Liquid-Based Cytology of the Cerebrospinal Fluid in a Case of Cryptococcal Meningitis
Cryptococcus neoformans is the most common microorganism found in cerebrospinal fluid (CSF) cytology and causes life-threatening infections in immunocompromised hosts. Although its cytomorphologic features in conventional smear cytology have been well described, those in liquid-based cytology have r...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2018-01-01
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| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2017-06-13.pdf |
| _version_ | 1819067494757826560 |
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| author | Jiwoon Choi Se Hoon Kim |
| author_facet | Jiwoon Choi Se Hoon Kim |
| author_sort | Jiwoon Choi |
| collection | DOAJ |
| description | Cryptococcus neoformans is the most common microorganism found in cerebrospinal fluid (CSF) cytology and causes life-threatening infections in immunocompromised hosts. Although its cytomorphologic features in conventional smear cytology have been well described, those in liquid-based cytology have rarely been. A 73-year-old woman with diffuse large B-cell lymphoma presented with mental confusion and a spiking fever. To rule out infectious conditions, CSF examination was performed. A cytology slide that was prepared using the ThinPrep method showed numerous spherical yeast-form organisms with diameters of 4–11 μm and thick capsules. Occasional asymmetrical, narrow-based budding but no true hyphae or pseudohyphae were observed. Gomori methenamine silver staining was positive. Cryptococcosis was confirmed in blood and CSF through the cryptococcal antigen test and culture. Liquid-based cytology allows for a clean background and additional slides for ancillary testing, facilitating the detection of microorganisms in CSF specimens, particularly when the number of organisms is small. |
| first_indexed | 2024-12-21T16:19:09Z |
| format | Article |
| id | doaj.art-5b6784d7042a4f68a58cd8a00666837b |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-21T16:19:09Z |
| publishDate | 2018-01-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-5b6784d7042a4f68a58cd8a00666837b2022-12-21T18:57:37ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452018-01-01521616310.4132/jptm.2017.06.1316732Liquid-Based Cytology of the Cerebrospinal Fluid in a Case of Cryptococcal MeningitisJiwoon ChoiSe Hoon Kim0 Department of Pathology, Yonsei University College of Medicine, Seoul, KoreaCryptococcus neoformans is the most common microorganism found in cerebrospinal fluid (CSF) cytology and causes life-threatening infections in immunocompromised hosts. Although its cytomorphologic features in conventional smear cytology have been well described, those in liquid-based cytology have rarely been. A 73-year-old woman with diffuse large B-cell lymphoma presented with mental confusion and a spiking fever. To rule out infectious conditions, CSF examination was performed. A cytology slide that was prepared using the ThinPrep method showed numerous spherical yeast-form organisms with diameters of 4–11 μm and thick capsules. Occasional asymmetrical, narrow-based budding but no true hyphae or pseudohyphae were observed. Gomori methenamine silver staining was positive. Cryptococcosis was confirmed in blood and CSF through the cryptococcal antigen test and culture. Liquid-based cytology allows for a clean background and additional slides for ancillary testing, facilitating the detection of microorganisms in CSF specimens, particularly when the number of organisms is small.http://www.jpatholtm.org/upload/pdf/jptm-2017-06-13.pdfCerebrospinal fluidLiquid-based cytology |
| spellingShingle | Jiwoon Choi Se Hoon Kim Liquid-Based Cytology of the Cerebrospinal Fluid in a Case of Cryptococcal Meningitis Journal of Pathology and Translational Medicine Cerebrospinal fluid Liquid-based cytology |
| title | Liquid-Based Cytology of the Cerebrospinal Fluid in a Case of Cryptococcal Meningitis |
| title_full | Liquid-Based Cytology of the Cerebrospinal Fluid in a Case of Cryptococcal Meningitis |
| title_fullStr | Liquid-Based Cytology of the Cerebrospinal Fluid in a Case of Cryptococcal Meningitis |
| title_full_unstemmed | Liquid-Based Cytology of the Cerebrospinal Fluid in a Case of Cryptococcal Meningitis |
| title_short | Liquid-Based Cytology of the Cerebrospinal Fluid in a Case of Cryptococcal Meningitis |
| title_sort | liquid based cytology of the cerebrospinal fluid in a case of cryptococcal meningitis |
| topic | Cerebrospinal fluid Liquid-based cytology |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2017-06-13.pdf |
| work_keys_str_mv | AT jiwoonchoi liquidbasedcytologyofthecerebrospinalfluidinacaseofcryptococcalmeningitis AT sehoonkim liquidbasedcytologyofthecerebrospinalfluidinacaseofcryptococcalmeningitis |