Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts
Obesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 receptors. In the search for new components for the trea...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1181948/full |
| _version_ | 1827907691082678272 |
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| author | Hangxiu Che Hangxiu Che Yaqun Wang Jinhui Lao Yixin Deng Chirui Xu Hanxiao Yin Zheng Tang Yonghong Huang Hong Xu |
| author_facet | Hangxiu Che Hangxiu Che Yaqun Wang Jinhui Lao Yixin Deng Chirui Xu Hanxiao Yin Zheng Tang Yonghong Huang Hong Xu |
| author_sort | Hangxiu Che |
| collection | DOAJ |
| description | Obesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 receptors. In the search for new components for the treatments of obesity, we and other researchers have found much evidence that natural plant extracts may be promising novel therapeutic approaches by modulating purinergic signalling. In this review, we summarize a critical role of purinergic signalling in modulating obesity-associated end-organ damage, such as overhigh appetite, myocardial ischemia, inflammation, atherosclerosis, non-alcoholic fatty liver disease (NAFLD), hepatic steatosis and renal inflammation. Moreover, we focus on the potential roles of several natural plant extracts, including quercetin, resveratrol/trans-resveratrol, caffeine, evodiamine and puerarin, in alleviating obesity-associated end-organ damage via purinergic signalling. We hope that the current knowledge of the potential roles of natural plant extracts in regulating purinergic signalling would provide new ideas for the treatment of obesity and obesity-associated end-organ damage. |
| first_indexed | 2024-03-13T01:11:40Z |
| format | Article |
| id | doaj.art-5b67b700046a4f969ae6b65c6ab3e13f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T01:11:40Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-5b67b700046a4f969ae6b65c6ab3e13f2023-07-05T17:42:50ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-07-011410.3389/fendo.2023.11819481181948Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extractsHangxiu Che0Hangxiu Che1Yaqun Wang2Jinhui Lao3Yixin Deng4Chirui Xu5Hanxiao Yin6Zheng Tang7Yonghong Huang8Hong Xu9Department of Physiology, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, ChinaJoint Program of Nanchang University and Queen Mary University of London, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Physiology, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Physiology, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, ChinaBasic Medicine, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, ChinaHuankui Academy, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, ChinaHuankui Academy, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, ChinaThe Second Clinical Medicine, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Pathophysiology, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Physiology, Jiangxi Medical College of Nanchang University, Nanchang, Jiangxi, ChinaObesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 receptors. In the search for new components for the treatments of obesity, we and other researchers have found much evidence that natural plant extracts may be promising novel therapeutic approaches by modulating purinergic signalling. In this review, we summarize a critical role of purinergic signalling in modulating obesity-associated end-organ damage, such as overhigh appetite, myocardial ischemia, inflammation, atherosclerosis, non-alcoholic fatty liver disease (NAFLD), hepatic steatosis and renal inflammation. Moreover, we focus on the potential roles of several natural plant extracts, including quercetin, resveratrol/trans-resveratrol, caffeine, evodiamine and puerarin, in alleviating obesity-associated end-organ damage via purinergic signalling. We hope that the current knowledge of the potential roles of natural plant extracts in regulating purinergic signalling would provide new ideas for the treatment of obesity and obesity-associated end-organ damage.https://www.frontiersin.org/articles/10.3389/fendo.2023.1181948/fullobesitypurinergic signallingATPP1 receptorP2 receptor |
| spellingShingle | Hangxiu Che Hangxiu Che Yaqun Wang Jinhui Lao Yixin Deng Chirui Xu Hanxiao Yin Zheng Tang Yonghong Huang Hong Xu Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts Frontiers in Endocrinology obesity purinergic signalling ATP P1 receptor P2 receptor |
| title | Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts |
| title_full | Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts |
| title_fullStr | Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts |
| title_full_unstemmed | Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts |
| title_short | Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts |
| title_sort | role of purinergic signalling in obesity associated end organ damage focus on the effects of natural plant extracts |
| topic | obesity purinergic signalling ATP P1 receptor P2 receptor |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1181948/full |
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