Efficacy of Tranexamic Acid in Reducing Blood Loss in Cesarean Section: A Comparative Study.
Introduction: Obstetric hemorrhage is one of the major causes of maternal morbidity and mortality. Blood loss during cesarean section is almost twice than that in vaginal delivery. The aim of this study was to evaluate the efficacy of tranexamic acid to reduce blood loss in cesarean section and its...
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| Format: | Article |
| Language: | English |
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Lumbini Medical College
2019-12-01
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| Series: | Journal of Lumbini Medical College |
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| Online Access: | https://www.jlmc.edu.np/index.php/JLMC/article/view/292 |
| _version_ | 1818368828451586048 |
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| author | Sarita Acharya Seoji Mishra |
| author_facet | Sarita Acharya Seoji Mishra |
| author_sort | Sarita Acharya |
| collection | DOAJ |
| description | Introduction: Obstetric hemorrhage is one of the major causes of maternal morbidity and mortality. Blood loss during cesarean section is almost twice than that in vaginal delivery. The aim of this study was to evaluate the efficacy of tranexamic acid to reduce blood loss in cesarean section and its side effects. Methods: A comparative study was done in 100 women undergoing cesarean section between December 2015 to January 2017. The study group of 50 women received one gram intravenous tranexamic acid and the control group of 50 women did not receive tranexamic acid. Primary outcome measure was blood loss during cesarean section. Secondary outcome measures were drop in post-operative hemoglobin and hematocrit, change in pulse rate and blood pressure, need of additional uterotonics, auxiliary procedures to stop bleeding, blood transfusion rate and maternal and neonatal side effects of the drug. Results: Mean intraoperative blood loss in the study group was 443.62± 86.73ml; and in control group, 667.40±131.01ml (p<0.001). Mean postoperative drop in hemoglobin (g/dl) in the two groups were 0.82±0.27 and 1.86±0.64 respectively (p<0.001). Mean postoperative drop in hematocrit in the two groups were 2.60±0.91 and 5.49±1.97 respectively (p<0.001). Fourteen patients in the control group required additional uterotonics while none in the study group (p<0.001). There was no significant difference in the transfusion requirement (p=0.079). None of the mothers and the newborns had major side effects of drug. Conclusion: Tranexamic acid is a safe and effective drug to reduce blood loss in cesarean section. |
| first_indexed | 2024-12-13T23:14:09Z |
| format | Article |
| id | doaj.art-5b7144d210a848e39971f27ce6c1435d |
| institution | Directory Open Access Journal |
| issn | 2392-4632 2542-2618 |
| language | English |
| last_indexed | 2024-12-13T23:14:09Z |
| publishDate | 2019-12-01 |
| publisher | Lumbini Medical College |
| record_format | Article |
| series | Journal of Lumbini Medical College |
| spelling | doaj.art-5b7144d210a848e39971f27ce6c1435d2022-12-21T23:27:59ZengLumbini Medical CollegeJournal of Lumbini Medical College2392-46322542-26182019-12-017210.22502/jlmc.v7i2.292Efficacy of Tranexamic Acid in Reducing Blood Loss in Cesarean Section: A Comparative Study.Sarita Acharya0Seoji Mishra1Universal College of Medical Sciences, Bhairahawa, NepalUniversal College of Medical Sciences, Bhairahawa, NepalIntroduction: Obstetric hemorrhage is one of the major causes of maternal morbidity and mortality. Blood loss during cesarean section is almost twice than that in vaginal delivery. The aim of this study was to evaluate the efficacy of tranexamic acid to reduce blood loss in cesarean section and its side effects. Methods: A comparative study was done in 100 women undergoing cesarean section between December 2015 to January 2017. The study group of 50 women received one gram intravenous tranexamic acid and the control group of 50 women did not receive tranexamic acid. Primary outcome measure was blood loss during cesarean section. Secondary outcome measures were drop in post-operative hemoglobin and hematocrit, change in pulse rate and blood pressure, need of additional uterotonics, auxiliary procedures to stop bleeding, blood transfusion rate and maternal and neonatal side effects of the drug. Results: Mean intraoperative blood loss in the study group was 443.62± 86.73ml; and in control group, 667.40±131.01ml (p<0.001). Mean postoperative drop in hemoglobin (g/dl) in the two groups were 0.82±0.27 and 1.86±0.64 respectively (p<0.001). Mean postoperative drop in hematocrit in the two groups were 2.60±0.91 and 5.49±1.97 respectively (p<0.001). Fourteen patients in the control group required additional uterotonics while none in the study group (p<0.001). There was no significant difference in the transfusion requirement (p=0.079). None of the mothers and the newborns had major side effects of drug. Conclusion: Tranexamic acid is a safe and effective drug to reduce blood loss in cesarean section.https://www.jlmc.edu.np/index.php/JLMC/article/view/292Blood lossCesarean sectionTranexamic acid |
| spellingShingle | Sarita Acharya Seoji Mishra Efficacy of Tranexamic Acid in Reducing Blood Loss in Cesarean Section: A Comparative Study. Journal of Lumbini Medical College Blood loss Cesarean section Tranexamic acid |
| title | Efficacy of Tranexamic Acid in Reducing Blood Loss in Cesarean Section: A Comparative Study. |
| title_full | Efficacy of Tranexamic Acid in Reducing Blood Loss in Cesarean Section: A Comparative Study. |
| title_fullStr | Efficacy of Tranexamic Acid in Reducing Blood Loss in Cesarean Section: A Comparative Study. |
| title_full_unstemmed | Efficacy of Tranexamic Acid in Reducing Blood Loss in Cesarean Section: A Comparative Study. |
| title_short | Efficacy of Tranexamic Acid in Reducing Blood Loss in Cesarean Section: A Comparative Study. |
| title_sort | efficacy of tranexamic acid in reducing blood loss in cesarean section a comparative study |
| topic | Blood loss Cesarean section Tranexamic acid |
| url | https://www.jlmc.edu.np/index.php/JLMC/article/view/292 |
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