Novel Insights Into Pathogenesis and Therapeutic Strategies of Hepatic Encephalopathy, From the Gut Microbiota Perspective
Since the 1950s, gradual changes in the gut microbiota of patients with hepatic encephalopathy have been observed. Previous research has indicated potential associations between the gut and brain, and the gut microbiota is becoming a hot topic in research on diseases of the nervous system. However,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.586427/full |
| _version_ | 1819050484210597888 |
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| author | Jiachen Liu Yantao Xu Bimei Jiang |
| author_facet | Jiachen Liu Yantao Xu Bimei Jiang |
| author_sort | Jiachen Liu |
| collection | DOAJ |
| description | Since the 1950s, gradual changes in the gut microbiota of patients with hepatic encephalopathy have been observed. Previous research has indicated potential associations between the gut and brain, and the gut microbiota is becoming a hot topic in research on diseases of the nervous system. However, for the past few decades, studies of hepatic encephalopathy have been restricted to controlling the gut microbiota during macroscopic manipulation, such as probiotic intervention, while its clinical use remains controversial, and the cellular mechanisms underlying this condition are still poorly understood. This thesis seeks to comprehensively understand and explain the role of gut microbiota in hepatic encephalopathy as well as analyze the effects of intervention by regulating the gut microbiota. Evidence is presented that shows that dysbiosis of the gut microbiota is the primary pathological driver of hepatic encephalopathy and impacts pathologic progression via complex regulatory networks. As a result, suggestions were identified for future mechanistic research and improvements in therapeutic strategies for hepatic encephalopathy. |
| first_indexed | 2024-12-21T11:48:47Z |
| format | Article |
| id | doaj.art-5b62a20099a541be9b7374f57196c91e |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-21T11:48:47Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-5b62a20099a541be9b7374f57196c91e2022-12-21T19:05:07ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-02-011110.3389/fcimb.2021.586427586427Novel Insights Into Pathogenesis and Therapeutic Strategies of Hepatic Encephalopathy, From the Gut Microbiota PerspectiveJiachen Liu0Yantao Xu1Bimei Jiang2Xiangya Medical College of Central South University, Changsha, ChinaXiangya Medical College of Central South University, Changsha, ChinaDepartment of Pathophysiology, Sepsis Translational Medicine Key Laboratory of Hunan Province, Xiangya School of Medicine, Central South University, Changsha, ChinaSince the 1950s, gradual changes in the gut microbiota of patients with hepatic encephalopathy have been observed. Previous research has indicated potential associations between the gut and brain, and the gut microbiota is becoming a hot topic in research on diseases of the nervous system. However, for the past few decades, studies of hepatic encephalopathy have been restricted to controlling the gut microbiota during macroscopic manipulation, such as probiotic intervention, while its clinical use remains controversial, and the cellular mechanisms underlying this condition are still poorly understood. This thesis seeks to comprehensively understand and explain the role of gut microbiota in hepatic encephalopathy as well as analyze the effects of intervention by regulating the gut microbiota. Evidence is presented that shows that dysbiosis of the gut microbiota is the primary pathological driver of hepatic encephalopathy and impacts pathologic progression via complex regulatory networks. As a result, suggestions were identified for future mechanistic research and improvements in therapeutic strategies for hepatic encephalopathy.https://www.frontiersin.org/articles/10.3389/fcimb.2021.586427/fullgut microbiotahepatic encephalopathygut–liver–brain axisprobioticfecal microbiota transplantationantibiotics |
| spellingShingle | Jiachen Liu Yantao Xu Bimei Jiang Novel Insights Into Pathogenesis and Therapeutic Strategies of Hepatic Encephalopathy, From the Gut Microbiota Perspective Frontiers in Cellular and Infection Microbiology gut microbiota hepatic encephalopathy gut–liver–brain axis probiotic fecal microbiota transplantation antibiotics |
| title | Novel Insights Into Pathogenesis and Therapeutic Strategies of Hepatic Encephalopathy, From the Gut Microbiota Perspective |
| title_full | Novel Insights Into Pathogenesis and Therapeutic Strategies of Hepatic Encephalopathy, From the Gut Microbiota Perspective |
| title_fullStr | Novel Insights Into Pathogenesis and Therapeutic Strategies of Hepatic Encephalopathy, From the Gut Microbiota Perspective |
| title_full_unstemmed | Novel Insights Into Pathogenesis and Therapeutic Strategies of Hepatic Encephalopathy, From the Gut Microbiota Perspective |
| title_short | Novel Insights Into Pathogenesis and Therapeutic Strategies of Hepatic Encephalopathy, From the Gut Microbiota Perspective |
| title_sort | novel insights into pathogenesis and therapeutic strategies of hepatic encephalopathy from the gut microbiota perspective |
| topic | gut microbiota hepatic encephalopathy gut–liver–brain axis probiotic fecal microbiota transplantation antibiotics |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.586427/full |
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