Cyclodextrin Complexed Lipid Nanoparticles of Irbesartan for Oral Applications: Design, Development, and In Vitro Characterization

Cyclodextrin Complexed Lipid Nanoparticles of Irbesartan for Oral Applications: Design, Development, and In Vitro Characterization

Irbesartan (IR) is an angiotensin II receptor antagonist drug with antihypertensive activity. IR bioavailability is limited due to poor solubility and first-pass metabolism. The current investigation aimed to design, develop, and characterize the cyclodextrin(s) (CD) complexed IR (IR-CD) loaded soli...

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Bibliographic Details
Main Authors: Narendar Dudhipala, Swetha Ettireddy, Ahmed Adel Ali Youssef, Goverdhan Puchchakayala
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
irbesartan
complexation
cyclodextrin
solid lipid nanoparticles
sustained release
Online Access:https://www.mdpi.com/1420-3049/26/24/7538

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