Assessment of genetically modified maize MON 87427 × MON 89034 × MIR162 × NK603 and subcombinations, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2016‐131)
Abstract Maize MON 87427 × MON 89034 × MIR162 × NK603 (four‐event stack maize) was produced by conventional crossing to combine four single events: MON 87427, MON 89034, MIR162 and NK603. The GMO Panel previously assessed the four single maize events and four of the subcombinations did not identify...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-07-01
|
| Series: | EFSA Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.2903/j.efsa.2019.5734 |
| _version_ | 1819130434333704192 |
|---|---|
| author | EFSA Panel on Genetically Modified Organisms (EFSA GMO Panel) Hanspeter Naegeli Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Francisco Javier Moreno Ewen Mullins Fabien Nogué Nils Rostoks Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Fernando Álvarez Michele Ardizzone Giacomo De Sanctis Antonio Fernandez Dumont Andrea Gennaro Jose Ángel Gómez Ruiz Anna Lanzoni Franco Maria Neri Konstantinos Paraskevopoulos Tommaso Raffaello |
| author_facet | EFSA Panel on Genetically Modified Organisms (EFSA GMO Panel) Hanspeter Naegeli Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Francisco Javier Moreno Ewen Mullins Fabien Nogué Nils Rostoks Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Fernando Álvarez Michele Ardizzone Giacomo De Sanctis Antonio Fernandez Dumont Andrea Gennaro Jose Ángel Gómez Ruiz Anna Lanzoni Franco Maria Neri Konstantinos Paraskevopoulos Tommaso Raffaello |
| author_sort | EFSA Panel on Genetically Modified Organisms (EFSA GMO Panel) |
| collection | DOAJ |
| description | Abstract Maize MON 87427 × MON 89034 × MIR162 × NK603 (four‐event stack maize) was produced by conventional crossing to combine four single events: MON 87427, MON 89034, MIR162 and NK603. The GMO Panel previously assessed the four single maize events and four of the subcombinations did not identify safety concerns. No new data on the single maize events or the four subcombinations that could lead to modification of the original conclusions on their safety were identified. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single maize events and of the newly expressed proteins in the four‐event stack maize does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that the four‐event stack maize, as described in this application, is as safe as and nutritionally equivalent to its non‐GM comparator and the non‐GM reference varieties tested. In the case of accidental release of viable grains of the four‐event stack maize into the environment, this would not raise environmental safety concerns. The GMO Panel assessed the likelihood of interactions among the single events in the six maize subcombinations not previously assessed and concludes that these are expected to be as safe as and nutritionally equivalent to the single events, the previously assessed subcombinations and the four‐event stack maize. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of the four‐event stack maize. Post‐market monitoring of food/feed is not considered necessary. The GMO Panel concludes that the four‐event stack maize and its subcombinations are as safe as its non‐GM comparator and the tested non‐GM reference varieties with respect to potential effects on human and animal health and the environment. |
| first_indexed | 2024-12-22T08:59:33Z |
| format | Article |
| id | doaj.art-5b75b1ffc1ac4841a9b17fc4ac0558db |
| institution | Directory Open Access Journal |
| issn | 1831-4732 |
| language | English |
| last_indexed | 2024-12-22T08:59:33Z |
| publishDate | 2019-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj.art-5b75b1ffc1ac4841a9b17fc4ac0558db2022-12-21T18:31:46ZengWileyEFSA Journal1831-47322019-07-01177n/an/a10.2903/j.efsa.2019.5734Assessment of genetically modified maize MON 87427 × MON 89034 × MIR162 × NK603 and subcombinations, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2016‐131)EFSA Panel on Genetically Modified Organisms (EFSA GMO Panel)Hanspeter NaegeliJean‐Louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoFrancisco Javier MorenoEwen MullinsFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiFernando ÁlvarezMichele ArdizzoneGiacomo De SanctisAntonio Fernandez DumontAndrea GennaroJose Ángel Gómez RuizAnna LanzoniFranco Maria NeriKonstantinos ParaskevopoulosTommaso RaffaelloAbstract Maize MON 87427 × MON 89034 × MIR162 × NK603 (four‐event stack maize) was produced by conventional crossing to combine four single events: MON 87427, MON 89034, MIR162 and NK603. The GMO Panel previously assessed the four single maize events and four of the subcombinations did not identify safety concerns. No new data on the single maize events or the four subcombinations that could lead to modification of the original conclusions on their safety were identified. