<i>Aspergillus flavus</i> as a Model System to Test the Biological Activity of Botanicals: An Example on <i>Citrullus colocynthis</i> L. Schrad. Organic Extracts
<i>Citrullus colocynthis</i> L. Schrader is an annual plant belonging to the Cucurbitaceae family, widely distributed in the desert areas of the Mediterranean basin. Many pharmacological properties (anti-inflammatory, anti-diabetic, analgesic, anti-epileptic) are ascribed to different or...
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| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/11/5/286 |
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| author | Francesca Degola Belsem Marzouk Antonella Gori Cecilia Brunetti Lucia Dramis Stefania Gelati Annamaria Buschini Francesco M. Restivo |
| author_facet | Francesca Degola Belsem Marzouk Antonella Gori Cecilia Brunetti Lucia Dramis Stefania Gelati Annamaria Buschini Francesco M. Restivo |
| author_sort | Francesca Degola |
| collection | DOAJ |
| description | <i>Citrullus colocynthis</i> L. Schrader is an annual plant belonging to the Cucurbitaceae family, widely distributed in the desert areas of the Mediterranean basin. Many pharmacological properties (anti-inflammatory, anti-diabetic, analgesic, anti-epileptic) are ascribed to different organs of this plant; extracts and derivatives of <i>C. colocynthis</i> are used in folk Berber medicine for the treatment of numerous diseases—such as rheumatism arthritis, hypertension bronchitis, mastitis, and even cancer. Clinical studies aimed at confirming the chemical and biological bases of pharmacological activity assigned to many plant/herb extracts used in folk medicine often rely on results obtained from laboratory preliminary tests. We investigated the biological activity of some <i>C. colocynthis</i> stem, leaf, and root extracts on the mycotoxigenic and phytopathogenic fungus <i>Aspergillus flavus</i>, testing a possible correlation between the inhibitory effect on aflatoxin biosynthesis, the phytochemical composition of extracts, and their in vitro antioxidant capacities. |
| first_indexed | 2024-12-10T08:05:30Z |
| format | Article |
| id | doaj.art-5b5bfed9297745de9e9a9485df2d8d19 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-12-10T08:05:30Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-5b5bfed9297745de9e9a9485df2d8d192022-12-22T01:56:41ZengMDPI AGToxins2072-66512019-05-0111528610.3390/toxins11050286toxins11050286<i>Aspergillus flavus</i> as a Model System to Test the Biological Activity of Botanicals: An Example on <i>Citrullus colocynthis</i> L. Schrad. Organic ExtractsFrancesca Degola0Belsem Marzouk1Antonella Gori2Cecilia Brunetti3Lucia Dramis4Stefania Gelati5Annamaria Buschini6Francesco M. Restivo7Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, ItalyLaboratory of Chemical, Galenic and Pharmacological Development of Drugs, Faculty of Pharmacy of Monastir, University of Monastir, 5000 Monastir, TunisiaTree and Timber Institute (IVALSA), National Research Council of Italy (CNR), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, ItalyTree and Timber Institute (IVALSA), National Research Council of Italy (CNR), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, ItalyDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, ItalyDepartment of Packaging, Experimental Station for the Food Preserving Industry (SSICA), Viale Tanara 31/A, 43121 Parma, ItalyDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, ItalyDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy<i>Citrullus colocynthis</i> L. Schrader is an annual plant belonging to the Cucurbitaceae family, widely distributed in the desert areas of the Mediterranean basin. Many pharmacological properties (anti-inflammatory, anti-diabetic, analgesic, anti-epileptic) are ascribed to different organs of this plant; extracts and derivatives of <i>C. colocynthis</i> are used in folk Berber medicine for the treatment of numerous diseases—such as rheumatism arthritis, hypertension bronchitis, mastitis, and even cancer. Clinical studies aimed at confirming the chemical and biological bases of pharmacological activity assigned to many plant/herb extracts used in folk medicine often rely on results obtained from laboratory preliminary tests. We investigated the biological activity of some <i>C. colocynthis</i> stem, leaf, and root extracts on the mycotoxigenic and phytopathogenic fungus <i>Aspergillus flavus</i>, testing a possible correlation between the inhibitory effect on aflatoxin biosynthesis, the phytochemical composition of extracts, and their in vitro antioxidant capacities.https://www.mdpi.com/2072-6651/11/5/286antimycotoxigenic activity<i>Citrullus colocynthis</i><i>Aspergillus flavus</i>model systemHPLC-MS/MS |
| spellingShingle | Francesca Degola Belsem Marzouk Antonella Gori Cecilia Brunetti Lucia Dramis Stefania Gelati Annamaria Buschini Francesco M. Restivo <i>Aspergillus flavus</i> as a Model System to Test the Biological Activity of Botanicals: An Example on <i>Citrullus colocynthis</i> L. Schrad. Organic Extracts Toxins antimycotoxigenic activity <i>Citrullus colocynthis</i> <i>Aspergillus flavus</i> model system HPLC-MS/MS |
| title | <i>Aspergillus flavus</i> as a Model System to Test the Biological Activity of Botanicals: An Example on <i>Citrullus colocynthis</i> L. Schrad. Organic Extracts |
| title_full | <i>Aspergillus flavus</i> as a Model System to Test the Biological Activity of Botanicals: An Example on <i>Citrullus colocynthis</i> L. Schrad. Organic Extracts |
| title_fullStr | <i>Aspergillus flavus</i> as a Model System to Test the Biological Activity of Botanicals: An Example on <i>Citrullus colocynthis</i> L. Schrad. Organic Extracts |
| title_full_unstemmed | <i>Aspergillus flavus</i> as a Model System to Test the Biological Activity of Botanicals: An Example on <i>Citrullus colocynthis</i> L. Schrad. Organic Extracts |
| title_short | <i>Aspergillus flavus</i> as a Model System to Test the Biological Activity of Botanicals: An Example on <i>Citrullus colocynthis</i> L. Schrad. Organic Extracts |
| title_sort | i aspergillus flavus i as a model system to test the biological activity of botanicals an example on i citrullus colocynthis i l schrad organic extracts |
| topic | antimycotoxigenic activity <i>Citrullus colocynthis</i> <i>Aspergillus flavus</i> model system HPLC-MS/MS |
| url | https://www.mdpi.com/2072-6651/11/5/286 |
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