The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity
Cyanidin-3-glucoside (C3G) is a well-known natural anthocyanin and possesses antioxidant and anti-inflammatory properties. The catabolism of C3G in the gastrointestinal tract could produce bioactive phenolic metabolites, such as protocatechuic acid, phloroglucinaldehyde, vanillic acid, and ferulic a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/10/479 |
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| author | Jijun Tan Yanli Li De-Xing Hou Shusong Wu |
| author_facet | Jijun Tan Yanli Li De-Xing Hou Shusong Wu |
| author_sort | Jijun Tan |
| collection | DOAJ |
| description | Cyanidin-3-glucoside (C3G) is a well-known natural anthocyanin and possesses antioxidant and anti-inflammatory properties. The catabolism of C3G in the gastrointestinal tract could produce bioactive phenolic metabolites, such as protocatechuic acid, phloroglucinaldehyde, vanillic acid, and ferulic acid, which enhance C3G bioavailability and contribute to both mucosal barrier and microbiota. To get an overview of the function and mechanisms of C3G and its phenolic metabolites, we review the accumulated data of the absorption and catabolism of C3G in the gastrointestine, and attempt to give crosstalk between the phenolic metabolites, gut microbiota, and mucosal innate immune signaling pathways. |
| first_indexed | 2024-03-12T06:10:38Z |
| format | Article |
| id | doaj.art-5b7304128e924c83bf73d7b650052bb6 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T06:10:38Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-5b7304128e924c83bf73d7b650052bb62023-09-03T03:04:33ZengMDPI AGAntioxidants2076-39212019-10-0181047910.3390/antiox8100479antiox8100479The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal IntegrityJijun Tan0Yanli Li1De-Xing Hou2Shusong Wu3Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaThe United Graduate School of Agricultural Sciences, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, JapanHunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCyanidin-3-glucoside (C3G) is a well-known natural anthocyanin and possesses antioxidant and anti-inflammatory properties. The catabolism of C3G in the gastrointestinal tract could produce bioactive phenolic metabolites, such as protocatechuic acid, phloroglucinaldehyde, vanillic acid, and ferulic acid, which enhance C3G bioavailability and contribute to both mucosal barrier and microbiota. To get an overview of the function and mechanisms of C3G and its phenolic metabolites, we review the accumulated data of the absorption and catabolism of C3G in the gastrointestine, and attempt to give crosstalk between the phenolic metabolites, gut microbiota, and mucosal innate immune signaling pathways.https://www.mdpi.com/2076-3921/8/10/479cyanidin-3-glucosidephenolic metabolitesgut microbiotasignaling pathwaysintestinal injury |
| spellingShingle | Jijun Tan Yanli Li De-Xing Hou Shusong Wu The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity Antioxidants cyanidin-3-glucoside phenolic metabolites gut microbiota signaling pathways intestinal injury |
| title | The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity |
| title_full | The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity |
| title_fullStr | The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity |
| title_full_unstemmed | The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity |
| title_short | The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity |
| title_sort | effects and mechanisms of cyanidin 3 glucoside and its phenolic metabolites in maintaining intestinal integrity |
| topic | cyanidin-3-glucoside phenolic metabolites gut microbiota signaling pathways intestinal injury |
| url | https://www.mdpi.com/2076-3921/8/10/479 |
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