Vitamin D and Aging: Central Role of Immunocompetence
The pro-hormone vitamin D<sub>3</sub> is an important modulator of both innate and adaptive immunity since its biologically active metabolite 1α,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>) regulates via the transcription facto...
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MDPI AG
2024-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/3/398 |
| _version_ | 1797318376634187776 |
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| author | Carsten Carlberg Eunike Velleuer |
| author_facet | Carsten Carlberg Eunike Velleuer |
| author_sort | Carsten Carlberg |
| collection | DOAJ |
| description | The pro-hormone vitamin D<sub>3</sub> is an important modulator of both innate and adaptive immunity since its biologically active metabolite 1α,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>) regulates via the transcription factor VDR (vitamin D receptor) the epigenome and transcriptome of human immune cells and controls in this way the expression of hundreds of vitamin D target genes. Since the myeloid linage of hematopoiesis is epigenetically programmed by VDR in concert with the pioneer factors PU.1 (purine-rich box 1) and CEBPα (CCAAT/enhancer binding protein α), monocytes, macrophages, and dendritic cells are the most vitamin D-sensitive immune cell types. The central role of the immune system in various aging-related diseases suggests that immunocompetence describes not only the ability of an individual to resist pathogens and parasites but also to contest non-communicative diseases and the process of aging itself. In this review, we argue that the individual-specific responsiveness to vitamin D relates to a person’s immunocompetence via the epigenetic programming function of VDR and its ligand 1,25(OH)<sub>2</sub>D<sub>3</sub> during hematopoiesis as well as in the periphery. This may provide a mechanism explaining how vitamin D protects against major common diseases and, in parallel, promotes healthy aging. |
| first_indexed | 2024-03-08T03:51:42Z |
| format | Article |
| id | doaj.art-5b781fd55d1d4cbf8cd9643a64b98c1a |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T03:51:42Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-5b781fd55d1d4cbf8cd9643a64b98c1a2024-02-09T15:19:50ZengMDPI AGNutrients2072-66432024-01-0116339810.3390/nu16030398Vitamin D and Aging: Central Role of ImmunocompetenceCarsten Carlberg0Eunike Velleuer1Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, PL-10-748 Olsztyn, PolandDepartment for Cytopathology, Heinrich-Heine-University Düsseldorf, D-40225 Düsseldorf, GermanyThe pro-hormone vitamin D<sub>3</sub> is an important modulator of both innate and adaptive immunity since its biologically active metabolite 1α,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>) regulates via the transcription factor VDR (vitamin D receptor) the epigenome and transcriptome of human immune cells and controls in this way the expression of hundreds of vitamin D target genes. Since the myeloid linage of hematopoiesis is epigenetically programmed by VDR in concert with the pioneer factors PU.1 (purine-rich box 1) and CEBPα (CCAAT/enhancer binding protein α), monocytes, macrophages, and dendritic cells are the most vitamin D-sensitive immune cell types. The central role of the immune system in various aging-related diseases suggests that immunocompetence describes not only the ability of an individual to resist pathogens and parasites but also to contest non-communicative diseases and the process of aging itself. In this review, we argue that the individual-specific responsiveness to vitamin D relates to a person’s immunocompetence via the epigenetic programming function of VDR and its ligand 1,25(OH)<sub>2</sub>D<sub>3</sub> during hematopoiesis as well as in the periphery. This may provide a mechanism explaining how vitamin D protects against major common diseases and, in parallel, promotes healthy aging.https://www.mdpi.com/2072-6643/16/3/398vitamin Daginginnate immunityimmunocompetencehematopoiesisepigenome |
| spellingShingle | Carsten Carlberg Eunike Velleuer Vitamin D and Aging: Central Role of Immunocompetence Nutrients vitamin D aging innate immunity immunocompetence hematopoiesis epigenome |
| title | Vitamin D and Aging: Central Role of Immunocompetence |
| title_full | Vitamin D and Aging: Central Role of Immunocompetence |
| title_fullStr | Vitamin D and Aging: Central Role of Immunocompetence |
| title_full_unstemmed | Vitamin D and Aging: Central Role of Immunocompetence |
| title_short | Vitamin D and Aging: Central Role of Immunocompetence |
| title_sort | vitamin d and aging central role of immunocompetence |
| topic | vitamin D aging innate immunity immunocompetence hematopoiesis epigenome |
| url | https://www.mdpi.com/2072-6643/16/3/398 |
| work_keys_str_mv | AT carstencarlberg vitamindandagingcentralroleofimmunocompetence AT eunikevelleuer vitamindandagingcentralroleofimmunocompetence |