Fluorine‐18‐fluorodeoxyglucose‐positron emission tomography evaluation in metastatic bone lesions in lung cancer: Possible prediction of pain and skeletal‐related events
Background Fluorine‐18‐fluorodeoxyglucose‐positron emission tomography (FDG‐PET) uptake in primary lesions has been well studied, but little information is available about metastatic bone lesions in patients with lung cancer. The present study was performed to evaluate the relationships between meta...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-04-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.13041 |
| _version_ | 1797845468345008128 |
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| author | Daisuke Gomi Toshirou Fukushima Takashi Kobayashi Nodoka Sekiguchi Tomonobu Koizumi Kazuhiko Oguchi |
| author_facet | Daisuke Gomi Toshirou Fukushima Takashi Kobayashi Nodoka Sekiguchi Tomonobu Koizumi Kazuhiko Oguchi |
| author_sort | Daisuke Gomi |
| collection | DOAJ |
| description | Background Fluorine‐18‐fluorodeoxyglucose‐positron emission tomography (FDG‐PET) uptake in primary lesions has been well studied, but little information is available about metastatic bone lesions in patients with lung cancer. The present study was performed to evaluate the relationships between metastatic bone FDG uptake and clinical parameters in patients with lung cancer. Methods FDG uptake was evaluated as the maximum standardized uptake (SUVmax) value of each targeted bone lesion, and the bone to primary lesion ratio of SUVmax (B/P ratio) was calculated. Forty‐nine patients (27 men and 22 women) with a diagnosis of lung cancer (small cell lung cancer [SCLC], n = 7; non‐small cell lung cancer [NSCLC], n = 42) with bone metastasis, and a total of 185 bone metastatic lesions were evaluated. Results The SUVmax in bone and the B/P ratio were significantly higher in patients with pain and subsequent development of skeletal‐related events than in those without pain or skeletal‐related events, respectively. In addition, the SUVmax in metastatic bone lesions and the B/P ratio in SCLC were significantly lower than those in NSCLC, despite similar FDG uptake in the primary tumor. Conclusion Our findings suggest that FDG‐PET evaluation in metastatic bone lesions could be useful to predict initial pain and subsequent clinical outcomes of local bone status in initially diagnosed lung cancer patients with bone metastasis. In addition, our results suggest that there could be histological differences in the biological activity of bone metastatic lesions in lung cancer, especially between SCLC and NSCLC. |
| first_indexed | 2024-04-09T17:39:31Z |
| format | Article |
| id | doaj.art-5b7377f0c1ba49c98137e130b6cded52 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-09T17:39:31Z |
| publishDate | 2019-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-5b7377f0c1ba49c98137e130b6cded522023-04-17T06:34:28ZengWileyThoracic Cancer1759-77061759-77142019-04-0110498098710.1111/1759-7714.13041Fluorine‐18‐fluorodeoxyglucose‐positron emission tomography evaluation in metastatic bone lesions in lung cancer: Possible prediction of pain and skeletal‐related eventsDaisuke Gomi0Toshirou Fukushima1Takashi Kobayashi2Nodoka Sekiguchi3Tomonobu Koizumi4Kazuhiko Oguchi5Department of Comprehensive Cancer Therapy Shinshu University School of Medicine Matsumoto JapanDepartment of Comprehensive Cancer Therapy Shinshu University School of Medicine Matsumoto JapanDepartment of Comprehensive Cancer Therapy Shinshu University School of Medicine Matsumoto JapanDepartment of Comprehensive Cancer Therapy Shinshu University School of Medicine Matsumoto JapanDepartment of Comprehensive Cancer Therapy Shinshu University School of Medicine Matsumoto JapanPositron Imaging Center Aizawa Hospital Matsumoto JapanBackground Fluorine‐18‐fluorodeoxyglucose‐positron emission tomography (FDG‐PET) uptake in primary lesions has been well studied, but little information is available about metastatic bone lesions in patients with lung cancer. The present study was performed to evaluate the relationships between metastatic bone FDG uptake and clinical parameters in patients with lung cancer. Methods FDG uptake was evaluated as the maximum standardized uptake (SUVmax) value of each targeted bone lesion, and the bone to primary lesion ratio of SUVmax (B/P ratio) was calculated. Forty‐nine patients (27 men and 22 women) with a diagnosis of lung cancer (small cell lung cancer [SCLC], n = 7; non‐small cell lung cancer [NSCLC], n = 42) with bone metastasis, and a total of 185 bone metastatic lesions were evaluated. Results The SUVmax in bone and the B/P ratio were significantly higher in patients with pain and subsequent development of skeletal‐related events than in those without pain or skeletal‐related events, respectively. In addition, the SUVmax in metastatic bone lesions and the B/P ratio in SCLC were significantly lower than those in NSCLC, despite similar FDG uptake in the primary tumor. Conclusion Our findings suggest that FDG‐PET evaluation in metastatic bone lesions could be useful to predict initial pain and subsequent clinical outcomes of local bone status in initially diagnosed lung cancer patients with bone metastasis. In addition, our results suggest that there could be histological differences in the biological activity of bone metastatic lesions in lung cancer, especially between SCLC and NSCLC.https://doi.org/10.1111/1759-7714.13041Bone metastasisFDGglucose activitysmall cell lung cancerSUVmax |
| spellingShingle | Daisuke Gomi Toshirou Fukushima Takashi Kobayashi Nodoka Sekiguchi Tomonobu Koizumi Kazuhiko Oguchi Fluorine‐18‐fluorodeoxyglucose‐positron emission tomography evaluation in metastatic bone lesions in lung cancer: Possible prediction of pain and skeletal‐related events Thoracic Cancer Bone metastasis FDG glucose activity small cell lung cancer SUVmax |
| title | Fluorine‐18‐fluorodeoxyglucose‐positron emission tomography evaluation in metastatic bone lesions in lung cancer: Possible prediction of pain and skeletal‐related events |
| title_full | Fluorine‐18‐fluorodeoxyglucose‐positron emission tomography evaluation in metastatic bone lesions in lung cancer: Possible prediction of pain and skeletal‐related events |
| title_fullStr | Fluorine‐18‐fluorodeoxyglucose‐positron emission tomography evaluation in metastatic bone lesions in lung cancer: Possible prediction of pain and skeletal‐related events |
| title_full_unstemmed | Fluorine‐18‐fluorodeoxyglucose‐positron emission tomography evaluation in metastatic bone lesions in lung cancer: Possible prediction of pain and skeletal‐related events |
| title_short | Fluorine‐18‐fluorodeoxyglucose‐positron emission tomography evaluation in metastatic bone lesions in lung cancer: Possible prediction of pain and skeletal‐related events |
| title_sort | fluorine 18 fluorodeoxyglucose positron emission tomography evaluation in metastatic bone lesions in lung cancer possible prediction of pain and skeletal related events |
| topic | Bone metastasis FDG glucose activity small cell lung cancer SUVmax |
| url | https://doi.org/10.1111/1759-7714.13041 |
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