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single maize events and of the newly expressed proteins in the four‐event stack maize does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that the four‐event stack maize, as described in this application, is as safe as and nutritionally equivalent to its non‐GM comparator and the non‐GM reference varieties tested. In the case of accidental release of viable grains of the four‐event stack maize into the environment, this would not raise environmental safety concerns. The GMO Panel assessed the likelihood of interactions among the single events in the six maize subcombinations not previously assessed and concludes that these are expected to be as safe as and nutritionally equivalent to the single events, the previously assessed subcombinations and the four‐event stack maize. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of the four‐event stack maize. Post‐market monitoring of food/feed is not considered necessary. The GMO Panel concludes that the four‐event stack maize and its subcombinations are as safe as its non‐GM comparator and the tested non‐GM reference varieties with respect to potential effects on human and animal health and the environment.https://doi.org/10.2903/j.efsa.2019.5734GMOmaize (Zea mays)MON 87427MON 89034MIR162NK603 |
| spellingShingle | EFSA Panel on Genetically Modified Organisms (EFSA GMO Panel) Hanspeter Naegeli Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Francisco Javier Moreno Ewen Mullins Fabien Nogué Nils Rostoks Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Fernando Álvarez Michele Ardizzone Giacomo De Sanctis Antonio Fernandez Dumont Andrea Gennaro Jose Ángel Gómez Ruiz Anna Lanzoni Franco Maria Neri Konstantinos Paraskevopoulos Tommaso Raffaello Assessment of genetically modified maize MON 87427 × MON 89034 × MIR162 × NK603 and subcombinations, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2016‐131) EFSA Journal GMO maize (Zea mays) MON 87427 MON 89034 MIR162 NK603 |
| title | Assessment of genetically modified maize MON 87427 × MON 89034 × MIR162 × NK603 and subcombinations, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2016‐131) |
| title_full | Assessment of genetically modified maize MON 87427 × MON 89034 × MIR162 × NK603 and subcombinations, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2016‐131) |
| title_fullStr | Assessment of genetically modified maize MON 87427 × MON 89034 × MIR162 × NK603 and subcombinations, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2016‐131) |
| title_full_unstemmed | Assessment of genetically modified maize MON 87427 × MON 89034 × MIR162 × NK603 and subcombinations, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2016‐131) |
| title_short | Assessment of genetically modified maize MON 87427 × MON 89034 × MIR162 × NK603 and subcombinations, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2016‐131) |
| title_sort | assessment of genetically modified maize mon 87427 mon 89034 mir162 nk603 and subcombinations for food and feed uses under regulation ec no 1829 2003 application efsa gmo nl 2016 131 |
| topic | GMO maize (Zea mays) MON 87427 MON 89034 MIR162 NK603 |
| url | https://doi.org/10.2903/j.efsa.2019.5734 |
| work_keys_str_mv | AT efsapanelongeneticallymodifiedorganismsefsagmopanel assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT hanspeternaegeli assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT jeanlouisbresson assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT tamasdalmay assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT iancrawforddewhurst assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT michellemepstein assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT lesliegeorgefirbank assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT philippeguerche assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT janhejatko assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT franciscojaviermoreno assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT ewenmullins assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT fabiennogue assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT nilsrostoks assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT josejuansanchezserrano assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT giovannisavoini assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT eveveromann assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT fabioveronesi assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT fernandoalvarez assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT micheleardizzone assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT giacomodesanctis assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT antoniofernandezdumont assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT andreagennaro assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT joseangelgomezruiz assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT annalanzoni assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT francomarianeri assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT konstantinosparaskevopoulos assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 AT tommasoraffaello assessmentofgeneticallymodifiedmaizemon87427mon89034mir162nk603andsubcombinationsforfoodandfeedusesunderregulationecno18292003applicationefsagmonl2016131 |