Biodiversity of Russian Local Sheep Breeds Based on Pattern of Runs of Homozygosity
Russian sheep breeds traditionally raised in specific environments are valuable parts of sociocultural heritage and economic component of the regions. However, the import of commercial breeds negatively influences the population sizes of local sheep populations and might lead to biodiversity loss. E...
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MDPI AG
2021-08-01
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| Series: | Diversity |
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| Online Access: | https://www.mdpi.com/1424-2818/13/8/360 |
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| author | Tatiana Deniskova Arsen Dotsev Marina Selionova Gottfried Brem Natalia Zinovieva |
| author_facet | Tatiana Deniskova Arsen Dotsev Marina Selionova Gottfried Brem Natalia Zinovieva |
| author_sort | Tatiana Deniskova |
| collection | DOAJ |
| description | Russian sheep breeds traditionally raised in specific environments are valuable parts of sociocultural heritage and economic component of the regions. However, the import of commercial breeds negatively influences the population sizes of local sheep populations and might lead to biodiversity loss. Estimation of the runs of homozygosity (ROH) in local sheep genomes is an informative tool to address their current genetic state. In this work, we aimed to address the ROH distribution and to estimate genome inbreeding based on SNP data to evaluate genetic diversity in Russian local sheep breeds. Materials for this study included SNP-genotypes from twenty-seven Russian local sheep breeds which were generated using the Illumina OvineSNP50 BeadChip (<i>n</i> = 391) or the Illumina Ovine Infinium HD BeadChip (<i>n</i> = 315). A consecutive runs method was used to calculate ROH which were estimated for each animal and then categorized in the ROH length classes. The ROH were found in all breeds. The mean ROH length varied from 86 to 280 Mb, while the ROH number ranged from 37 to 123. The genomic inbreeding coefficient varied from 0.033 to 0.106. Our findings provide evidence of low to moderate genomic inbreeding in major local sheep populations. |
| first_indexed | 2024-03-10T08:52:34Z |
| format | Article |
| id | doaj.art-5b74618de2bb431ab7dbeb9ef72feb21 |
| institution | Directory Open Access Journal |
| issn | 1424-2818 |
| language | English |
| last_indexed | 2024-03-10T08:52:34Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diversity |
| spelling | doaj.art-5b74618de2bb431ab7dbeb9ef72feb212023-11-22T07:22:01ZengMDPI AGDiversity1424-28182021-08-0113836010.3390/d13080360Biodiversity of Russian Local Sheep Breeds Based on Pattern of Runs of HomozygosityTatiana Deniskova0Arsen Dotsev1Marina Selionova2Gottfried Brem3Natalia Zinovieva4L.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, Podolsk Municipal District, Moscow Region, 142132 Podolsk, RussiaL.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, Podolsk Municipal District, Moscow Region, 142132 Podolsk, RussiaRussian State Agrarian University—Moscow Timiryazev Agricultural Academy, 127550 Moscow, RussiaL.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, Podolsk Municipal District, Moscow Region, 142132 Podolsk, RussiaL.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, Podolsk Municipal District, Moscow Region, 142132 Podolsk, RussiaRussian sheep breeds traditionally raised in specific environments are valuable parts of sociocultural heritage and economic component of the regions. However, the import of commercial breeds negatively influences the population sizes of local sheep populations and might lead to biodiversity loss. Estimation of the runs of homozygosity (ROH) in local sheep genomes is an informative tool to address their current genetic state. In this work, we aimed to address the ROH distribution and to estimate genome inbreeding based on SNP data to evaluate genetic diversity in Russian local sheep breeds. Materials for this study included SNP-genotypes from twenty-seven Russian local sheep breeds which were generated using the Illumina OvineSNP50 BeadChip (<i>n</i> = 391) or the Illumina Ovine Infinium HD BeadChip (<i>n</i> = 315). A consecutive runs method was used to calculate ROH which were estimated for each animal and then categorized in the ROH length classes. The ROH were found in all breeds. The mean ROH length varied from 86 to 280 Mb, while the ROH number ranged from 37 to 123. The genomic inbreeding coefficient varied from 0.033 to 0.106. Our findings provide evidence of low to moderate genomic inbreeding in major local sheep populations.https://www.mdpi.com/1424-2818/13/8/360sheepsingle nucleotide polymorphismsruns of homozygositygenetic diversitygenomic inbreeding |
| spellingShingle | Tatiana Deniskova Arsen Dotsev Marina Selionova Gottfried Brem Natalia Zinovieva Biodiversity of Russian Local Sheep Breeds Based on Pattern of Runs of Homozygosity Diversity sheep single nucleotide polymorphisms runs of homozygosity genetic diversity genomic inbreeding |
| title | Biodiversity of Russian Local Sheep Breeds Based on Pattern of Runs of Homozygosity |
| title_full | Biodiversity of Russian Local Sheep Breeds Based on Pattern of Runs of Homozygosity |
| title_fullStr | Biodiversity of Russian Local Sheep Breeds Based on Pattern of Runs of Homozygosity |
| title_full_unstemmed | Biodiversity of Russian Local Sheep Breeds Based on Pattern of Runs of Homozygosity |
| title_short | Biodiversity of Russian Local Sheep Breeds Based on Pattern of Runs of Homozygosity |
| title_sort | biodiversity of russian local sheep breeds based on pattern of runs of homozygosity |
| topic | sheep single nucleotide polymorphisms runs of homozygosity genetic diversity genomic inbreeding |
| url | https://www.mdpi.com/1424-2818/13/8/360 |
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