Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients
Electrophysiological methods could provide important information about the neurophysiological status in Parkinson's disease (PD). Objective: To investigate the prolonged auditory P300 latency in PD and its association with the disease clinical stage. Method: Clinical profiles of 44 patient...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2014-04-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000400296&lng=en&tlng=en |
| _version_ | 1818999907063693312 |
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| author | Marcia da Silva Lopes Ailton de Souza Melo Ana Caline Nóbrega |
| author_facet | Marcia da Silva Lopes Ailton de Souza Melo Ana Caline Nóbrega |
| author_sort | Marcia da Silva Lopes |
| collection | DOAJ |
| description | Electrophysiological methods could provide important information about the neurophysiological status in Parkinson's disease (PD). Objective: To investigate the prolonged auditory P300 latency in PD and its association with the disease clinical stage. Method: Clinical profiles of 44 patients were evaluated and those in initial and advanced stages of PD were identified. The frequency of altered latencies, median of latencies in each stage, and correlation between latencies and motor and non-motor clinical features were analyzed. Latencies were considered altered when they were more than two standard deviations from the mean of controls, per age group. Results: It was verified 10% of alterations in initial stages and 31% in advanced. There was correlation between latencies and non-motor clinical features. Subjects older than 65, in advanced stages, presented a significant increase of latencies. Conclusion: There was an association between PD severity and P300 prolonged latencies among subjects 65 years old or older. |
| first_indexed | 2024-12-20T22:24:52Z |
| format | Article |
| id | doaj.art-5b69841b358b47628669fdc722113fc7 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-20T22:24:52Z |
| publishDate | 2014-04-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-5b69841b358b47628669fdc722113fc72022-12-21T19:24:50ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272014-04-0172429630010.1590/0004-282X20140005S0004-282X2014000400296Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patientsMarcia da Silva LopesAilton de Souza MeloAna Caline NóbregaElectrophysiological methods could provide important information about the neurophysiological status in Parkinson's disease (PD). Objective: To investigate the prolonged auditory P300 latency in PD and its association with the disease clinical stage. Method: Clinical profiles of 44 patients were evaluated and those in initial and advanced stages of PD were identified. The frequency of altered latencies, median of latencies in each stage, and correlation between latencies and motor and non-motor clinical features were analyzed. Latencies were considered altered when they were more than two standard deviations from the mean of controls, per age group. Results: It was verified 10% of alterations in initial stages and 31% in advanced. There was correlation between latencies and non-motor clinical features. Subjects older than 65, in advanced stages, presented a significant increase of latencies. Conclusion: There was an association between PD severity and P300 prolonged latencies among subjects 65 years old or older.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000400296&lng=en&tlng=enP300doença de Parkinson idiopáticaenvelhecimentopotenciais evocados auditivos relacionados a eventos |
| spellingShingle | Marcia da Silva Lopes Ailton de Souza Melo Ana Caline Nóbrega Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients Arquivos de Neuro-Psiquiatria P300 doença de Parkinson idiopática envelhecimento potenciais evocados auditivos relacionados a eventos |
| title | Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients |
| title_full | Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients |
| title_fullStr | Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients |
| title_full_unstemmed | Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients |
| title_short | Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients |
| title_sort | delayed latencies of auditory evoked potential p300 are associated with the severity of parkinson s disease in older patients |
| topic | P300 doença de Parkinson idiopática envelhecimento potenciais evocados auditivos relacionados a eventos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000400296&lng=en&tlng=en |
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