The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis
The secretory pathway is an intracellular highway for the vesicular transport of newly synthesized proteins that spans the endoplasmic reticulum (ER), Golgi, lysosomes and the cell surface. A variety of cargo receptors, chaperones, and quality control proteins maintain the smooth flow of cargo along...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1096899/full |
| _version_ | 1797950873257639936 |
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| author | Benjamin S. Roberts Prasanna Satpute-Krishnan |
| author_facet | Benjamin S. Roberts Prasanna Satpute-Krishnan |
| author_sort | Benjamin S. Roberts |
| collection | DOAJ |
| description | The secretory pathway is an intracellular highway for the vesicular transport of newly synthesized proteins that spans the endoplasmic reticulum (ER), Golgi, lysosomes and the cell surface. A variety of cargo receptors, chaperones, and quality control proteins maintain the smooth flow of cargo along this route. Among these is vesicular transport protein TMED9, which belongs to the p24/transmembrane emp24 domain (TMED) family of proteins, and is expressed across vertebrate species. The TMED family is comprised of structurally-related type I transmembrane proteins with a luminal N-terminal Golgi-dynamics domain, a luminal coiled-coil domain, a transmembrane domain and a short cytosolic C-terminal tail that binds COPI and COPII coat proteins. TMED9, like other members of the TMED family, was first identified as an abundant constituent of the COPI and COPII coated vesicles that mediate traffic between the ER and the Golgi. TMED9 is typically purified in hetero-oligomers together with TMED family members, suggesting that it may function as part of a complex. Recently, TMED family members have been discovered to play various roles in secretory pathway homeostasis including secreted protein processing, quality control and degradation of misfolded proteins, and post-Golgi trafficking. In particular, TMED9 has been implicated in autophagy, lysosomal sorting, viral replication and cancer, which we will discuss in this Mini-Review. |
| first_indexed | 2024-04-10T22:21:53Z |
| format | Article |
| id | doaj.art-5b68c906b7ac4b83ae4a5281b714ad2c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-10T22:21:53Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-5b68c906b7ac4b83ae4a5281b714ad2c2023-01-17T16:19:12ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-01-011010.3389/fcell.2022.10968991096899The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasisBenjamin S. RobertsPrasanna Satpute-KrishnanThe secretory pathway is an intracellular highway for the vesicular transport of newly synthesized proteins that spans the endoplasmic reticulum (ER), Golgi, lysosomes and the cell surface. A variety of cargo receptors, chaperones, and quality control proteins maintain the smooth flow of cargo along this route. Among these is vesicular transport protein TMED9, which belongs to the p24/transmembrane emp24 domain (TMED) family of proteins, and is expressed across vertebrate species. The TMED family is comprised of structurally-related type I transmembrane proteins with a luminal N-terminal Golgi-dynamics domain, a luminal coiled-coil domain, a transmembrane domain and a short cytosolic C-terminal tail that binds COPI and COPII coat proteins. TMED9, like other members of the TMED family, was first identified as an abundant constituent of the COPI and COPII coated vesicles that mediate traffic between the ER and the Golgi. TMED9 is typically purified in hetero-oligomers together with TMED family members, suggesting that it may function as part of a complex. Recently, TMED family members have been discovered to play various roles in secretory pathway homeostasis including secreted protein processing, quality control and degradation of misfolded proteins, and post-Golgi trafficking. In particular, TMED9 has been implicated in autophagy, lysosomal sorting, viral replication and cancer, which we will discuss in this Mini-Review.https://www.frontiersin.org/articles/10.3389/fcell.2022.1096899/fulltransmembrane emp24 domainp24 familycargo receptorautophagysecretory pathway homeostasisCOP Coatomer |
| spellingShingle | Benjamin S. Roberts Prasanna Satpute-Krishnan The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis Frontiers in Cell and Developmental Biology transmembrane emp24 domain p24 family cargo receptor autophagy secretory pathway homeostasis COP Coatomer |
| title | The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis |
| title_full | The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis |
| title_fullStr | The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis |
| title_full_unstemmed | The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis |
| title_short | The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis |
| title_sort | many hats of transmembrane emp24 domain protein tmed9 in secretory pathway homeostasis |
| topic | transmembrane emp24 domain p24 family cargo receptor autophagy secretory pathway homeostasis COP Coatomer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1096899/full |
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