Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers
Synthetic mimics of glycoproteins and proteoglycans have wide applications in biomedicine, yet preparation has been challenged by their high grafting and glycosylation densities. Here the authors show one-pot dual-catalysis polymerization of glycan-bearing α-amino acid N-carboxyanhydrides to form gl...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26808-5 |
| _version_ | 1819003304735145984 |
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| author | Zachary S. Clauss Casia L. Wardzala Austin E. Schlirf Nathaniel S. Wright Simranpreet S. Saini Bibiana Onoa Carlos Bustamante Jessica R. Kramer |
| author_facet | Zachary S. Clauss Casia L. Wardzala Austin E. Schlirf Nathaniel S. Wright Simranpreet S. Saini Bibiana Onoa Carlos Bustamante Jessica R. Kramer |
| author_sort | Zachary S. Clauss |
| collection | DOAJ |
| description | Synthetic mimics of glycoproteins and proteoglycans have wide applications in biomedicine, yet preparation has been challenged by their high grafting and glycosylation densities. Here the authors show one-pot dual-catalysis polymerization of glycan-bearing α-amino acid N-carboxyanhydrides to form glycopolypeptide brushes. |
| first_indexed | 2024-12-20T23:18:53Z |
| format | Article |
| id | doaj.art-5b77b5d064be4c76a8a641d34508d0c7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T23:18:53Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5b77b5d064be4c76a8a641d34508d0c72022-12-21T19:23:34ZengNature PortfolioNature Communications2041-17232021-11-0112111110.1038/s41467-021-26808-5Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymersZachary S. Clauss0Casia L. Wardzala1Austin E. Schlirf2Nathaniel S. Wright3Simranpreet S. Saini4Bibiana Onoa5Carlos Bustamante6Jessica R. Kramer7Department of Biomedical Engineering, University of UtahDepartment of Biomedical Engineering, University of UtahDepartment of Biomedical Engineering, University of UtahDepartment of Biomedical Engineering, University of UtahDepartment of Biomedical Engineering, University of UtahHoward Hughes Medical Institute University of California BerkeleyHoward Hughes Medical Institute University of California BerkeleyDepartment of Biomedical Engineering, University of UtahSynthetic mimics of glycoproteins and proteoglycans have wide applications in biomedicine, yet preparation has been challenged by their high grafting and glycosylation densities. Here the authors show one-pot dual-catalysis polymerization of glycan-bearing α-amino acid N-carboxyanhydrides to form glycopolypeptide brushes.https://doi.org/10.1038/s41467-021-26808-5 |
| spellingShingle | Zachary S. Clauss Casia L. Wardzala Austin E. Schlirf Nathaniel S. Wright Simranpreet S. Saini Bibiana Onoa Carlos Bustamante Jessica R. Kramer Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers Nature Communications |
| title | Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers |
| title_full | Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers |
| title_fullStr | Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers |
| title_full_unstemmed | Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers |
| title_short | Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers |
| title_sort | tunable biodegradable grafting from glycopolypeptide bottlebrush polymers |
| url | https://doi.org/10.1038/s41467-021-26808-5 |
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