Extracellular Hsp90α Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer

Extracellular Hsp90α Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer

Early detection and discovery of new therapeutic targets are urgently needed to improve the breast cancer treatment outcome. Here we conducted an official clinical trial with cross-validation to corroborate human plasma Hsp90α as a novel breast cancer biomarker. Importantly, similar results were not...

Full description

Bibliographic Details
Main Authors:	Qiaoyun Hou, Shuohua Chen, Qi An, Boya Li, Yan Fu, Yongzhang Luo
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	International Journal of Molecular Sciences
Subjects:	plasma Hsp90α tumor biomarker breast cancer lymph node metastasis extracellular Hsp90α lymphangiogenesis
Online Access:	https://www.mdpi.com/1422-0067/22/14/7747

Similar Items

Cytosolic Hsp90 Isoform-Specific Functions and Clinical Significance
by: Samarpan Maiti, et al.
Published: (2022-08-01)

Analysis of the prognostic, diagnostic and immunological role of HSP90α in malignant tumors
by: Zhimin Yuan, et al.
Published: (2022-09-01)

The Distinct Assignments for Hsp90α and Hsp90β: More Than Skin Deep
by: Cheng Chang, et al.
Published: (2023-01-01)

Decreased Expression of Heat Shock Protein HSP90α after Exposure to Doxorubicin in Breast Cancer Cell Lines (MCF-7 and MDA-MB-231)
by: Fereshte Jokar, et al.
Published: (2017-02-01)

Metformin Inhibits Tumor Metastasis through Suppressing Hsp90α Secretion in an AMPKα1-PKCγ Dependent Manner
by: Yuanchao Gong, et al.
Published: (2020-01-01)

Kajian Heat Shock Protein 90 (HSP90) dalam Pencarian Kandidat Penghambatnya melalui Ekplorasi Bahan Alam Indonesia
by: Rehmadanta Sitepu
Published: (2019-03-01)

Extracellular Heat Shock Protein-90 (eHsp90): Everything You Need to Know
by: Daniel Jay, et al.
Published: (2022-06-01)

Aberrant HSP90 Expression in Lymphocytes and HSP90 Response to Anti-PD-1 Therapy in Lymphoma Patients
by: Zarema Albakova, et al.
Published: (2022-04-01)

Spermatogenesis arrest caused by conditional deletion of Hsp90α in adult mice
by: Chiaki Kajiwara, et al.
Published: (2012-08-01)

Extracellular HSP90α Induces MyD88-IRAK Complex-Associated IKKα/β−NF-κB/IRF3 and JAK2/TYK2−STAT-3 Signaling in Macrophages for Tumor-Promoting M2-Polarization
by: Chi-Shuan Fan, et al.
Published: (2022-01-01)

Role of Heat Shock Proteins (HSP70 and HSP90) in Viral Infection
by: Anna Lubkowska, et al.
Published: (2021-08-01)

The active components of Smilax china L. against cancer by interfering with the interactions among associated proteins
by: Song-Tao Wu, et al.
Published: (2023-07-01)

Extracellular Hsp90α Supports the ePKM2-GRP78-AKT Axis to Promote Tumor Metastasis
by: Shaosen Zhang, et al.
Published: (2022-06-01)

Inhibition of Embryonic HSP 90 Function Promotes Variation of Cold Tolerance in Zebrafish
by: Bingshe Han, et al.
Published: (2020-12-01)

Fluorescence Masking Based Multifunctional Quantum Dots’ Assay for HSP90α Interactions Detection
by: Anusha Kishore, et al.
Published: (2023-02-01)

Upregulation of TGF-β-induced HSP27 by HSP90 inhibitors in osteoblasts
by: Gen Kuroyanagi, et al.
Published: (2022-05-01)

Inhibition of HSP90 in Driver Oncogene-Defined Lung Adenocarcinoma Cell Lines: Key Proteins Underpinning Therapeutic Efficacy
by: Ángela Marrugal, et al.
Published: (2023-09-01)

