Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions
Neuroblastoma (NB) is the most common pediatric tumor malignancy that originates from the neural crest and accounts for more than 15% of all the childhood deaths from cancer. The neuroblastoma cancer research has long been focused on the role of MYCN oncogene amplification and the contribution of ot...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/8/2057 |
| _version_ | 1797561301657976832 |
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| author | Shweta Joshi |
| author_facet | Shweta Joshi |
| author_sort | Shweta Joshi |
| collection | DOAJ |
| description | Neuroblastoma (NB) is the most common pediatric tumor malignancy that originates from the neural crest and accounts for more than 15% of all the childhood deaths from cancer. The neuroblastoma cancer research has long been focused on the role of MYCN oncogene amplification and the contribution of other genetic alterations in the progression of this malignancy. However, it is now widely accepted that, not only tumor cells, but the components of tumor microenvironment (TME), including extracellular matrix, stromal cells and immune cells, also contribute to tumor progression in neuroblastoma. The complexity of different components of tumor stroma and their resemblance with surrounding normal tissues pose huge challenges for therapies targeting tumor microenvironment in NB. Hence, the detailed understanding of the composition of the TME of NB is crucial to improve existing and future potential immunotherapeutic approaches against this childhood cancer. In this review article, I will discuss different components of the TME of NB and the recent advances in the strategies, which are used to target the tumor microenvironment in neuroblastoma. |
| first_indexed | 2024-03-10T18:12:57Z |
| format | Article |
| id | doaj.art-5b766c38036c46a0956ce831831e0d87 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T18:12:57Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5b766c38036c46a0956ce831831e0d872023-11-20T07:57:22ZengMDPI AGCancers2072-66942020-07-01128205710.3390/cancers12082057Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future DirectionsShweta Joshi0Department of Pediatrics, Division of Pediatric Hematology-Oncology, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093-0815, USANeuroblastoma (NB) is the most common pediatric tumor malignancy that originates from the neural crest and accounts for more than 15% of all the childhood deaths from cancer. The neuroblastoma cancer research has long been focused on the role of MYCN oncogene amplification and the contribution of other genetic alterations in the progression of this malignancy. However, it is now widely accepted that, not only tumor cells, but the components of tumor microenvironment (TME), including extracellular matrix, stromal cells and immune cells, also contribute to tumor progression in neuroblastoma. The complexity of different components of tumor stroma and their resemblance with surrounding normal tissues pose huge challenges for therapies targeting tumor microenvironment in NB. Hence, the detailed understanding of the composition of the TME of NB is crucial to improve existing and future potential immunotherapeutic approaches against this childhood cancer. In this review article, I will discuss different components of the TME of NB and the recent advances in the strategies, which are used to target the tumor microenvironment in neuroblastoma.https://www.mdpi.com/2072-6694/12/8/2057tumor microenvironmentneuroblastomaimmunosuppressionhypoxiaextracellular matrixmetastasis |
| spellingShingle | Shweta Joshi Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions Cancers tumor microenvironment neuroblastoma immunosuppression hypoxia extracellular matrix metastasis |
| title | Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions |
| title_full | Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions |
| title_fullStr | Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions |
| title_full_unstemmed | Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions |
| title_short | Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions |
| title_sort | targeting the tumor microenvironment in neuroblastoma recent advances and future directions |
| topic | tumor microenvironment neuroblastoma immunosuppression hypoxia extracellular matrix metastasis |
| url | https://www.mdpi.com/2072-6694/12/8/2057 |
| work_keys_str_mv | AT shwetajoshi targetingthetumormicroenvironmentinneuroblastomarecentadvancesandfuturedirections |