amansii</i>) hot-water extracts (GHE) on lipid and glucose metabolism in rats with streptozotocin (STZ)/nicotinamide (NA)-induced diabetes. Rats were divided into three groups: NC—normal control group), DM—diabetic group, and DG—diabetic group supplemented with GHE (5%). The experimental diet and drinking water were available ad libitum for 10 weeks. After the 10-week feeding duration, the body weight, liver weight, total adipose tissue weight, and hepatic TBARS and cholesterol levels were significantly increased, and hepatic glycogen content and adipose lipolysis rate were significantly decreased in the DM group, which could be effectively reversed by supplementation of GHE. However, GHE supplementation could not improve the glucose intolerance in DM rats. It was interesting to note that GHE supplementation could decrease the liver glucose-6-phosphotase activity, which was increased in DM rats. Taken together, these results suggested that GHE feeding may ameliorate abnormal hepatic lipid metabolism, but not glucose intolerance, in diabetic rats induced by STZ/NA. |
| first_indexed | 2024-03-09T21:19:44Z |
| format | Article |
| id | doaj.art-5b5b57515dbf4080b247b237e89245d7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:19:44Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5b5b57515dbf4080b247b237e89245d72023-11-23T21:24:09ZengMDPI AGMolecules1420-30492022-02-01274144710.3390/molecules27041447Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts Alleviate Abnormal Hepatic Lipid Metabolism without Suppression of Glucose Intolerance in a Streptozotocin/Nicotinamide-Induced Diabetic Rat ModelShing-Hwa Liu0Chia-Yu Ku1Meng-Tsan Chiang2Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, TaiwanDepartment of Food Science, National Taiwan Ocean University, Keelung 20224, TaiwanDepartment of Food Science, National Taiwan Ocean University, Keelung 20224, TaiwanThis study was designed to investigate the effects of polysaccharide-rich red algae (<i>Gelidium amansii</i>) hot-water extracts (GHE) on lipid and glucose metabolism in rats with streptozotocin (STZ)/nicotinamide (NA)-induced diabetes. Rats were divided into three groups: NC—normal control group), DM—diabetic group, and DG—diabetic group supplemented with GHE (5%). The experimental diet and drinking water were available ad libitum for 10 weeks. After the 10-week feeding duration, the body weight, liver weight, total adipose tissue weight, and hepatic TBARS and cholesterol levels were significantly increased, and hepatic glycogen content and adipose lipolysis rate were significantly decreased in the DM group, which could be effectively reversed by supplementation of GHE. However, GHE supplementation could not improve the glucose intolerance in DM rats. It was interesting to note that GHE supplementation could decrease the liver glucose-6-phosphotase activity, which was increased in DM rats. Taken together, these results suggested that GHE feeding may ameliorate abnormal hepatic lipid metabolism, but not glucose intolerance, in diabetic rats induced by STZ/NA.https://www.mdpi.com/1420-3049/27/4/1447red algae hot-water extractspolysaccharide-richdiabetic ratsglucose metabolism |
| spellingShingle | Shing-Hwa Liu Chia-Yu Ku Meng-Tsan Chiang Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts Alleviate Abnormal Hepatic Lipid Metabolism without Suppression of Glucose Intolerance in a Streptozotocin/Nicotinamide-Induced Diabetic Rat Model Molecules red algae hot-water extracts polysaccharide-rich diabetic rats glucose metabolism |
| title | Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts Alleviate Abnormal Hepatic Lipid Metabolism without Suppression of Glucose Intolerance in a Streptozotocin/Nicotinamide-Induced Diabetic Rat Model |
| title_full | Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts Alleviate Abnormal Hepatic Lipid Metabolism without Suppression of Glucose Intolerance in a Streptozotocin/Nicotinamide-Induced Diabetic Rat Model |
| title_fullStr | Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts Alleviate Abnormal Hepatic Lipid Metabolism without Suppression of Glucose Intolerance in a Streptozotocin/Nicotinamide-Induced Diabetic Rat Model |
| title_full_unstemmed | Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts Alleviate Abnormal Hepatic Lipid Metabolism without Suppression of Glucose Intolerance in a Streptozotocin/Nicotinamide-Induced Diabetic Rat Model |
| title_short | Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts Alleviate Abnormal Hepatic Lipid Metabolism without Suppression of Glucose Intolerance in a Streptozotocin/Nicotinamide-Induced Diabetic Rat Model |
| title_sort | polysaccharide rich red algae i gelidium amansii i hot water extracts alleviate abnormal hepatic lipid metabolism without suppression of glucose intolerance in a streptozotocin nicotinamide induced diabetic rat model |
| topic | red algae hot-water extracts polysaccharide-rich diabetic rats glucose metabolism |
| url | https://www.mdpi.com/1420-3049/27/4/1447 |
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