Collie eye anomaly: a review
Collie eye anomaly (CEA) is an inherited congenital visual impairment with heterogeneous signs. The first symptoms are already visible in the early embryo. Among the most affected breeds are Collies and Shetland Sheepdogs but the disease has spread to different breeds depending on the country of ori...
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2015-07-01
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| Series: | Veterinární Medicína |
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| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-201507-0001_collie-eye-anomaly-a-review.php |
| _version_ | 1797897515078516736 |
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| author | A. Palanova |
| author_facet | A. Palanova |
| author_sort | A. Palanova |
| collection | DOAJ |
| description | Collie eye anomaly (CEA) is an inherited congenital visual impairment with heterogeneous signs. The first symptoms are already visible in the early embryo. Among the most affected breeds are Collies and Shetland Sheepdogs but the disease has spread to different breeds depending on the country of origin. Dogs affected with this disease share a 7.8 kb deletion in intron 4 of the NHEJ1 gene. Inheritance of this disease is autosomal recessive with incomplete penetrance. Thanks to a commercially available genetic test breeders can identify genetically affected recessive homozygotes and clinically healthy but genetic carriers of the mutation and thus select healthy parents for the next generation of dogs. However, the exact cause of the disease is not known and it is not known whether the causative mutation influences the occurrence of some other diseases (e.g. immunodeficiencies). |
| first_indexed | 2024-04-10T07:59:36Z |
| format | Article |
| id | doaj.art-5b7909c74f0946feb5f90e99d5cb253e |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-04-10T07:59:36Z |
| publishDate | 2015-07-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-5b7909c74f0946feb5f90e99d5cb253e2023-02-23T03:50:24ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922015-07-0160734535010.17221/8381-VETMEDvet-201507-0001Collie eye anomaly: a reviewA. Palanova0Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech RepublicCollie eye anomaly (CEA) is an inherited congenital visual impairment with heterogeneous signs. The first symptoms are already visible in the early embryo. Among the most affected breeds are Collies and Shetland Sheepdogs but the disease has spread to different breeds depending on the country of origin. Dogs affected with this disease share a 7.8 kb deletion in intron 4 of the NHEJ1 gene. Inheritance of this disease is autosomal recessive with incomplete penetrance. Thanks to a commercially available genetic test breeders can identify genetically affected recessive homozygotes and clinically healthy but genetic carriers of the mutation and thus select healthy parents for the next generation of dogs. However, the exact cause of the disease is not known and it is not known whether the causative mutation influences the occurrence of some other diseases (e.g. immunodeficiencies).https://vetmed.agriculturejournals.cz/artkey/vet-201507-0001_collie-eye-anomaly-a-review.phphereditaryeyediseasedog |
| spellingShingle | A. Palanova Collie eye anomaly: a review Veterinární Medicína hereditary eye disease dog |
| title | Collie eye anomaly: a review |
| title_full | Collie eye anomaly: a review |
| title_fullStr | Collie eye anomaly: a review |
| title_full_unstemmed | Collie eye anomaly: a review |
| title_short | Collie eye anomaly: a review |
| title_sort | collie eye anomaly a review |
| topic | hereditary eye disease dog |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-201507-0001_collie-eye-anomaly-a-review.php |
| work_keys_str_mv | AT apalanova collieeyeanomalyareview |