Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response
Oncolytic virus (OV) treatment may offer a new treatment option for the aggressive brain tumor glioblastoma. Clinical trials testing oncolytic viruses in this patient group have shown promising results, with patients achieving impressive long-term clinical responses. However, the number of responder...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/4/614 |
| _version_ | 1797415400263122944 |
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| author | Eftychia Stavrakaki Clemens M. F. Dirven Martine L. M. Lamfers |
| author_facet | Eftychia Stavrakaki Clemens M. F. Dirven Martine L. M. Lamfers |
| author_sort | Eftychia Stavrakaki |
| collection | DOAJ |
| description | Oncolytic virus (OV) treatment may offer a new treatment option for the aggressive brain tumor glioblastoma. Clinical trials testing oncolytic viruses in this patient group have shown promising results, with patients achieving impressive long-term clinical responses. However, the number of responders to each OV remains low. This is thought to arise from the large heterogeneity of these tumors, both in terms of molecular make-up and their immune-suppressive microenvironment, leading to variability in responses. An approach that may improve response rates is the personalized utilization of oncolytic viruses against Glioblastoma (GBM), based on specific tumor- or patient-related characteristics. In this review, we discuss potential biomarkers for response to different OVs as well as emerging ex vivo assays that in the future may enable selection of optimal OV for a specific patient and design of stratified clinical OV trials for GBM. |
| first_indexed | 2024-03-09T05:47:04Z |
| format | Article |
| id | doaj.art-5b832371ae6a42f9bd724014ff1cb853 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T05:47:04Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5b832371ae6a42f9bd724014ff1cb8532023-12-03T12:20:04ZengMDPI AGCancers2072-66942021-02-0113461410.3390/cancers13040614Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for ResponseEftychia Stavrakaki0Clemens M. F. Dirven1Martine L. M. Lamfers2Department of Neurosurgery, Brain Tumor Center, Erasmus University Medical Center, 3015 CN Rotterdam, The NetherlandsDepartment of Neurosurgery, Brain Tumor Center, Erasmus University Medical Center, 3015 CN Rotterdam, The NetherlandsDepartment of Neurosurgery, Brain Tumor Center, Erasmus University Medical Center, 3015 CN Rotterdam, The NetherlandsOncolytic virus (OV) treatment may offer a new treatment option for the aggressive brain tumor glioblastoma. Clinical trials testing oncolytic viruses in this patient group have shown promising results, with patients achieving impressive long-term clinical responses. However, the number of responders to each OV remains low. This is thought to arise from the large heterogeneity of these tumors, both in terms of molecular make-up and their immune-suppressive microenvironment, leading to variability in responses. An approach that may improve response rates is the personalized utilization of oncolytic viruses against Glioblastoma (GBM), based on specific tumor- or patient-related characteristics. In this review, we discuss potential biomarkers for response to different OVs as well as emerging ex vivo assays that in the future may enable selection of optimal OV for a specific patient and design of stratified clinical OV trials for GBM.https://www.mdpi.com/2072-6694/13/4/614oncolytic virusesglioblastomaclinical trialsbiomarkerspersonalized oncolyticvirotherapy |
| spellingShingle | Eftychia Stavrakaki Clemens M. F. Dirven Martine L. M. Lamfers Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response Cancers oncolytic viruses glioblastoma clinical trials biomarkers personalized oncolyticvirotherapy |
| title | Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response |
| title_full | Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response |
| title_fullStr | Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response |
| title_full_unstemmed | Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response |
| title_short | Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response |
| title_sort | personalizing oncolytic virotherapy for glioblastoma in search of biomarkers for response |
| topic | oncolytic viruses glioblastoma clinical trials biomarkers personalized oncolyticvirotherapy |
| url | https://www.mdpi.com/2072-6694/13/4/614 |
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