Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics
Neuroinflammation is an important factor in the pathogenesis of neurodegenerative disesases. The following study aimed to clarify the effects of β-lactam antibiotics to the cholinergic system, on acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities, considering the structural differ...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
De Gruyter
2022-05-01
|
Series: | Türk Biyokimya Dergisi |
Subjects: | |
Online Access: | https://doi.org/10.1515/tjb-2021-0277 |
Summary: | Neuroinflammation is an important factor in the pathogenesis of neurodegenerative disesases. The following study aimed to clarify the effects of β-lactam antibiotics to the cholinergic system, on acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities, considering the structural differences of antibiotics, to evaluate the underlying mechanism of effects provided by protein-antibiotic interactions, and to clarify possible effects of the antibiotics on the aggregation of Aβ-peptides. |
---|---|
ISSN: | 1303-829X |