Transient elastography with controlled attenuation parameter versus two-dimensional shear wave elastography with attenuation imaging for the evaluation of hepatic steatosis and fibrosis in NAFLD
Purpose This study compared the controlled attenuation parameter (CAP) to attenuation imaging (ATI) in the diagnosis of steatosis and transient elastography (TE) to two-dimensional shear wave elastography (2D-SWE) for the diagnosis of fibrosis in a prospectively constructed nonalcoholic fatty liver...
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| Format: | Article |
| Language: | English |
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Korean Society of Ultrasound in Medicine
2023-07-01
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| Series: | Ultrasonography |
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| Online Access: | http://www.e-ultrasonography.org/upload/usg-22212.pdf |
| _version_ | 1797789142158934016 |
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| author | Jung Wook Seo Youe Ree Kim Jong Keon Jang So Yeon Kim Young Youn Cho Eun Sun Lee Dong Ho Lee |
| author_facet | Jung Wook Seo Youe Ree Kim Jong Keon Jang So Yeon Kim Young Youn Cho Eun Sun Lee Dong Ho Lee |
| author_sort | Jung Wook Seo |
| collection | DOAJ |
| description | Purpose This study compared the controlled attenuation parameter (CAP) to attenuation imaging (ATI) in the diagnosis of steatosis and transient elastography (TE) to two-dimensional shear wave elastography (2D-SWE) for the diagnosis of fibrosis in a prospectively constructed nonalcoholic fatty liver disease (NAFLD) patient cohort. Methods Participants who underwent TE with CAP were included from a previously constructed NAFLD cohort with multiparametric ultrasound data. The degree of hepatic steatosis and stage of liver fibrosis were assessed. Diagnostic performance was evaluated using the area under the receiver operating characteristic curve (AUROC) for the grades of steatosis (S1-3) and fibrosis (F0-F4). Results There were 105 participants. The distribution of hepatic steatosis grades (S0-S3) and liver fibrosis stages (F0-F4) was as follows: S0, n=34; S1, n=41; S2, n=22; S3, n=8; F0, n=63; F1, n=25; F2, n=5; F3, n=7; and F4, n=5. No significant difference was found between CAP and ATI in detecting ≥S1 (AUROC: 0.93 vs. 0.93, P=0.956) or ≥S2 (0.94 vs. 0.94, P=0.769). However, the AUROC of ATI in detecting ≥S3 was significantly higher than that of CAP (0.94 vs. 0.87, P=0.047). Regarding the detection of liver fibrosis, no significant difference was found between TE and 2D-SWE. The AUROCs of TE and 2D-SWE were as follows: ≥F1, 0.94 vs. 0.89 (P=0.107); ≥F2, 0.89 vs. 0.90 (P=0.644); ≥F3, 0.91 vs. 0.90 (P=0.703); and ≥F4, 0.88 vs. 0.92 (P=0.209). Conclusion 2D-SWE and TE showed comparable diagnostic performance in assessing liver fibrosis, and ATI provided significantly better performance in detecting ≥S3 steatosis than CAP. |
| first_indexed | 2024-03-13T01:46:32Z |
| format | Article |
| id | doaj.art-5b6927bcb4924de39876d4d9ff26e9b8 |
| institution | Directory Open Access Journal |
| issn | 2288-5943 |
| language | English |
| last_indexed | 2024-03-13T01:46:32Z |
| publishDate | 2023-07-01 |
| publisher | Korean Society of Ultrasound in Medicine |
| record_format | Article |
| series | Ultrasonography |
