Glucose Serum Concentrations and Cardiovascular Disease in Patients on the End Stage of Renal Disease without Diabetes Mellitus

Background/Aim: It is still controversial whether tighter glycemic control is associated with better clinical outcomes in patients with kidney failure. We examined the association between glucose serum concentrations and cardiovascular disease in patients on the end stage of renal disease without di...

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Main Authors: Vaia D. Raikou, Despina Kyriaki
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
Online Access:http://www.mdpi.com/2308-3425/2/2/66
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author Vaia D. Raikou
Despina Kyriaki
author_facet Vaia D. Raikou
Despina Kyriaki
author_sort Vaia D. Raikou
collection DOAJ
description Background/Aim: It is still controversial whether tighter glycemic control is associated with better clinical outcomes in patients with kidney failure. We examined the association between glucose serum concentrations and cardiovascular disease in patients on the end stage of renal disease without diabetes mellitus. Methods: We studied 76 patients on on-line hemodiafiltration. Cardiovascular disease was defined by the existence of coronary disease (CD). Arterial stiffness was measured as carotid-femoral pulse wave velocity (c-fPWV) and carotid augmentation index (AIx). The concentrations of beta2-microglobulin (β2M) and insulin were measured by radioimmunoassays and insulin resistance by HOMA-IR. We built a logistic-regression analysis to examine the role of glucose on cardiovascular disease after adjustment for the traditional and specific risk factors for dialysis patients. Results: Serum glucose was positively correlated with beta2M, insulin and HOMA-IR (r = 0.361, p = 0.002, r = 0.581, p = 0.001 and r = 0.753, p = 0.001 respectively). Logistic-regression analysis did not show significant impact of glucose concentrations on cardiovascular disease after adjustment for traditional and specific risk factors. Conclusions: The association between elevated glucose serum concentrations and represented by coronary syndrome cardiovascular disease in patients on the end stage of renal disease without diabetes mellitus was not found significant.
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spelling doaj.art-5b632a83c2eb472cbc27dd377089aea32022-12-21T18:46:16ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252015-04-0122667510.3390/jcdd2020066jcdd2020066Glucose Serum Concentrations and Cardiovascular Disease in Patients on the End Stage of Renal Disease without Diabetes MellitusVaia D. Raikou0Despina Kyriaki1Department of Medicine—Propaedaetic, National and Kapodistrian University of Athens, School of Medicine, Athens, 11527, GreeceDepartment of Nuclear Medicine, General Hospital "LAΪKO", Αthens, 11527, GreeceBackground/Aim: It is still controversial whether tighter glycemic control is associated with better clinical outcomes in patients with kidney failure. We examined the association between glucose serum concentrations and cardiovascular disease in patients on the end stage of renal disease without diabetes mellitus. Methods: We studied 76 patients on on-line hemodiafiltration. Cardiovascular disease was defined by the existence of coronary disease (CD). Arterial stiffness was measured as carotid-femoral pulse wave velocity (c-fPWV) and carotid augmentation index (AIx). The concentrations of beta2-microglobulin (β2M) and insulin were measured by radioimmunoassays and insulin resistance by HOMA-IR. We built a logistic-regression analysis to examine the role of glucose on cardiovascular disease after adjustment for the traditional and specific risk factors for dialysis patients. Results: Serum glucose was positively correlated with beta2M, insulin and HOMA-IR (r = 0.361, p = 0.002, r = 0.581, p = 0.001 and r = 0.753, p = 0.001 respectively). Logistic-regression analysis did not show significant impact of glucose concentrations on cardiovascular disease after adjustment for traditional and specific risk factors. Conclusions: The association between elevated glucose serum concentrations and represented by coronary syndrome cardiovascular disease in patients on the end stage of renal disease without diabetes mellitus was not found significant.http://www.mdpi.com/2308-3425/2/2/66glucoseHOMA-IRcardiovascular diseasehemodiafiltration
spellingShingle Vaia D. Raikou
Despina Kyriaki
Glucose Serum Concentrations and Cardiovascular Disease in Patients on the End Stage of Renal Disease without Diabetes Mellitus
Journal of Cardiovascular Development and Disease
glucose
HOMA-IR
cardiovascular disease
hemodiafiltration
title Glucose Serum Concentrations and Cardiovascular Disease in Patients on the End Stage of Renal Disease without Diabetes Mellitus
title_full Glucose Serum Concentrations and Cardiovascular Disease in Patients on the End Stage of Renal Disease without Diabetes Mellitus
title_fullStr Glucose Serum Concentrations and Cardiovascular Disease in Patients on the End Stage of Renal Disease without Diabetes Mellitus
title_full_unstemmed Glucose Serum Concentrations and Cardiovascular Disease in Patients on the End Stage of Renal Disease without Diabetes Mellitus
title_short Glucose Serum Concentrations and Cardiovascular Disease in Patients on the End Stage of Renal Disease without Diabetes Mellitus
title_sort glucose serum concentrations and cardiovascular disease in patients on the end stage of renal disease without diabetes mellitus
topic glucose
HOMA-IR
cardiovascular disease
hemodiafiltration
url http://www.mdpi.com/2308-3425/2/2/66
work_keys_str_mv AT vaiadraikou glucoseserumconcentrationsandcardiovasculardiseaseinpatientsontheendstageofrenaldiseasewithoutdiabetesmellitus
AT despinakyriaki glucoseserumconcentrationsandcardiovasculardiseaseinpatientsontheendstageofrenaldiseasewithoutdiabetesmellitus