Induced degeneration and regeneration in aged muscle reduce tubular aggregates but not muscle function

Induced degeneration and regeneration in aged muscle reduce tubular aggregates but not muscle function

IntroductionTubular aggregates (TA) are skeletal muscle structures that arise from the progressive accumulation of sarcoplasmic reticulum proteins. Cytoplasmic aggregates in muscle fibers have already been observed in mice and humans, mainly during aging and muscle disease processes. However, the ef...

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Main Authors: Felipe Tadeu Galante Rocha de Vasconcelos, Antonio Fernando Ribeiro Júnior, Brandow Willy Souza, Isabela de Aquino Zogbi, Laura Machado Lara Carvalho, Letícia Nogueira Feitosa, Lucas Santos Souza, Nathália Gagliardi Saldys, Merari de Fátima Ramires Ferrari, Mariz Vainzof
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Neurology
Subjects:
tubular aggregates
muscle regeneration
aging
muscular dystrophies
neuromuscular disease
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2024.1325222/full

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