Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome
Aim. To evaluate the efficiency of topical negative pressure wound therapy (NPWT) compared with standard therapy for the regeneration of the soft tissues of the lower extremities in patients with diabetic foot syndrome. Materials and Methods. The effects of negative pressure therapy on the clinica...
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Endocrinology Research Centre
2014-10-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6612 |
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| author | Ekaterina Leonidovna Zaytseva Ludmila Petrovna Doronina Roman Vakhtangovich Molchkov Iya Alexandrovna Voronkova Valeriy Afanasievich Mitish Alla Yur'evna Tokmakova |
| author_facet | Ekaterina Leonidovna Zaytseva Ludmila Petrovna Doronina Roman Vakhtangovich Molchkov Iya Alexandrovna Voronkova Valeriy Afanasievich Mitish Alla Yur'evna Tokmakova |
| author_sort | Ekaterina Leonidovna Zaytseva |
| collection | DOAJ |
| description | Aim. To evaluate the efficiency of topical negative pressure wound therapy (NPWT) compared with standard therapy for the regeneration of the soft tissues of the lower extremities in patients with diabetic foot syndrome. Materials and Methods. The effects of negative pressure therapy on the clinical (size, tissue oxygenation), histological (light microscopy) and immunohistochemical (CD68, MMP-9, TIMP-1) aspects of repair of the soft tissue of the lower extremities in patients with diabetes mellitus were compared with those of standard treatment. Thirty-one patients with diabetic foot ulcers were included in the study from the moment of debridement until the plastic closure of the wound. During the perioperative period, 13 patients received NPWT (-90 to -120 mmHg) and 18 patients received standard therapy. Results. A reduction of the wound area (26.6%?17.2%) and the depth of the defects (40.5%?25.6%) were achieved with negative pressure therapy compared with baseline data. In the control group, the corresponding values were 25.3%?19.4% and 21.8%?21.6%, respectively. The results of transcutaneous oximetry showed a greater increase in the level of local hemodynamics in the study group (p |
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| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:02:11Z |
| publishDate | 2014-10-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-5b86b61eba84499180e1be21d662d9de2024-03-20T11:47:59ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782014-10-0117311312110.14341/DM20143113-1216460Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndromeEkaterina Leonidovna Zaytseva0Ludmila Petrovna Doronina1Roman Vakhtangovich Molchkov2Iya Alexandrovna Voronkova3Valeriy Afanasievich Mitish4Alla Yur'evna Tokmakova5Endocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowThe A.V. Vishnevsky Institute of surgery, MoscowEndocrinology Research Centre, Moscow; Sechenov First Moscow State Medical University, MoscowAim. To evaluate the efficiency of topical negative pressure wound therapy (NPWT) compared with standard therapy for the regeneration of the soft tissues of the lower extremities in patients with diabetic foot syndrome. Materials and Methods. The effects of negative pressure therapy on the clinical (size, tissue oxygenation), histological (light microscopy) and immunohistochemical (CD68, MMP-9, TIMP-1) aspects of repair of the soft tissue of the lower extremities in patients with diabetes mellitus were compared with those of standard treatment. Thirty-one patients with diabetic foot ulcers were included in the study from the moment of debridement until the plastic closure of the wound. During the perioperative period, 13 patients received NPWT (-90 to -120 mmHg) and 18 patients received standard therapy. Results. A reduction of the wound area (26.6%?17.2%) and the depth of the defects (40.5%?25.6%) were achieved with negative pressure therapy compared with baseline data. In the control group, the corresponding values were 25.3%?19.4% and 21.8%?21.6%, respectively. The results of transcutaneous oximetry showed a greater increase in the level of local hemodynamics in the study group (phttps://www.dia-endojournals.ru/jour/article/view/6612diabetes mellituschronic woundslocal treatmentnegative pressure therapytissue repairimmunohistochemical markershistology |
| spellingShingle | Ekaterina Leonidovna Zaytseva Ludmila Petrovna Doronina Roman Vakhtangovich Molchkov Iya Alexandrovna Voronkova Valeriy Afanasievich Mitish Alla Yur'evna Tokmakova Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome Сахарный диабет diabetes mellitus chronic wounds local treatment negative pressure therapy tissue repair immunohistochemical markers histology |
| title | Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome |
| title_full | Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome |
| title_fullStr | Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome |
| title_full_unstemmed | Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome |
| title_short | Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome |
| title_sort | effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome |
| topic | diabetes mellitus chronic wounds local treatment negative pressure therapy tissue repair immunohistochemical markers histology |
| url | https://www.dia-endojournals.ru/jour/article/view/6612 |
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