A Child with Prostaglandin I2-associated Thyrotoxicosis: Case Report
Prostaglandin I2 (PGI2) causes hyperthyroidism, a critical complication in patients with pulmonary arterial hypertension (PAH). However, it remains unknown whether PGI2 may have unfavorable effects on thyroid function in children with congenital portosystemic venous shunt syndrome (CPSVS). We presen...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayincilik
2019-06-01
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| Series: | JCRPE |
| Subjects: | |
| Online Access: |
http://www.jcrpe.org/archives/archive-detail/article-preview/a-child-with-prostaglandin-sub2-sub-associated-thy/19867
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| _version_ | 1797924184254316544 |
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| author | Yuri Sonoda Kenichiro Yamamura Kanako Ishii Kazuhiro Ohkubo Kenji Ihara Yasunari Sakai Shouichi Ohga |
| author_facet | Yuri Sonoda Kenichiro Yamamura Kanako Ishii Kazuhiro Ohkubo Kenji Ihara Yasunari Sakai Shouichi Ohga |
| author_sort | Yuri Sonoda |
| collection | DOAJ |
| description | Prostaglandin I2 (PGI2) causes hyperthyroidism, a critical complication in patients with pulmonary arterial hypertension (PAH). However, it remains unknown whether PGI2 may have unfavorable effects on thyroid function in children with congenital portosystemic venous shunt syndrome (CPSVS). We present a boy with CPSVS who developed PAH at seven years of age. During ongoing PGI2 therapy, he experienced thyrotoxicosis at 17 years of age. The literature review showed that the reported 12 patients with PAH (median 11 years of age) developed hyperthyroidism during between one and 11 years of PGI2 treatment. Only one patient survived the acute PAH crisis due to hyperthyroidism. These data provide evidence that prophylactic intervention for hyperthyroidism is indicated for children with CPSVS during PGI2 treatment. |
| first_indexed | 2024-04-10T14:57:34Z |
| format | Article |
| id | doaj.art-5b7d28b931d34e24ada4e1e12caf2cef |
| institution | Directory Open Access Journal |
| issn | 1308-5727 1308-5735 |
| language | English |
| last_indexed | 2024-04-10T14:57:34Z |
| publishDate | 2019-06-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | JCRPE |
| spelling | doaj.art-5b7d28b931d34e24ada4e1e12caf2cef2023-02-15T16:07:15ZengGalenos YayincilikJCRPE1308-57271308-57352019-06-0111220721010.4274/jcrpe.galenos.2018.2018.016913049054A Child with Prostaglandin I2-associated Thyrotoxicosis: Case ReportYuri Sonoda0Kenichiro Yamamura1Kanako Ishii2Kazuhiro Ohkubo3Kenji Ihara4Yasunari Sakai5Shouichi Ohga6 Kyushu University Graduate School of Medical Sciences, Department of Pediatrics, Fukuoka, Japan Kyushu University Graduate School of Medical Sciences, Department of Pediatrics, Fukuoka, Japan Kyushu University Graduate School of Medical Sciences, Department of Pediatrics, Fukuoka, Japan Kyushu University Graduate School of Medical Sciences, Department of Pediatrics, Fukuoka, Japan Kyushu University Graduate School of Medical Sciences, Department of Pediatrics, Fukuoka, Japan Kyushu University Graduate School of Medical Sciences, Department of Pediatrics, Fukuoka, Japan Kyushu University Graduate School of Medical Sciences, Department of Pediatrics, Fukuoka, Japan Prostaglandin I2 (PGI2) causes hyperthyroidism, a critical complication in patients with pulmonary arterial hypertension (PAH). However, it remains unknown whether PGI2 may have unfavorable effects on thyroid function in children with congenital portosystemic venous shunt syndrome (CPSVS). We present a boy with CPSVS who developed PAH at seven years of age. During ongoing PGI2 therapy, he experienced thyrotoxicosis at 17 years of age. The literature review showed that the reported 12 patients with PAH (median 11 years of age) developed hyperthyroidism during between one and 11 years of PGI2 treatment. Only one patient survived the acute PAH crisis due to hyperthyroidism. These data provide evidence that prophylactic intervention for hyperthyroidism is indicated for children with CPSVS during PGI2 treatment. http://www.jcrpe.org/archives/archive-detail/article-preview/a-child-with-prostaglandin-sub2-sub-associated-thy/19867 Prostaglandin I2pulmonary arterial hypertensioncongenital portosystemic venous shunt syndromehyperthyroidism |
| spellingShingle | Yuri Sonoda Kenichiro Yamamura Kanako Ishii Kazuhiro Ohkubo Kenji Ihara Yasunari Sakai Shouichi Ohga A Child with Prostaglandin I2-associated Thyrotoxicosis: Case Report JCRPE Prostaglandin I2 pulmonary arterial hypertension congenital portosystemic venous shunt syndrome hyperthyroidism |
| title | A Child with Prostaglandin I2-associated Thyrotoxicosis: Case Report |
| title_full | A Child with Prostaglandin I2-associated Thyrotoxicosis: Case Report |
| title_fullStr | A Child with Prostaglandin I2-associated Thyrotoxicosis: Case Report |
| title_full_unstemmed | A Child with Prostaglandin I2-associated Thyrotoxicosis: Case Report |
| title_short | A Child with Prostaglandin I2-associated Thyrotoxicosis: Case Report |
| title_sort | child with prostaglandin i2 associated thyrotoxicosis case report |
| topic | Prostaglandin I2 pulmonary arterial hypertension congenital portosystemic venous shunt syndrome hyperthyroidism |
| url |
http://www.jcrpe.org/archives/archive-detail/article-preview/a-child-with-prostaglandin-sub2-sub-associated-thy/19867
|
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