Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics
Neuroinflammation is an important factor in the pathogenesis of neurodegenerative disesases. The following study aimed to clarify the effects of β-lactam antibiotics to the cholinergic system, on acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities, considering the structural differ...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-05-01
|
| Series: | Türk Biyokimya Dergisi |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tjb-2021-0277 |
| _version_ | 1828295346993758208 |
|---|---|
| author | Özer Eda Özturan Mirza Hasan Cenk Tan Oya Ünsal Türkoğlu Suna |
| author_facet | Özer Eda Özturan Mirza Hasan Cenk Tan Oya Ünsal Türkoğlu Suna |
| author_sort | Özer Eda Özturan |
| collection | DOAJ |
| description | Neuroinflammation is an important factor in the pathogenesis of neurodegenerative disesases. The following study aimed to clarify the effects of β-lactam antibiotics to the cholinergic system, on acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities, considering the structural differences of antibiotics, to evaluate the underlying mechanism of effects provided by protein-antibiotic interactions, and to clarify possible effects of the antibiotics on the aggregation of Aβ-peptides. |
| first_indexed | 2024-04-13T11:52:28Z |
| format | Article |
| id | doaj.art-5b6db14cf05e4043ac1c228757c3bf49 |
| institution | Directory Open Access Journal |
| issn | 1303-829X |
| language | English |
| last_indexed | 2024-04-13T11:52:28Z |
| publishDate | 2022-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Türk Biyokimya Dergisi |
| spelling | doaj.art-5b6db14cf05e4043ac1c228757c3bf492022-12-22T02:47:59ZengDe GruyterTürk Biyokimya Dergisi1303-829X2022-05-0147335936910.1515/tjb-2021-0277Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibioticsÖzer Eda Özturan0Mirza Hasan Cenk1Tan Oya Ünsal2Türkoğlu Suna3School of Medicine, Department of Medical Biochemistry, Baskent University, Ankara, TurkeySchool of Medicine, Department of Medical Microbiology, Baskent University, Ankara, TurkeyFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Hacettepe University, Ankara, TurkeySchool of Medicine, Department of Medical Biochemistry, Baskent University, Ankara, TurkeyNeuroinflammation is an important factor in the pathogenesis of neurodegenerative disesases. The following study aimed to clarify the effects of β-lactam antibiotics to the cholinergic system, on acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities, considering the structural differences of antibiotics, to evaluate the underlying mechanism of effects provided by protein-antibiotic interactions, and to clarify possible effects of the antibiotics on the aggregation of Aβ-peptides.https://doi.org/10.1515/tjb-2021-0277β-lactam antibioticsacetylcholinesteraseamyloid beta peptidesbutyrylcholinesterasemolecular dockingβ-laktam antibiyotikamiloid beta peptitasetilkolinesterazbütirilkolinesterazmoleküler modelleme |
| spellingShingle | Özer Eda Özturan Mirza Hasan Cenk Tan Oya Ünsal Türkoğlu Suna Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics Türk Biyokimya Dergisi β-lactam antibiotics acetylcholinesterase amyloid beta peptides butyrylcholinesterase molecular docking β-laktam antibiyotik amiloid beta peptit asetilkolinesteraz bütirilkolinesteraz moleküler modelleme |
| title | Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics |
| title_full | Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics |
| title_fullStr | Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics |
| title_full_unstemmed | Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics |
| title_short | Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics |
| title_sort | investigation of anti cholinesterase and anti amyloidogenic activities of β lactam antibiotics |
| topic | β-lactam antibiotics acetylcholinesterase amyloid beta peptides butyrylcholinesterase molecular docking β-laktam antibiyotik amiloid beta peptit asetilkolinesteraz bütirilkolinesteraz moleküler modelleme |
| url | https://doi.org/10.1515/tjb-2021-0277 |
| work_keys_str_mv | AT ozeredaozturan investigationofanticholinesteraseandantiamyloidogenicactivitiesofblactamantibiotics AT mirzahasancenk investigationofanticholinesteraseandantiamyloidogenicactivitiesofblactamantibiotics AT tanoyaunsal investigationofanticholinesteraseandantiamyloidogenicactivitiesofblactamantibiotics AT turkoglusuna investigationofanticholinesteraseandantiamyloidogenicactivitiesofblactamantibiotics |