| spelling | doaj.art-5b6927bcb4924de39876d4d9ff26e9b82023-07-03T07:54:07ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59432023-07-0142342143110.14366/usg.222121665Transient elastography with controlled attenuation parameter versus two-dimensional shear wave elastography with attenuation imaging for the evaluation of hepatic steatosis and fibrosis in NAFLDJung Wook Seo0Youe Ree Kim1Jong Keon Jang2So Yeon Kim3Young Youn Cho4Eun Sun Lee5Dong Ho Lee6 Department of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea Department of Radiology, Wonkwang University Hospital, Wonkwang University College of Medicine, Iksan, Korea Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea Department of Radiology, Chung-Ang University Hospital, Seoul, Korea Department of Radiology, Seoul National University Hospital, Seoul, KoreaPurpose This study compared the controlled attenuation parameter (CAP) to attenuation imaging (ATI) in the diagnosis of steatosis and transient elastography (TE) to two-dimensional shear wave elastography (2D-SWE) for the diagnosis of fibrosis in a prospectively constructed nonalcoholic fatty liver disease (NAFLD) patient cohort. Methods Participants who underwent TE with CAP were included from a previously constructed NAFLD cohort with multiparametric ultrasound data. The degree of hepatic steatosis and stage of liver fibrosis were assessed. Diagnostic performance was evaluated using the area under the receiver operating characteristic curve (AUROC) for the grades of steatosis (S1-3) and fibrosis (F0-F4). Results There were 105 participants. The distribution of hepatic steatosis grades (S0-S3) and liver fibrosis stages (F0-F4) was as follows: S0, n=34; S1, n=41; S2, n=22; S3, n=8; F0, n=63; F1, n=25; F2, n=5; F3, n=7; and F4, n=5. No significant difference was found between CAP and ATI in detecting ≥S1 (AUROC: 0.93 vs. 0.93, P=0.956) or ≥S2 (0.94 vs. 0.94, P=0.769). However, the AUROC of ATI in detecting ≥S3 was significantly higher than that of CAP (0.94 vs. 0.87, P=0.047). Regarding the detection of liver fibrosis, no significant difference was found between TE and 2D-SWE. The AUROCs of TE and 2D-SWE were as follows: ≥F1, 0.94 vs. 0.89 (P=0.107); ≥F2, 0.89 vs. 0.90 (P=0.644); ≥F3, 0.91 vs. 0.90 (P=0.703); and ≥F4, 0.88 vs. 0.92 (P=0.209). Conclusion 2D-SWE and TE showed comparable diagnostic performance in assessing liver fibrosis, and ATI provided significantly better performance in detecting ≥S3 steatosis than CAP.http://www.e-ultrasonography.org/upload/usg-22212.pdfliver cirrhosisfatty liverelasticity imaging techniques |
| spellingShingle | Jung Wook Seo Youe Ree Kim Jong Keon Jang So Yeon Kim Young Youn Cho Eun Sun Lee Dong Ho Lee Transient elastography with controlled attenuation parameter versus two-dimensional shear wave elastography with attenuation imaging for the evaluation of hepatic steatosis and fibrosis in NAFLD Ultrasonography liver cirrhosis fatty liver elasticity imaging techniques |
| title | Transient elastography with controlled attenuation parameter versus two-dimensional shear wave elastography with attenuation imaging for the evaluation of hepatic steatosis and fibrosis in NAFLD |
| title_full | Transient elastography with controlled attenuation parameter versus two-dimensional shear wave elastography with attenuation imaging for the evaluation of hepatic steatosis and fibrosis in NAFLD |
| title_fullStr | Transient elastography with controlled attenuation parameter versus two-dimensional shear wave elastography with attenuation imaging for the evaluation of hepatic steatosis and fibrosis in NAFLD |
| title_full_unstemmed | Transient elastography with controlled attenuation parameter versus two-dimensional shear wave elastography with attenuation imaging for the evaluation of hepatic steatosis and fibrosis in NAFLD |
| title_short | Transient elastography with controlled attenuation parameter versus two-dimensional shear wave elastography with attenuation imaging for the evaluation of hepatic steatosis and fibrosis in NAFLD |
| title_sort | transient elastography with controlled attenuation parameter versus two dimensional shear wave elastography with attenuation imaging for the evaluation of hepatic steatosis and fibrosis in nafld |
| topic | liver cirrhosis fatty liver elasticity imaging techniques |
| url | http://www.e-ultrasonography.org/upload/usg-22212.pdf |
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