Lipidomic Predictors of Coronary No-Reflow
The ‘no-reflow’ phenomenon (NRP) after primary percutaneous coronary intervention (PCI) is a serious complication among acute ST-segment elevation myocardial infarction (STEMI) patients. Herein, a comprehensive lipidomics approach was used to quantify over 300 distinct molecular species in circulati...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/1/79 |
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| author | Arun Surendran Umar Ismail Negar Atefi Ashim K. Bagchi Pawan K. Singal Ashish Shah Michel Aliani Amir Ravandi |
| author_facet | Arun Surendran Umar Ismail Negar Atefi Ashim K. Bagchi Pawan K. Singal Ashish Shah Michel Aliani Amir Ravandi |
| author_sort | Arun Surendran |
| collection | DOAJ |
| description | The ‘no-reflow’ phenomenon (NRP) after primary percutaneous coronary intervention (PCI) is a serious complication among acute ST-segment elevation myocardial infarction (STEMI) patients. Herein, a comprehensive lipidomics approach was used to quantify over 300 distinct molecular species in circulating plasma from 126 patients with STEMI before and after primary PCI. Our analysis showed that three lipid classes: phosphatidylcholine (PC), alkylphosphatidylcholine (PC(O)), and sphingomyelin (SM), were significantly elevated (<i>p</i> < 0.05) in no-reflow patients before primary PCI. The levels of individual fatty acids and total fatty acid levels were significantly lower (<i>p</i> < 0.05) in no-reflow subjects after PCI. The grouping of patients based on ECG ST-segment resolution (STR) also demonstrated the same trend, confirming the possible role of these differential lipids in the setting of no-reflow. Sphingomyelin species, SM 41:1 and SM 41:2, was invariably positively correlated with corrected TIMI frame count (CTFC) at pre-PCI and post-PCI. The plasma levels of SM 42:1 exhibited an inverse association (<i>p</i> < 0.05) consistently with tumor necrosis factor-alpha (TNF-α) at pre-PCI and post-PCI. In conclusion, we identified plasma lipid profiles that distinguish individuals at risk of no-reflow and provided novel insights into how dyslipidemia may contribute to NRP after primary PCI. |
| first_indexed | 2024-03-09T11:42:27Z |
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| id | doaj.art-5b77f95c22444e2bbf398eed8b64e5dd |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T11:42:27Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-5b77f95c22444e2bbf398eed8b64e5dd2023-11-30T23:28:42ZengMDPI AGMetabolites2218-19892023-01-011317910.3390/metabo13010079Lipidomic Predictors of Coronary No-ReflowArun Surendran0Umar Ismail1Negar Atefi2Ashim K. Bagchi3Pawan K. Singal4Ashish Shah5Michel Aliani6Amir Ravandi7Cardiovascular Lipidomics Laboratory, St. Boniface Hospital, Albrechtsen Research Centre, Winnipeg, MB R2H 2A6, CanadaSection of Cardiology, Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, CanadaCardiovascular Lipidomics Laboratory, St. Boniface Hospital, Albrechtsen Research Centre, Winnipeg, MB R2H 2A6, CanadaDepartment of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72204, USADepartment of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R2H 2A6, CanadaDepartment of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R2H 2A6, CanadaFaculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, MB R2H 2A6, CanadaCardiovascular Lipidomics Laboratory, St. Boniface Hospital, Albrechtsen Research Centre, Winnipeg, MB R2H 2A6, CanadaThe ‘no-reflow’ phenomenon (NRP) after primary percutaneous coronary intervention (PCI) is a serious complication among acute ST-segment elevation myocardial infarction (STEMI) patients. Herein, a comprehensive lipidomics approach was used to quantify over 300 distinct molecular species in circulating plasma from 126 patients with STEMI before and after primary PCI. Our analysis showed that three lipid classes: phosphatidylcholine (PC), alkylphosphatidylcholine (PC(O)), and sphingomyelin (SM), were significantly elevated (<i>p</i> < 0.05) in no-reflow patients before primary PCI. The levels of individual fatty acids and total fatty acid levels were significantly lower (<i>p</i> < 0.05) in no-reflow subjects after PCI. The grouping of patients based on ECG ST-segment resolution (STR) also demonstrated the same trend, confirming the possible role of these differential lipids in the setting of no-reflow. Sphingomyelin species, SM 41:1 and SM 41:2, was invariably positively correlated with corrected TIMI frame count (CTFC) at pre-PCI and post-PCI. The plasma levels of SM 42:1 exhibited an inverse association (<i>p</i> < 0.05) consistently with tumor necrosis factor-alpha (TNF-α) at pre-PCI and post-PCI. In conclusion, we identified plasma lipid profiles that distinguish individuals at risk of no-reflow and provided novel insights into how dyslipidemia may contribute to NRP after primary PCI.https://www.mdpi.com/2218-1989/13/1/79no-reflowlipidomicssphingomyelinether-lipids |
| spellingShingle | Arun Surendran Umar Ismail Negar Atefi Ashim K. Bagchi Pawan K. Singal Ashish Shah Michel Aliani Amir Ravandi Lipidomic Predictors of Coronary No-Reflow Metabolites no-reflow lipidomics sphingomyelin ether-lipids |
| title | Lipidomic Predictors of Coronary No-Reflow |
| title_full | Lipidomic Predictors of Coronary No-Reflow |
| title_fullStr | Lipidomic Predictors of Coronary No-Reflow |
| title_full_unstemmed | Lipidomic Predictors of Coronary No-Reflow |
| title_short | Lipidomic Predictors of Coronary No-Reflow |
| title_sort | lipidomic predictors of coronary no reflow |
| topic | no-reflow lipidomics sphingomyelin ether-lipids |
| url | https://www.mdpi.com/2218-1989/13/1/79 |
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