Myxobacteria as a Source of New Bioactive Compounds: A Perspective Study
Myxobacteria are unicellular, Gram-negative, soil-dwelling, gliding bacteria that belong to class δ-proteobacteria and order <i>Myxococcales.</i> They grow and proliferate by transverse fission under normal conditions, but form fruiting bodies which contain myxospores during unfavorable...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/8/1265 |
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| author | Mudasir Ahmad Bhat Awdhesh Kumar Mishra Mujtaba Aamir Bhat Mohammad Iqbal Banday Ommer Bashir Irfan A. Rather Safikur Rahman Ali Asghar Shah Arif Tasleem Jan |
| author_facet | Mudasir Ahmad Bhat Awdhesh Kumar Mishra Mujtaba Aamir Bhat Mohammad Iqbal Banday Ommer Bashir Irfan A. Rather Safikur Rahman Ali Asghar Shah Arif Tasleem Jan |
| author_sort | Mudasir Ahmad Bhat |
| collection | DOAJ |
| description | Myxobacteria are unicellular, Gram-negative, soil-dwelling, gliding bacteria that belong to class δ-proteobacteria and order <i>Myxococcales.</i> They grow and proliferate by transverse fission under normal conditions, but form fruiting bodies which contain myxospores during unfavorable conditions. In view of the escalating problem of antibiotic resistance among disease-causing pathogens, it becomes mandatory to search for new antibiotics effective against such pathogens from natural sources. Among the different approaches, Myxobacteria, having a rich armor of secondary metabolites, preferably derivatives of polyketide synthases (PKSs) along with non-ribosomal peptide synthases (NRPSs) and their hybrids, are currently being explored as producers of new antibiotics. The <i>Myxobacterial</i> species are functionally characterized to assess their ability to produce antibacterial, antifungal, anticancer, antimalarial, immunosuppressive, cytotoxic and antioxidative bioactive compounds. In our study, we have found their compounds to be effective against a wide range of pathogens associated with the concurrence of different infectious diseases. |
| first_indexed | 2024-03-10T08:28:17Z |
| format | Article |
| id | doaj.art-5b622986269743fcb50678df8a54a6fb |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T08:28:17Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-5b622986269743fcb50678df8a54a6fb2023-11-22T09:15:13ZengMDPI AGPharmaceutics1999-49232021-08-01138126510.3390/pharmaceutics13081265Myxobacteria as a Source of New Bioactive Compounds: A Perspective StudyMudasir Ahmad Bhat0Awdhesh Kumar Mishra1Mujtaba Aamir Bhat2Mohammad Iqbal Banday3Ommer Bashir4Irfan A. Rather5Safikur Rahman6Ali Asghar Shah7Arif Tasleem Jan8Department of Biotechnology, Baba Ghulam Shah Badshah University, Rajouri 185234, Jammu and Kashmir, IndiaDepartment of Biotechnology, Yeungnam University, Gyeongsan 38541, KoreaDepartment of Botany, Baba Ghulam Shah Badshah University, Rajouri 185234, Jammu and Kashmir, IndiaDepartment of Microbiology, Baba Ghulam Shah Badshah University, Rajouri 185234, Jammu and Kashmir, IndiaDepartment of School Education, Jammu 181205, Jammu and Kashmir, IndiaDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University (KAU), Jeddah 21589, Saudi ArabiaDepartment of Botany, MS College, BR Ambedkar Bihar University, Muzaffarpur 845401, Bihar, IndiaDepartment of Biotechnology, Baba Ghulam Shah Badshah University, Rajouri 185234, Jammu and Kashmir, IndiaDepartment of Botany, Baba Ghulam Shah Badshah University, Rajouri 185234, Jammu and Kashmir, IndiaMyxobacteria are unicellular, Gram-negative, soil-dwelling, gliding bacteria that belong to class δ-proteobacteria and order <i>Myxococcales.</i> They grow and proliferate by transverse fission under normal conditions, but form fruiting bodies which contain myxospores during unfavorable conditions. In view of the escalating problem of antibiotic resistance among disease-causing pathogens, it becomes mandatory to search for new antibiotics effective against such pathogens from natural sources. Among the different approaches, Myxobacteria, having a rich armor of secondary metabolites, preferably derivatives of polyketide synthases (PKSs) along with non-ribosomal peptide synthases (NRPSs) and their hybrids, are currently being explored as producers of new antibiotics. The <i>Myxobacterial</i> species are functionally characterized to assess their ability to produce antibacterial, antifungal, anticancer, antimalarial, immunosuppressive, cytotoxic and antioxidative bioactive compounds. In our study, we have found their compounds to be effective against a wide range of pathogens associated with the concurrence of different infectious diseases.https://www.mdpi.com/1999-4923/13/8/1265antibioticsbioactive compoundsmedicationMyxobacteriahuman diseases |
| spellingShingle | Mudasir Ahmad Bhat Awdhesh Kumar Mishra Mujtaba Aamir Bhat Mohammad Iqbal Banday Ommer Bashir Irfan A. Rather Safikur Rahman Ali Asghar Shah Arif Tasleem Jan Myxobacteria as a Source of New Bioactive Compounds: A Perspective Study Pharmaceutics antibiotics bioactive compounds medication Myxobacteria human diseases |
| title | Myxobacteria as a Source of New Bioactive Compounds: A Perspective Study |
| title_full | Myxobacteria as a Source of New Bioactive Compounds: A Perspective Study |
| title_fullStr | Myxobacteria as a Source of New Bioactive Compounds: A Perspective Study |
| title_full_unstemmed | Myxobacteria as a Source of New Bioactive Compounds: A Perspective Study |
| title_short | Myxobacteria as a Source of New Bioactive Compounds: A Perspective Study |
| title_sort | myxobacteria as a source of new bioactive compounds a perspective study |
| topic | antibiotics bioactive compounds medication Myxobacteria human diseases |
| url | https://www.mdpi.com/1999-4923/13/8/1265 |
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