Value of biochemical markers in predicting outcome of COVID-19 infection in University Hospital, Alexandria, Egypt
This paper aims to examine the value of different biochemical markers in predicting the outcome of COVID-19 infection. A total of 140 patients with confirmed COVID-19 infection by polymerase chain reaction (PCR), different biochemical markers were tested, their relation to the outcome of the diseas...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2023-06-01
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| Series: | Healthcare in Low-resource Settings |
| Subjects: | |
| Online Access: | https://www.pagepressjournals.org/index.php/hls/article/view/11323 |
| _version_ | 1797224670707056640 |
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| author | Neveen Rashad Mostafa Abeer Ahmed Mohamed Ali Rehab Moustafa Ezzat Mostafa Kamel Bakry Roy Rillera Marzo |
| author_facet | Neveen Rashad Mostafa Abeer Ahmed Mohamed Ali Rehab Moustafa Ezzat Mostafa Kamel Bakry Roy Rillera Marzo |
| author_sort | Neveen Rashad Mostafa |
| collection | DOAJ |
| description |
This paper aims to examine the value of different biochemical markers in predicting the outcome of COVID-19 infection. A total of 140 patients with confirmed COVID-19 infection by polymerase chain reaction (PCR), different biochemical markers were tested, their relation to the outcome of the disease was monitored, and the most reliable tests were determined. The study found a significant correlation between all evaluated biochemical markers and severity of the disease, including C-reactive protein (CRP), D-dimer, alanine aminotransferase (ALT), Aspartate aminotransferase (AST), prothrombin time (PT), activated partial thromboplastin time (aPTT). In addition, ferritin, lactate dehydrogenase (LDH), procalcitonin (PCT) and Pro- Brain natriuretic peptide (proBNP) demonstrated highly sensitivity and specificity as well as significant prognostic performance. These markers were also independently significant in predicting mortality. Early assessment of biochemical markers in patients with COVID-19 can help clinicians in tailoring treatment and providing more intensive care to those with greater mortality risk. In particular, the assessment of ferritin, LDH, procalcitonin and proBNP can independently predict mortality.
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| first_indexed | 2024-04-24T13:56:49Z |
| format | Article |
| id | doaj.art-5b847c565eea41609cc95fd6b22ee5b5 |
| institution | Directory Open Access Journal |
| issn | 2281-7824 |
| language | English |
| last_indexed | 2024-04-24T13:56:49Z |
| publishDate | 2023-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Healthcare in Low-resource Settings |
| spelling | doaj.art-5b847c565eea41609cc95fd6b22ee5b52024-04-03T17:28:46ZengPAGEPress PublicationsHealthcare in Low-resource Settings2281-78242023-06-0111s210.4081/hls.2023.11323Value of biochemical markers in predicting outcome of COVID-19 infection in University Hospital, Alexandria, EgyptNeveen Rashad Mostafa0Abeer Ahmed Mohamed Ali1Rehab Moustafa Ezzat2Mostafa Kamel Bakry3Roy Rillera Marzo4Department of Internal Medicine, Medical Research Institute, Alexandria UniversityDepartment of Chemical pathology, Medical Research Institute, Alexandria UniversityDepartment of Pulmonology, Alexandria Student University Hospital, Alexandria UniversityDepartment of ENT, Alexandria student university hospital, Alexandria UniversityDepartment of Community Medicine, International Medical School, Management and Science University, Shah Alam; Global Public Health, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Kuala Lumpur This paper aims to examine the value of different biochemical markers in predicting the outcome of COVID-19 infection. A total of 140 patients with confirmed COVID-19 infection by polymerase chain reaction (PCR), different biochemical markers were tested, their relation to the outcome of the disease was monitored, and the most reliable tests were determined. The study found a significant correlation between all evaluated biochemical markers and severity of the disease, including C-reactive protein (CRP), D-dimer, alanine aminotransferase (ALT), Aspartate aminotransferase (AST), prothrombin time (PT), activated partial thromboplastin time (aPTT). In addition, ferritin, lactate dehydrogenase (LDH), procalcitonin (PCT) and Pro- Brain natriuretic peptide (proBNP) demonstrated highly sensitivity and specificity as well as significant prognostic performance. These markers were also independently significant in predicting mortality. Early assessment of biochemical markers in patients with COVID-19 can help clinicians in tailoring treatment and providing more intensive care to those with greater mortality risk. In particular, the assessment of ferritin, LDH, procalcitonin and proBNP can independently predict mortality. https://www.pagepressjournals.org/index.php/hls/article/view/11323Biochemical markersCOVID-19cytokinesmortality |
| spellingShingle | Neveen Rashad Mostafa Abeer Ahmed Mohamed Ali Rehab Moustafa Ezzat Mostafa Kamel Bakry Roy Rillera Marzo Value of biochemical markers in predicting outcome of COVID-19 infection in University Hospital, Alexandria, Egypt Healthcare in Low-resource Settings Biochemical markers COVID-19 cytokines mortality |
| title | Value of biochemical markers in predicting outcome of COVID-19 infection in University Hospital, Alexandria, Egypt |
| title_full | Value of biochemical markers in predicting outcome of COVID-19 infection in University Hospital, Alexandria, Egypt |
| title_fullStr | Value of biochemical markers in predicting outcome of COVID-19 infection in University Hospital, Alexandria, Egypt |
| title_full_unstemmed | Value of biochemical markers in predicting outcome of COVID-19 infection in University Hospital, Alexandria, Egypt |
| title_short | Value of biochemical markers in predicting outcome of COVID-19 infection in University Hospital, Alexandria, Egypt |
| title_sort | value of biochemical markers in predicting outcome of covid 19 infection in university hospital alexandria egypt |
| topic | Biochemical markers COVID-19 cytokines mortality |
| url | https://www.pagepressjournals.org/index.php/hls/article/view/11323 |
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