Use of risedronate for consolidation and callus formation in Colles fractures in postmenopausal women: SOLID study
OBJECTIVE: This open, randomized and blinded parallel-group multicenter study evaluated the efficacy of Actonel(r) (35 mg) plus calcium/vitamin D versus calcium/vitamin D alone for preserving bone mineral density (BMD) in postmenopausal women with Colles fractures.METHODS: Patients with a Colles fra...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Ortopedia e Traumatologia
2015-06-01
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| Series: | Revista Brasileira de Ortopedia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162015000300274&lng=en&tlng=en |
| _version_ | 1797329533199712256 |
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| author | Lindomar Guimarães Oliveira Sérgio Ragi Eis Henrique Mota Neto Frederico Barra de Moraes Luiz Antônio Silveira Simões Pires José Wanderley Vasconcelos |
| author_facet | Lindomar Guimarães Oliveira Sérgio Ragi Eis Henrique Mota Neto Frederico Barra de Moraes Luiz Antônio Silveira Simões Pires José Wanderley Vasconcelos |
| author_sort | Lindomar Guimarães Oliveira |
| collection | DOAJ |
| description | OBJECTIVE: This open, randomized and blinded parallel-group multicenter study evaluated the efficacy of Actonel(r) (35 mg) plus calcium/vitamin D versus calcium/vitamin D alone for preserving bone mineral density (BMD) in postmenopausal women with Colles fractures.METHODS: Patients with a Colles fracture for seven days were randomized to receive either Actonel(r) (35 mg) once a week plus calcium/vitamin D (ACD group) or calcium/vitamin D alone (CD group). The patients were evaluated after 90 and 180 days of treatment.RESULTS: 59 ACD patients and 56 CD patients completed all the evaluations. At the end of the study, the BMD of the radius at the fracture location showed a negative change in the CD group (32.8%). The loss of BMD in the ACD group (20.8%) was slightly less than that in the CD group. There was a difference in the proportions of patients with BMD losses at the end of the study period in the two treatment groups, in favor of the ACD group, although this was not statistically significant. There was no significant difference in radiological identification of callus formation between the treatment groups. In the majority of the patients, the callus could be radiologically identified after 90 days.CONCLUSION: Postmenopausal women with Colles fractures who received risedronate sodium plus calcium/vitamin D did not show any significant difference in BMD loss in forearm fractures, in comparison with those who received calcium/vitamin D alone. Risedronate presented a tendency toward a protective effect regarding BMD loss due to immobilization. The time taken for fracture consolidation to be achieved was unaffected. |
| first_indexed | 2024-03-08T07:06:39Z |
| format | Article |
| id | doaj.art-5b5c062467914f87b258d823734d7318 |
| institution | Directory Open Access Journal |
| issn | 1982-4378 |
| language | English |
| last_indexed | 2024-03-08T07:06:39Z |
| publishDate | 2015-06-01 |
| publisher | Sociedade Brasileira de Ortopedia e Traumatologia |
| record_format | Article |
| series | Revista Brasileira de Ortopedia |
| spelling | doaj.art-5b5c062467914f87b258d823734d73182024-02-03T04:23:53ZengSociedade Brasileira de Ortopedia e TraumatologiaRevista Brasileira de Ortopedia1982-43782015-06-0150327428210.1016/j.rboe.2015.04.004S0102-36162015000300274Use of risedronate for consolidation and callus formation in Colles fractures in postmenopausal women: SOLID studyLindomar Guimarães OliveiraSérgio Ragi EisHenrique Mota NetoFrederico Barra de MoraesLuiz Antônio Silveira Simões PiresJosé Wanderley VasconcelosOBJECTIVE: This open, randomized and blinded parallel-group multicenter study evaluated the efficacy of Actonel(r) (35 mg) plus calcium/vitamin D versus calcium/vitamin D alone for preserving bone mineral density (BMD) in postmenopausal women with Colles fractures.METHODS: Patients with a Colles fracture for seven days were randomized to receive either Actonel(r) (35 mg) once a week plus calcium/vitamin D (ACD group) or calcium/vitamin D alone (CD group). The patients were evaluated after 90 and 180 days of treatment.RESULTS: 59 ACD patients and 56 CD patients completed all the evaluations. At the end of the study, the BMD of the radius at the fracture location showed a negative change in the CD group (32.8%). The loss of BMD in the ACD group (20.8%) was slightly less than that in the CD group. There was a difference in the proportions of patients with BMD losses at the end of the study period in the two treatment groups, in favor of the ACD group, although this was not statistically significant. There was no significant difference in radiological identification of callus formation between the treatment groups. In the majority of the patients, the callus could be radiologically identified after 90 days.CONCLUSION: Postmenopausal women with Colles fractures who received risedronate sodium plus calcium/vitamin D did not show any significant difference in BMD loss in forearm fractures, in comparison with those who received calcium/vitamin D alone. Risedronate presented a tendency toward a protective effect regarding BMD loss due to immobilization. The time taken for fracture consolidation to be achieved was unaffected.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162015000300274&lng=en&tlng=enConsolidação da fraturaFratura de CollesDifosfonatos |
| spellingShingle | Lindomar Guimarães Oliveira Sérgio Ragi Eis Henrique Mota Neto Frederico Barra de Moraes Luiz Antônio Silveira Simões Pires José Wanderley Vasconcelos Use of risedronate for consolidation and callus formation in Colles fractures in postmenopausal women: SOLID study Revista Brasileira de Ortopedia Consolidação da fratura Fratura de Colles Difosfonatos |
| title | Use of risedronate for consolidation and callus formation in Colles fractures in postmenopausal women: SOLID study |
| title_full | Use of risedronate for consolidation and callus formation in Colles fractures in postmenopausal women: SOLID study |
| title_fullStr | Use of risedronate for consolidation and callus formation in Colles fractures in postmenopausal women: SOLID study |
| title_full_unstemmed | Use of risedronate for consolidation and callus formation in Colles fractures in postmenopausal women: SOLID study |
| title_short | Use of risedronate for consolidation and callus formation in Colles fractures in postmenopausal women: SOLID study |
| title_sort | use of risedronate for consolidation and callus formation in colles fractures in postmenopausal women solid study |
| topic | Consolidação da fratura Fratura de Colles Difosfonatos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162015000300274&lng=en&tlng=en |
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