Safety of Cryopreserved Stem Cell Infusion through a Peripherally Inserted Central Venous Catheter
The management of patients undergoing stem cell transplantation requires a multipurpose central venous catheter (CVC) to facilitate drug administration, parenteral nutrition, transfusion of blood products, and collection of blood samples. Peripherally inserted central venous catheters (PICCs) appear...
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MDPI AG
2023-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/4/1338 |
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| author | Sławomir Milczarek Piotr Kulig Alina Zuchmańska Bartłomiej Baumert Bogumiła Osękowska Anna Bielikowicz Ewa Wilk-Milczarek Bogusław Machaliński |
| author_facet | Sławomir Milczarek Piotr Kulig Alina Zuchmańska Bartłomiej Baumert Bogumiła Osękowska Anna Bielikowicz Ewa Wilk-Milczarek Bogusław Machaliński |
| author_sort | Sławomir Milczarek |
| collection | DOAJ |
| description | The management of patients undergoing stem cell transplantation requires a multipurpose central venous catheter (CVC) to facilitate drug administration, parenteral nutrition, transfusion of blood products, and collection of blood samples. Peripherally inserted central venous catheters (PICCs) appear to meet these requirements but are rarely used for stem cell infusion. We aimed to retrospectively assess the safety and feasibility of stem cell infusion through PICC and to evaluate its impact on transplantation kinetics. We retrospectively analyzed the outcomes of peripheral blood stem cell (PBSC) transplantation in patients receiving cryopreserved autologous or allogeneic PBSC by PICCs and compared the results with patients receiving transplants through a conventionally inserted central venous catheter (CICC). Despite statistically significant differences in CD34<sup>+</sup> dose, infusion rate, and total length of administration, the clinical outcomes of transplantation, exemplified by platelet and neutrophil engraftment, along with the length of hospitalization, were not affected by the prolonged infusion time and lower infusion velocity in the PICC group. Our study showed that the clinical outcomes of PBSC transplantation did not differ between the PICC and CICC groups, suggesting that both types of catheters can be implemented in a PBSC transplantation setting. |
| first_indexed | 2024-03-11T09:01:54Z |
| format | Article |
| id | doaj.art-5b7c9a97829d48d09d43b9028da6505f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:01:54Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5b7c9a97829d48d09d43b9028da6505f2023-11-16T19:39:37ZengMDPI AGCancers2072-66942023-02-01154133810.3390/cancers15041338Safety of Cryopreserved Stem Cell Infusion through a Peripherally Inserted Central Venous CatheterSławomir Milczarek0Piotr Kulig1Alina Zuchmańska2Bartłomiej Baumert3Bogumiła Osękowska4Anna Bielikowicz5Ewa Wilk-Milczarek6Bogusław Machaliński7Department of General Pathology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of General and Dental Radiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, PolandThe management of patients undergoing stem cell transplantation requires a multipurpose central venous catheter (CVC) to facilitate drug administration, parenteral nutrition, transfusion of blood products, and collection of blood samples. Peripherally inserted central venous catheters (PICCs) appear to meet these requirements but are rarely used for stem cell infusion. We aimed to retrospectively assess the safety and feasibility of stem cell infusion through PICC and to evaluate its impact on transplantation kinetics. We retrospectively analyzed the outcomes of peripheral blood stem cell (PBSC) transplantation in patients receiving cryopreserved autologous or allogeneic PBSC by PICCs and compared the results with patients receiving transplants through a conventionally inserted central venous catheter (CICC). Despite statistically significant differences in CD34<sup>+</sup> dose, infusion rate, and total length of administration, the clinical outcomes of transplantation, exemplified by platelet and neutrophil engraftment, along with the length of hospitalization, were not affected by the prolonged infusion time and lower infusion velocity in the PICC group. Our study showed that the clinical outcomes of PBSC transplantation did not differ between the PICC and CICC groups, suggesting that both types of catheters can be implemented in a PBSC transplantation setting.https://www.mdpi.com/2072-6694/15/4/1338PICCCICCauto-HSCTallo-HSCThigh-dose chemotherapyhematological malignancy |
| spellingShingle | Sławomir Milczarek Piotr Kulig Alina Zuchmańska Bartłomiej Baumert Bogumiła Osękowska Anna Bielikowicz Ewa Wilk-Milczarek Bogusław Machaliński Safety of Cryopreserved Stem Cell Infusion through a Peripherally Inserted Central Venous Catheter Cancers PICC CICC auto-HSCT allo-HSCT high-dose chemotherapy hematological malignancy |
| title | Safety of Cryopreserved Stem Cell Infusion through a Peripherally Inserted Central Venous Catheter |
| title_full | Safety of Cryopreserved Stem Cell Infusion through a Peripherally Inserted Central Venous Catheter |
| title_fullStr | Safety of Cryopreserved Stem Cell Infusion through a Peripherally Inserted Central Venous Catheter |
| title_full_unstemmed | Safety of Cryopreserved Stem Cell Infusion through a Peripherally Inserted Central Venous Catheter |
| title_short | Safety of Cryopreserved Stem Cell Infusion through a Peripherally Inserted Central Venous Catheter |
| title_sort | safety of cryopreserved stem cell infusion through a peripherally inserted central venous catheter |
| topic | PICC CICC auto-HSCT allo-HSCT high-dose chemotherapy hematological malignancy |
| url | https://www.mdpi.com/2072-6694/15/4/1338 |
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