Epigenetics: New Insights into Mammary Gland Biology
The mammary gland undergoes important anatomical and physiological changes from embryogenesis through puberty, pregnancy, lactation and involution. These steps are under the control of a complex network of molecular factors, in which epigenetic mechanisms play a role that is increasingly well descri...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/2/231 |
| _version_ | 1797414513780195328 |
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| author | Elitsa Ivanova Sandrine Le Guillou Cathy Hue-Beauvais Fabienne Le Provost |
| author_facet | Elitsa Ivanova Sandrine Le Guillou Cathy Hue-Beauvais Fabienne Le Provost |
| author_sort | Elitsa Ivanova |
| collection | DOAJ |
| description | The mammary gland undergoes important anatomical and physiological changes from embryogenesis through puberty, pregnancy, lactation and involution. These steps are under the control of a complex network of molecular factors, in which epigenetic mechanisms play a role that is increasingly well described. Recently, studies investigating epigenetic modifications and their impacts on gene expression in the mammary gland have been performed at different physiological stages and in different mammary cell types. This has led to the establishment of a role for epigenetic marks in milk component biosynthesis. This review aims to summarize the available knowledge regarding the involvement of the four main molecular mechanisms in epigenetics: DNA methylation, histone modifications, polycomb protein activity and non-coding RNA functions. |
| first_indexed | 2024-03-09T05:34:21Z |
| format | Article |
| id | doaj.art-5b841395e1a242b3b0e36231dd0de5b8 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T05:34:21Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-5b841395e1a242b3b0e36231dd0de5b82023-12-03T12:30:18ZengMDPI AGGenes2073-44252021-02-0112223110.3390/genes12020231Epigenetics: New Insights into Mammary Gland BiologyElitsa Ivanova0Sandrine Le Guillou1Cathy Hue-Beauvais2Fabienne Le Provost3GABI, INRAE, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, FranceGABI, INRAE, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, FranceGABI, INRAE, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, FranceGABI, INRAE, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, FranceThe mammary gland undergoes important anatomical and physiological changes from embryogenesis through puberty, pregnancy, lactation and involution. These steps are under the control of a complex network of molecular factors, in which epigenetic mechanisms play a role that is increasingly well described. Recently, studies investigating epigenetic modifications and their impacts on gene expression in the mammary gland have been performed at different physiological stages and in different mammary cell types. This has led to the establishment of a role for epigenetic marks in milk component biosynthesis. This review aims to summarize the available knowledge regarding the involvement of the four main molecular mechanisms in epigenetics: DNA methylation, histone modifications, polycomb protein activity and non-coding RNA functions.https://www.mdpi.com/2073-4425/12/2/231mammary glandepigenetic regulationslactationDNA methylationnon-coding RNA |
| spellingShingle | Elitsa Ivanova Sandrine Le Guillou Cathy Hue-Beauvais Fabienne Le Provost Epigenetics: New Insights into Mammary Gland Biology Genes mammary gland epigenetic regulations lactation DNA methylation non-coding RNA |
| title | Epigenetics: New Insights into Mammary Gland Biology |
| title_full | Epigenetics: New Insights into Mammary Gland Biology |
| title_fullStr | Epigenetics: New Insights into Mammary Gland Biology |
| title_full_unstemmed | Epigenetics: New Insights into Mammary Gland Biology |
| title_short | Epigenetics: New Insights into Mammary Gland Biology |
| title_sort | epigenetics new insights into mammary gland biology |
| topic | mammary gland epigenetic regulations lactation DNA methylation non-coding RNA |
| url | https://www.mdpi.com/2073-4425/12/2/231 |
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