βγ G-proteins, but not regulators of G-protein signaling 4, modulate opioid-induced respiratory rate depression
Opioid medications are the mainstay of pain management but present substantial side-effects such as respiratory depression which can be lethal with overdose. Most opioid drugs, such as fentanyl, act on opioid receptors such as the G-protein-coupled µ-opioid receptors (MOR). G-protein-coupled recepto...
Main Authors: | Jamil Danaf, Carolina da Silveira Scarpellini, Gaspard Montandon |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-04-01
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Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1043581/full |
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