Plasma Heat Shock Protein 90alpha as a Biomarker for the Diagnosis of Liver Cancer: An Official, Large-scale, and Multicenter Clinical Trial
by: Yan Fu, et al.
Published: (2017-10-01)

Evaluation of the diagnostic and prognostic values of serum HSP90α in sepsis patients: a retrospective study
by: Fuxing Li, et al.
Published: (2022-03-01)

Role of Extracellular Vesicles on Cancer Lymphangiogenesis and Lymph Node Metastasis
by: Linlin Wang, et al.
Published: (2021-09-01)

High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors
by: Jason Davenport, et al.
Published: (2014-02-01)

In silico genomic and proteomic analyses of three heat shock proteins (HSP70, HSP90-α, and HSP90-β) in even-toed ungulates
by: Sayed Haidar Abbas Raza, et al.
Published: (2021-09-01)

Predictive Modeling of MAFLD Based on Hsp90α and the Therapeutic Application of Teprenone in a Diet-Induced Mouse Model
by: Yuan Xie, et al.
Published: (2021-09-01)

Differential Expression of HSP90β in MDA-MB-231 and MCF-7 Cell Lines after Treatment with Doxorubicin
by: Fereshte Jokar, et al.
Published: (2019-03-01)

α-Solanine induces ferroptosis in nasopharyngeal carcinoma via targeting HSP90α/p53 axis
by: Xuehui Cui, et al.
Published: (2023-05-01)

The Chaperone System in Tumors of the Vocal Cords: Quantity and Distribution Changes of Hsp10, Hsp27, Hsp60, and Hsp90 during Carcinogenesis
by: Alessandro Pitruzzella, et al.
Published: (2024-01-01)

HSP90α Mediates Sorafenib Resistance in Human Hepatocellular Carcinoma by Necroptosis Inhibition under Hypoxia
by: Yan Liao, et al.
Published: (2021-01-01)

HSP90 facilitates stemness and enhances glycolysis in glioma cells
by: Xun Kang, et al.
Published: (2022-11-01)

Evaluation of HSP70 deficiency in the inflammatory response in vivo and in vitro: The impact of HSP90 expression, glucocorticoid release, and glutamine administration
by: Ioanna Plati, et al.
Published: (2022-08-01)

The Role of HSP90 in Preserving the Integrity of Genomes Against Transposons Is Evolutionarily Conserved
by: Valeria Specchia, et al.
Published: (2021-05-01)

Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance
by: Dea Shahinas, et al.
Published: (2013-02-01)

Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment
by: Yong Li, et al.
Published: (2012-06-01)

Targeting extracellular Hsp90: A unique frontier against cancer
by: Rebecca A. Sager, et al.
Published: (2022-08-01)

Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration
by: Sarmistha Mitra, et al.
Published: (2022-11-01)

HSP90 Inhibition and Modulation of the Proteome: Therapeutical Implications for Idiopathic Pulmonary Fibrosis (IPF)
by: Ruben Manuel Luciano Colunga Biancatelli, et al.
Published: (2020-07-01)

HSP90 Interacts with the Fibronectin N-terminal Domains and Increases Matrix Formation
by: Abir Chakraborty, et al.
Published: (2020-01-01)

The Chaperone System in Salivary Glands: Hsp90 Prospects for Differential Diagnosis and Treatment of Malignant Tumors
by: Charbel A. Basset, et al.
Published: (2022-08-01)

Regulation of Protein Transport Pathways by the Cytosolic Hsp90s
by: Anna G. Mankovich, et al.
Published: (2022-08-01)

Expression Analysis of Molecular Chaperones Hsp70 and Hsp90 on Development and Metabolism of Different Organs and Testis in Cattle (Cattle–yak and Yak)
by: Yan Cui, et al.
Published: (2022-11-01)

Hsp70 and Hsp90 Elaborately Regulate RNAi Efficiency in <i>Plutella xylostella</i>
by: Sujie Lin, et al.
Published: (2023-11-01)