Genetic Diversity and Low Therapeutic Impact of Variant-Specific Markers in HIV-1 Pol Proteins

Genetic Diversity and Low Therapeutic Impact of Variant-Specific Markers in HIV-1 Pol Proteins

The emergence and spread of new HIV-1 variants pose a challenge for the effectiveness of antiretrovirals (ARV) targeting Pol proteins. During viral evolution, non-synonymous mutations have fixed along the viral genome, leading to amino acid (aa) changes that can be variant-specific (V-markers). Thos...

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Bibliographic Details
Main Authors: Paloma Troyano-Hernáez, Roberto Reinosa, Africa Holguín
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Microbiology
Subjects:
HIV-1
Pol
protease
integrase
conservation
variants
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.866705/full

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