Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus
The extent of damage to the nervous, vascular and microcirculatory systems in diabetic patients determine the regulation of physiological events that lead to the formation of chronic wounds, reduction of patient quality of life and increase of the financial value of medical care. Successful physiolo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2016-11-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/8131 |
| _version_ | 1826588107184537600 |
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| author | Ekaterina Viktorovna Artemova Anna Maksimovna Gorbacheva Gagik Radikovich Galstyan Alla Yur'evna Tokmakova Svetlana Anatol'evna Gavrilova Ivan Ivanovich Dedov |
| author_facet | Ekaterina Viktorovna Artemova Anna Maksimovna Gorbacheva Gagik Radikovich Galstyan Alla Yur'evna Tokmakova Svetlana Anatol'evna Gavrilova Ivan Ivanovich Dedov |
| author_sort | Ekaterina Viktorovna Artemova |
| collection | DOAJ |
| description | The extent of damage to the nervous, vascular and microcirculatory systems in diabetic patients determine the regulation of physiological events that lead to the formation of chronic wounds, reduction of patient quality of life and increase of the financial value of medical care. Successful physiological repair is impossible without the successive phases of inflammation, proliferation and wound healing. Keratinocytes are the major cellular barrier components of the epidermis. These cells play an important role in physiological repair, as suggested by recent research, with many cells able to secrete steroid hormones de novo. Damage to the integrity of the skin leads to keratinocyte activation, triggering a cascade of reactions that contribute to changes in epidermal cell phenotype and lead to their proliferation and migration, analogous to changes in cellular adhesion and configuration of the cytoskeleton. An open question remains as to how the keratinocyte cell cycle, which is altered under conditions of hyperglycemia, and neurotransmitter metabolism during different stages of physiological repair are regulated. Understanding these processes will provide a scientific basis for the development of new targets for pharmacotherapies. |
| first_indexed | 2024-03-08T15:20:08Z |
| format | Article |
| id | doaj.art-5b7afcebea3846418fb543caf748dadd |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2025-03-14T16:36:04Z |
| publishDate | 2016-11-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-5b7afcebea3846418fb543caf748dadd2025-02-21T09:29:34ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782016-11-0119536637410.14341/DM81317524Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitusEkaterina Viktorovna Artemova0Anna Maksimovna Gorbacheva1Gagik Radikovich Galstyan2Alla Yur'evna Tokmakova3Svetlana Anatol'evna Gavrilova4Ivan Ivanovich Dedov5Endocrinolgy Research CentreLomonosov Moscow State UniversityEndocrinolgy Research CentreEndocrinolgy Research CentreLomonosov Moscow State UniversityEndocrinolgy Research CentreThe extent of damage to the nervous, vascular and microcirculatory systems in diabetic patients determine the regulation of physiological events that lead to the formation of chronic wounds, reduction of patient quality of life and increase of the financial value of medical care. Successful physiological repair is impossible without the successive phases of inflammation, proliferation and wound healing. Keratinocytes are the major cellular barrier components of the epidermis. These cells play an important role in physiological repair, as suggested by recent research, with many cells able to secrete steroid hormones de novo. Damage to the integrity of the skin leads to keratinocyte activation, triggering a cascade of reactions that contribute to changes in epidermal cell phenotype and lead to their proliferation and migration, analogous to changes in cellular adhesion and configuration of the cytoskeleton. An open question remains as to how the keratinocyte cell cycle, which is altered under conditions of hyperglycemia, and neurotransmitter metabolism during different stages of physiological repair are regulated. Understanding these processes will provide a scientific basis for the development of new targets for pharmacotherapies.https://www.dia-endojournals.ru/jour/article/view/8131diabetes mellituskeratinocyteschronic woundsdiabetic footneuroregulationadrenoreceptorscholinoreceptors |
| spellingShingle | Ekaterina Viktorovna Artemova Anna Maksimovna Gorbacheva Gagik Radikovich Galstyan Alla Yur'evna Tokmakova Svetlana Anatol'evna Gavrilova Ivan Ivanovich Dedov Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus Сахарный диабет diabetes mellitus keratinocytes chronic wounds diabetic foot neuroregulation adrenoreceptors cholinoreceptors |
| title | Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus |
| title_full | Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus |
| title_fullStr | Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus |
| title_full_unstemmed | Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus |
| title_short | Neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus |
| title_sort | neurohumoral mechanisms of keratinocytes regulation in diabetes mellitus |
| topic | diabetes mellitus keratinocytes chronic wounds diabetic foot neuroregulation adrenoreceptors cholinoreceptors |
| url | https://www.dia-endojournals.ru/jour/article/view/8131 |
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